Synthetic
PROPYLENE CARBONATE
SolventViscosity Controlling
Executive Regulatory & Safety Fact BoxAEO / GEO CITATION ANCHOR
What is PROPYLENE CARBONATE (CAS 108-32-7) in cosmetics and what are its global regulatory limits?
PROPYLENE CARBONATE (CAS No. 108-32-7) is a verified cosmetic ingredient primarily functioning as Solvent, Viscosity Controlling in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 2–10% within an optimal stability window of pH 4–8.
7-Track Official Regulatory Label Names Matrix
Primary Statutory Gazette Only · Zero Machine Translation| Jurisdiction Track | Official Statutory Label Name | One-Click Copy |
|---|---|---|
| 1. Korea (MFDS Standard Name) | PROPYLENE CARBONATE (KR MFDS Registered) | |
| 2. Korea Former Nomenclature History | — | — |
| 3. European Union (EU CosIng Glossary) | PROPYLENE CARBONATE | |
| 4. United States (US PCPC / MoCRA INCI) | PROPYLENE CARBONATE | |
| 5. US FDA OTC Monograph Active Name | — (Cosmetic Inactive / Non-OTC) | — |
| 6. China (NMPA IECIC Standard Name) | 碳酸丙二醇酯 | |
| 7. Japan (JCIA Standard / MHLW Quasi-Drug) | PROPYLENE CARBONATE (Standard INCI Reference) |
Layer 1 — Statutory Regulatory Limits Across 6 Regions
| Region | Status | Max Limit | Conditions & Statutory Source |
|---|---|---|---|
| Korea (MFDS) | Unregulated | GMP | Listed in official cosmetic inventory |
| Europe (EU) | Unregulated | GMP | Listed in official cosmetic inventory |
| United States (FDA) | Unregulated | GMP | Listed in official cosmetic inventory |
| China (NMPA) | Listed / Allowed | GMP | IECIC Entry #6575 |
| Japan (MHLW) | Unregulated | GMP | Listed in official cosmetic inventory |
| ASEAN (ACD) | Unregulated | GMP | Listed in official cosmetic inventory |
⚠️ Reference Only (Legal Disclaimer): The regulatory limits, ingredient names, and formulation ranges in this dictionary are provided for R&D reference only. Because official notices may be amended or data discrepancies may exist, users must verify the latest statutory text from the competent authority before product formulation, labeling, or commercialization. UNIZ LAB assumes no legal liability for the use of this information.
Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)
Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit
Anhydrous Balm / Oiln=5
Min 2% · Q1 2% · Median 3% · Q3 3% · Max 10%
Aqueous Serum / Ampoulen=13
Min 0.01% · Q1 2% · Median 3% · Q3 8% · Max 15%
Sunscreen / Colorn=14
Min 1.5% · Q1 3% · Median 5% · Q3 9.75% · Max 14%
Anhydrous Balm / Oil — Anhydrous balm, oil & stick structural emollient
Verified Source: Global Starter Formulation Library Statistical Distribution (n=5, ELEMENTIS 5) (cir_safety) · ELEMENTIS 5
Typical Median: 3%
Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility
| Formulation Group | Min – Q1 – Median – Q3 – Max (%) | Role & Mechanism | Source ID |
|---|---|---|---|
| Group E — Anhydrous Oil / Stick Balm / Lip Care | 2% · 2% · 3% · 3% · 10% | Anhydrous balm, oil & stick structural emollient | Global Starter Formulation Library Statistical Distribution (n=5, ELEMENTIS 5) |
| Group A — Aqueous Toner / Serum / Ampoule | 0.01% · 2% · 3% · 8% · 15% | Aqueous serum, toner & hydrogel matrix formulation component | Global Starter Formulation Library Statistical Distribution (n=13, ELEMENTIS 12 · GRANT 1) |
| Group D — Sunscreen (UV) / Color Cosmetics / Foundation | 1.5% · 3% · 5% · 9.75% · 14% | Sun care & color cosmetics dispersion / sensory modifier | Global Starter Formulation Library Statistical Distribution (n=14, ELEMENTIS 11 · EVONIK 3) |
Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A
Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery
Molecular Weight & LogP Permeation Diagnosis
Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible
Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.
Estimated Target Depth
40–90 µm
Optimal Delivery System
Polyol Enhancer / Serum
Colloid Interface, pH Spectrum & Thermal Stability
Water or glycol phase soluble/dispersiblepH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior
Optimal Formulation pH Stability Window (0–14)pH 4.0 – 8.0
Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.
Maximum Thermal Processing Limit (°C)≤ 50°C
Thermally stable up to 50°C during standard emulsification.
HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator
O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)
HLB 11.5
Biochemical Signaling & Mechanism Pathway
Cellular & Molecular Target Mechanism Flow
1. Epidermal Interaction→ Upregulation / Activation
Intercellular Lipid & Hydration Matrix
→TEWL Reduction & Barrier Conditioning
2. Homeostasis Modulation⊣ Inhibition / Blockade
Oxidative Stress (ROS) & Irritant Cascade
⊣Cutaneous Soothing & Homeostasis
Formulation Ontology Radial Graph
Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)
Interactive Node Guide
Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.
Nominative Trade Name References (Trademark Act Art. 90(1)(2))
PROPYLENE CARBONATE
Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.
Academic & Toxicological Synthesis
Tier 2 SynthesisSynthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.
PROPYLENE CARBONATE (CAS No. 108-32-7) is a verified cosmetic ingredient primarily functioning as Solvent, Viscosity Controlling in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 2–10% within an optimal stability window of pH 4–8.
Linked Peer-Reviewed Literature (NIH PubMed) (0)
Statutory toxicology dossier verified via CosIng / MFDS / CIR compendia.
Frequently Asked Questions (AEO Position 0)
- Q1. What are the official 7-track regulatory label names for PROPYLENE CARBONATE?
- Standard label names are US PCPC INCI: 'PROPYLENE CARBONATE', EU CosIng: 'PROPYLENE CARBONATE', KR MFDS: 'PROPYLENE CARBONATE (KR MFDS Registered)', CN NMPA IECIC: '碳酸丙二醇酯', and JP JCIA: 'PROPYLENE CARBONATE'.
- Q2. Is PROPYLENE CARBONATE restricted or permitted in EU, US, KR, CN, and JP cosmetics?
- Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.
- Q3. What is the typical formulation concentration and optimal pH window for PROPYLENE CARBONATE?
- In anhydrous_balm systems, PROPYLENE CARBONATE is typically formulated between 2% and 10% (median 3%), with an optimal stability window of pH 4–8.
- Q4. What are the known formulation incompatibilities and synergy pairings for PROPYLENE CARBONATE?
- Recommended synergy pairings include GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL. Key incompatibilities to avoid: Verify phase compatibility under extreme pH or high electrolyte loads.