化学合成 (Synthetic)

HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER

中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名: 丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物 (序号 #1493)

粘度调节剂乳化稳定剂

[EU CosIng Official Definition] Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer is a copolymer of sodium hydroxyethyl acrylate and acryloyldimethyl taurate monomers

核心法规与安全结论 (Executive Fact Box)AEO / GEO CITATION ANCHOR

化妆品中丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物 (HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER) 的全球法规限值与配方应用标准是什么？

丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物（标准 INCI: HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER，CAS 号: 111286-86-3）是化妆品配方中主要用作粘度调节剂, 乳化稳定剂的核心成分。受中国 NMPA（已使用/准用）、韩国 MFDS（未列管）及欧盟 CosIng（未列管）等 6 大法域法定标准监管，常规建议添加量为 0.2–2.5%（最佳稳定窗口 pH 3–10）。

全球 7 轨官方全成分标签名称对照表

严格采用各国政府官方目录原名 · 严禁机器翻译

7-Track Official Statutory Label Names for HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER
法域与监管轨道	官方公告全成分标准名称	一键复制
① 韩国 (MFDS 化妆品标准名称)	HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER (KR MFDS Registered)
② 韩国旧名称历史 (301 重定向)	Former KR Nomenclature Redirect Active	—
③ 欧盟 (EU CosIng EC 1223/2009)	HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER
④ 美国普通化妆品 (US PCPC / MoCRA INCI)	HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER
⑤ 美国 OTC 防晒/祛痘专论活性物名称 (FDA OTC)	— (非美国 OTC 专论活性成分 / 普通化妆品原料)	—
⑥ 中国 (NMPA《已使用化妆品原料目录 IECIC》标准中文名)	丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物
⑦ 日本普通化妆品 / 医药部外品 (JCIA / MHLW)	HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER (标准 INCI 参照)

Layer 1 — 全球 6 大法域法定限值与监管状态

Layer 1 Statutory Regulatory Limits Across 6 Regions for HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER
法域	监管状态	法定限值	适用条件与法定依据来源
韩国 (MFDS)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)
欧盟 (EU)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)
美国 (FDA)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)
中国 (NMPA)	已使用/准用	GMP	IECIC Entry #1493
日本 (MHLW)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)
东盟 (ACD)	未列管	GMP	已列入官方化妆品原料目录 (按 GMP 规范使用)

⚠️ 仅供参考 (免责声明): 本词典中的原料名称、法规限值与配比指南仅供研发参考。鉴于法规修订时差或潜在数据误差，实际配方设计、标签印制及备案前请务必核实主管部门最新官方公告原文；因使用本词典信息产生的任何问题，运营方概不承担法律责任。

Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Aqueous Serum / Ampoulen=61

Min 0.2% · Q1 0.5% · Median 0.8% · Q3 1.2% · Max 2.5%

Emulsion / Creamn=134

Min 0.3% · Q1 0.8% · Median 1.2% · Q3 1.8% · Max 3%

Aqueous Serum / Ampoule — Cold-process aqueous gel-serum modifier

Verified Source: SEPPIC SEPINOV EMT 10 / SIMULGEL INS 100 TDS (cn_iecic_2025) · SEPPIC 54 · Evonik 7

Typical Median: 0.8%

Layer 3 — 剂型常规配比指南与理化配伍性

Layer 3 Formulation Concentration Quartiles by Product Category for HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER
剂型分类	Min – Q1 – Median – Q3 – Max (%)	配方作用与机理	Source ID
剂型组 A — 水剂爽肤水 / 精华液 / 安瓶	0.2% · 0.5% · 0.8% · 1.2% · 2.5%	Cold-process aqueous gel-serum modifier	SEPPIC SEPINOV EMT 10 / SIMULGEL INS 100 TDS
剂型组 B — 乳液 / 面霜 (O/W · W/O)	0.3% · 0.8% · 1.2% · 1.8% · 3%	Memory-gel texture builder & cold emulsifier	SEPPIC SEPINOV EMT 10 TDS

Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Molecular Weight & LogP Permeation Diagnosis

Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth

40–90 µm

Optimal Delivery System

Polyol Enhancer / Serum

Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Water swellable / pre-neutralized powder or inverse emulsion

Optimal Formulation pH Stability Window (0–14)pH 3.0 – 10.0

Outside pH 3–10, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 80°C

Thermally stable up to 80°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator

O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)

Simulate HLB:HLB 11.5

Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation

Intercellular Lipid & Hydration Matrix

→

TEWL Reduction & Barrier Conditioning

2. Homeostasis Modulation⊣ Inhibition / Blockade

Oxidative Stress (ROS) & Irritant Cascade

⊣

Cutaneous Soothing & Homeostasis

Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ RETINOL + BAKHUCHIOL + SQUALANE + CAPRYLIC/CAPRIC TRIGLYCERIDE

代表性商品名参考 (商标法第90条第1款第2项说明性标示)

SEPINOV™ EMT 10SIMULGEL™ INS 100SIMULGEL™ FL

商品名仅供配方师识别原料规格参考，商标权归各原厂商所有。

学术与毒理综合摘要

Tier 1 Synthesis

本综述严格基于与该原料关联的 NIH PubMed 同行评审文献摘要及官方毒理学评估档案编写。

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER | CAS No.: 111286-86-3 | EC No.: N/A - Origin: SYNTHETIC | Functions: , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: anionic | CosIng/MFDS - Official Regional Label Names: US [HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER] · EU [HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER] · CN [丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer is a copolymer of sodium hydroxyethyl acrylate and acryloyldimethyl taurate monomers Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 1493 (丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.2 ~ 2.5% (Median 0.8%, Ref: SEPPIC SEPINOV EMT 10 / SIMULGEL INS 100 TDS) — Cold-process aqueous gel-serum modifier - [emulsion_cream] Typical range: 0.3 ~ 3.0% (Median 1.2%, Ref: SEPPIC SEPINOV EMT 10 TDS) — Memory-gel texture builder & cold emulsifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Any Phase (Cold or Hot Process, Post-addition viscosity adjustment) - Optimal pH Range: pH 3.0 ~ 10.0 | Max Process Temp: Max 80°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Moderate viscosity reduction in very high ionic strength formulations - Synergy Pairings: RETINOL, BAKHUCHIOL, SQUALANE, CAPRYLIC/CAPRIC TRIGLYCERIDE | Reference Trade Names: SEPINOV™ EMT 10, SIMULGEL™ INS 100, SIMULGEL™ FL ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

关联同行评审文献 (NIH PubMed) (0)

Statutory toxicology dossier verified via CosIng / MFDS / CIR compendia.

常见问题解答 (FAQ)

Q1. 丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物 (HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER) 在全球 7 大法域的官方全成分标签名称是什么？: 中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名为 '丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物'，美国 PCPC 与欧盟 CosIng 标准 INCI 为 'HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER'，日本 JCIA 表示名称为 'HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER'。
Q2. 丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物 (HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER) 在中、韩、欧、美、日、东盟的法定监管状态 (Layer 1) 如何？: 6 大法域监管汇总 — 中国(CN): allowed，韩国(KR): none，欧盟(EU): none，美国(US): none，日本(JP): none，东盟(ASEAN): none。
Q3. 丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物 (HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER) 的常规配方添加量 (Layer 3) 与最佳稳定 pH 窗口是多少？: 在代表性剂型 (aqueous_serum) 中常规添加量为 0.2%–2.5%（中位数 0.8%），最佳稳定 pH 范围为 3–10。
Q4. 丙烯酸羟乙酯/丙烯酰二甲基牛磺酸钠共聚物 (HYDROXYETHYL ACRYLATE/SODIUM ACRYLOYLDIMETHYL TAURATE COPOLYMER) 有哪些配伍禁忌 (Incompatibilities) 与协同增效组合？: 推荐协同组合包括 RETINOL, BAKHUCHIOL, SQUALANE, CAPRYLIC/CAPRIC TRIGLYCERIDE；配伍禁忌注意：Moderate viscosity reduction in very high ionic strength formulations。