POLYGLYCERYL-3 DIISOSTEARATE
What is POLYGLYCERYL-3 DIISOSTEARATE (CAS 66082-42-6) in cosmetics and what are its global regulatory limits?
POLYGLYCERYL-3 DIISOSTEARATE (CAS No. 66082-42-6) is a verified cosmetic ingredient primarily functioning as Emulsifier in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 0.5–3% within an optimal stability window of pH 4–8.
7-Track Official Regulatory Label Names Matrix
Primary Statutory Gazette Only · Zero Machine Translation| Jurisdiction Track | Official Statutory Label Name | One-Click Copy |
|---|---|---|
| 1. Korea (MFDS Standard Name) | POLYGLYCERYL-3 DIISOSTEARATE (KR MFDS Registered) | |
| 2. Korea Former Nomenclature History | Former KR Nomenclature Redirect Active | — |
| 3. European Union (EU CosIng Glossary) | POLYGLYCERYL-3 DIISOSTEARATE | |
| 4. United States (US PCPC / MoCRA INCI) | POLYGLYCERYL-3 DIISOSTEARATE | |
| 5. US FDA OTC Monograph Active Name | — (Cosmetic Inactive / Non-OTC) | — |
| 6. China (NMPA IECIC Standard Name) | 聚甘油-3 二异硬脂酸酯 | |
| 7. Japan (JCIA Standard / MHLW Quasi-Drug) | POLYGLYCERYL-3 DIISOSTEARATE (Standard INCI Reference) |
Layer 1 — Statutory Regulatory Limits Across 6 Regions
| Region | Status | Max Limit | Conditions & Statutory Source |
|---|---|---|---|
| Korea (MFDS) | Unregulated | GMP | Listed in official cosmetic inventory |
| Europe (EU) | Unregulated | GMP | Listed in official cosmetic inventory |
| United States (FDA) | Unregulated | GMP | Listed in official cosmetic inventory |
| China (NMPA) | Listed / Allowed | GMP | IECIC Entry #3825 |
| Japan (MHLW) | Unregulated | GMP | Listed in official cosmetic inventory |
| ASEAN (ACD) | Unregulated | GMP | Listed in official cosmetic inventory |
Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit
Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility
| Formulation Group | Min – Q1 – Median – Q3 – Max (%) | Role & Mechanism | Source ID |
|---|---|---|---|
| Group D — Sunscreen (UV) / Color Cosmetics / Foundation | 0.5% · 0.5% · 1% · 2% · 3% | Sun care & color cosmetics dispersion / sensory modifier | Global Starter Formulation Library Statistical Distribution (n=5, GRANT 4 · ELEMENTIS 1) |
Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery
Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.
pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior
Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.
Thermally stable up to 50°C during standard emulsification.
Cellular & Molecular Target Mechanism Flow
Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)
Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.
Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.
Academic & Toxicological Synthesis
Tier 1 SynthesisSynthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.
Linked Peer-Reviewed Literature (NIH PubMed) (1)
Protective effects of avocado peel and seed extracts against UVB-damaged fibroblasts for the development of an anti-photoaging nanoemulgel. [PMID: 40745200 · 2025]
This study investigates the anti-photoaging potential of ethanolic extracts from avocado peel and seed and their application in a nanoemulgel formulation. Both extracts demonstrated high phenolic content and strong antioxidant activity, with DPPH IC 50 values of 57.05 ± 1.65 µg/ml (peel) and 52.44 ± 0.32 µg/ml (seed). In UVB-irradiated human dermal fibroblasts (BJ cells), the extracts (12.5-50 µg/ml) significantly reduced intracellular ROS, decreased MMP-1 and pro-inflammatory cytokines (TNF-α, IL-1β, IL-6), and restored collagen levels. A nanoemulgel was developed using the phase inversion composition (PIC) method, with avocado oil, isononyl isononanoate, Tween 60, and polyglyceryl-3 diisostearate, which resulted in nanoemulsions (NEs) with an average droplet size of 84.45 ± 5.45 nm and a zeta potential of -69.94 ± 5.66 mV. Incorporation of 0.5% Aqupec HV-505E and avocado extracts produced stable, light green gel. The resulting avocado extract-loaded nanoemulgel (ANE) demonstrated antioxidant activity, cytocompatibility with BJ cells, and stability in terms of color, pH, and viscosity. These findings reveal the anti-aging potential of avocado peel and seed extracts in preserving effectiveness within nanoemulgel for skin applications.
Frequently Asked Questions (AEO Position 0)
- Q1. What are the official 7-track regulatory label names for POLYGLYCERYL-3 DIISOSTEARATE?
- Standard label names are US PCPC INCI: 'POLYGLYCERYL-3 DIISOSTEARATE', EU CosIng: 'POLYGLYCERYL-3 DIISOSTEARATE', KR MFDS: 'POLYGLYCERYL-3 DIISOSTEARATE (KR MFDS Registered)', CN NMPA IECIC: '聚甘油-3 二异硬脂酸酯', and JP JCIA: 'POLYGLYCERYL-3 DIISOSTEARATE'.
- Q2. Is POLYGLYCERYL-3 DIISOSTEARATE restricted or permitted in EU, US, KR, CN, and JP cosmetics?
- Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.
- Q3. What is the typical formulation concentration and optimal pH window for POLYGLYCERYL-3 DIISOSTEARATE?
- In sun_color systems, POLYGLYCERYL-3 DIISOSTEARATE is typically formulated between 0.5% and 3% (median 1%), with an optimal stability window of pH 4–8.
- Q4. What are the known formulation incompatibilities and synergy pairings for POLYGLYCERYL-3 DIISOSTEARATE?
- Recommended synergy pairings include GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL. Key incompatibilities to avoid: Verify phase compatibility under extreme pH or high electrolyte loads.