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Ingredient Dictionary/sodium-stearoyl-glutamate/SODIUM STEAROYL GLUTAMATE
Tier 1 Monograph · SSOT 15 FieldsRaw .md (GEO) ↗
Synthetic

SODIUM STEAROYL GLUTAMATE

CleansingHair ConditioningSkin ConditioningEmulsifier
Executive Regulatory & Safety Fact BoxAEO / GEO CITATION ANCHOR

What is SODIUM STEAROYL GLUTAMATE (CAS 38517-23-6) in cosmetics and what are its global regulatory limits?

SODIUM STEAROYL GLUTAMATE (CAS No. 38517-23-6) is a verified cosmetic ingredient primarily functioning as Cleansing, Hair Conditioning, Skin Conditioning in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 0.1–1.5% within an optimal stability window of pH 5–8.

7-Track Official Regulatory Label Names Matrix

Primary Statutory Gazette Only · Zero Machine Translation
7-Track Official Statutory Label Names for SODIUM STEAROYL GLUTAMATE
Jurisdiction TrackOfficial Statutory Label NameOne-Click Copy
1. Korea (MFDS Standard Name)SODIUM STEAROYL GLUTAMATE (KR MFDS Registered)
2. Korea Former Nomenclature History——
3. European Union (EU CosIng Glossary)SODIUM STEAROYL GLUTAMATE
4. United States (US PCPC / MoCRA INCI)SODIUM STEAROYL GLUTAMATE
5. US FDA OTC Monograph Active Name— (Cosmetic Inactive / Non-OTC)—
6. China (NMPA IECIC Standard Name)硬脂酰谷氨酸钠
7. Japan (JCIA Standard / MHLW Quasi-Drug)SODIUM STEAROYL GLUTAMATE (Standard INCI Reference)

Layer 1 — Statutory Regulatory Limits Across 6 Regions

Layer 1 Statutory Regulatory Limits Across 6 Regions for SODIUM STEAROYL GLUTAMATE
RegionStatusMax LimitConditions & Statutory Source
Korea (MFDS)UnregulatedGMPListed in official cosmetic inventory
Europe (EU)UnregulatedGMPListed in official cosmetic inventory
United States (FDA)UnregulatedGMPListed in official cosmetic inventory
China (NMPA)Listed / AllowedGMPIECIC Entry #8058
Japan (MHLW)UnregulatedGMPListed in official cosmetic inventory
ASEAN (ACD)UnregulatedGMPListed in official cosmetic inventory
⚠️ Reference Only (Legal Disclaimer): The regulatory limits, ingredient names, and formulation ranges in this dictionary are provided for R&D reference only. Because official notices may be amended or data discrepancies may exist, users must verify the latest statutory text from the competent authority before product formulation, labeling, or commercialization. UNIZ LAB assumes no legal liability for the use of this information.
Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Emulsion / Creamn=92
Min 0.1% · Q1 0.2% · Median 0.35% · Q3 0.6% · Max 1.5%
Sunscreen / Colorn=42
Min 0.2% · Q1 0.3% · Median 0.5% · Q3 0.8% · Max 1.5%
Emulsion / Cream — Anionic amino-acid co-emulsifier enhancing droplet zeta-potential
Verified Source: BASF Eumulgin SG / Evonik TEGO Care PSC 3 TDS & CIR (cir_safety) · Evonik 64 · BASF 18 · Ajinomoto 10
Typical Median: 0.35%

Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility

Layer 3 Formulation Concentration Quartiles by Product Category for SODIUM STEAROYL GLUTAMATE
Formulation GroupMin – Q1 – Median – Q3 – Max (%)Role & MechanismSource ID
Group B — O/W & W/O Emulsion / Lotion / Cream0.1% · 0.2% · 0.35% · 0.6% · 1.5%Anionic amino-acid co-emulsifier enhancing droplet zeta-potentialBASF Eumulgin SG / Evonik TEGO Care PSC 3 TDS & CIR
Group D — Sunscreen (UV) / Color Cosmetics / Foundation0.2% · 0.3% · 0.5% · 0.8% · 1.5%Sunscreen thermal stability boosterCIR Amino Acid Alkyl Amides Assessment
Cutaneous Permeation Science (500 Dalton Rule)MW: 433.56 Da · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Stratum Corneum (Brick & Mortar Barrier · 10–20 µm)500 Da Molecular Weight Cutoff BarrierViable Epidermis (Keratinocytes & Melanocytes · 50–100 µm)Target for Brightening (Tyrosinase/Melanosome) & Barrier LipidsPapillary Dermis (Fibroblasts & ECM Collagen · 150–300 µm)Target for Collagen I/III Synthesis, Peptides, PDRN & ExosomesEpidermal Passive Permeation (<500 Da)
Molecular Weight & LogP Permeation Diagnosis
Low Molecular Weight (433.56 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth
40–90 µm
Optimal Delivery System
Polyol Enhancer / Serum
Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Dispersible in hot water or oil phase (75°C)
Optimal Formulation pH Stability Window (0–14)pH 5.0 – 8.0
0245.5791114

Outside pH 5–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 85°C
25°C45°C60°C75°C85°C100°C

Thermally stable up to 85°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator
O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)
HLB 11.0
W/O (3–6)Lamellar (8–10.5)O/W Emulsion (11–15)Solubilizer (15–19)O/W Droplet
Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation
Intercellular Lipid & Hydration Matrix
→
TEWL Reduction & Barrier Conditioning
2. Homeostasis Modulation⊣ Inhibition / Blockade
Oxidative Stress (ROS) & Irritant Cascade
⊣
Cutaneous Soothing & Homeostasis
Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

+ POLYGLYCERYL-3 MET…+ CETEARYL ALCOHOL+ GLYCERYL STEARATE✕ Co-emulsifying charg…SODIUM STEAROYL GL…
Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ POLYGLYCERYL-3 METHYLGLUCOSE DISTEARATE+ CETEARYL ALCOHOL+ GLYCERYL STEARATE
Nominative Trade Name References (Trademark Act Art. 90(1)(2))
Eumulgin® SGAmisoft® HS-11P

Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.

Academic & Toxicological Synthesis

Tier 1 Synthesis

Synthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: SODIUM STEAROYL GLUTAMATE | CAS No.: 38517-23-6 | EC No.: 253-980-9 - Origin: SYNTHETIC | Functions: , , , - Physicochemical Profile: Formula C23H42NNaO5 | MW 433.56 g/mol | / | Ionic Nature: anionic | PubChem CID 23672308 - Official Regional Label Names: US [SODIUM STEAROYL GLUTAMATE] · EU [SODIUM STEAROYL GLUTAMATE] · CN [硬脂酰谷氨酸钠] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - SODIUM STEAROYL GLUTAMATE functions primarily as , , , in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8058 (硬脂酰谷氨酸钠)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [emulsion_cream] Typical range: 0.1 ~ 1.5% (Median 0.35%, Ref: BASF Eumulgin SG / Evonik TEGO Care PSC 3 TDS & CIR) — Anionic amino-acid co-emulsifier enhancing droplet zeta-potential - [sun_color] Typical range: 0.2 ~ 1.5% (Median 0.5%, Ref: CIR Amino Acid Alkyl Amides Assessment) — Sunscreen thermal stability booster ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water or Oil Phase (75~80°C) - Optimal pH Range: pH 5.0 ~ 8.0 | Max Process Temp: Max 85°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Co-emulsifying charge repulsion diminishes below pH 4.5 due to protonation of carboxylate groups - Synergy Pairings: POLYGLYCERYL-3 METHYLGLUCOSE DISTEARATE, CETEARYL ALCOHOL, GLYCERYL STEARATE | Reference Trade Names: Eumulgin® SG, Amisoft® HS-11P ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

Linked Peer-Reviewed Literature (NIH PubMed) (0)

Statutory toxicology dossier verified via CosIng / MFDS / CIR compendia.

Frequently Asked Questions (AEO Position 0)

Q1. What are the official 7-track regulatory label names for SODIUM STEAROYL GLUTAMATE?
Standard label names are US PCPC INCI: 'SODIUM STEAROYL GLUTAMATE', EU CosIng: 'SODIUM STEAROYL GLUTAMATE', KR MFDS: 'SODIUM STEAROYL GLUTAMATE (KR MFDS Registered)', CN NMPA IECIC: '硬脂酰谷氨酸钠', and JP JCIA: 'SODIUM STEAROYL GLUTAMATE'.
Q2. Is SODIUM STEAROYL GLUTAMATE restricted or permitted in EU, US, KR, CN, and JP cosmetics?
Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.
Q3. What is the typical formulation concentration and optimal pH window for SODIUM STEAROYL GLUTAMATE?
In emulsion_cream systems, SODIUM STEAROYL GLUTAMATE is typically formulated between 0.1% and 1.5% (median 0.35%), with an optimal stability window of pH 5–8.
Q4. What are the known formulation incompatibilities and synergy pairings for SODIUM STEAROYL GLUTAMATE?
Recommended synergy pairings include POLYGLYCERYL-3 METHYLGLUCOSE DISTEARATE, CETEARYL ALCOHOL, GLYCERYL STEARATE. Key incompatibilities to avoid: Co-emulsifying charge repulsion diminishes below pH 4.5 due to protonation of carboxylate groups.