METHYL METHACRYLATE CROSSPOLYMER
What is METHYL METHACRYLATE CROSSPOLYMER (CAS 25777-71-3) in cosmetics and what are its global regulatory limits?
METHYL METHACRYLATE CROSSPOLYMER (CAS No. 25777-71-3) is a verified cosmetic ingredient primarily functioning as Film Forming in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 0.5–10% within an optimal stability window of pH 4–8.
7-Track Official Regulatory Label Names Matrix
Primary Statutory Gazette Only · Zero Machine Translation| Jurisdiction Track | Official Statutory Label Name | One-Click Copy |
|---|---|---|
| 1. Korea (MFDS Standard Name) | METHYL METHACRYLATE CROSSPOLYMER (KR MFDS Registered) | |
| 2. Korea Former Nomenclature History | Former KR Nomenclature Redirect Active | — |
| 3. European Union (EU CosIng Glossary) | METHYL METHACRYLATE CROSSPOLYMER | |
| 4. United States (US PCPC / MoCRA INCI) | METHYL METHACRYLATE CROSSPOLYMER | |
| 5. US FDA OTC Monograph Active Name | — (Cosmetic Inactive / Non-OTC) | — |
| 6. China (NMPA IECIC Standard Name) | 甲基丙烯酸甲酯交联聚合物 | |
| 7. Japan (JCIA Standard / MHLW Quasi-Drug) | METHYL METHACRYLATE CROSSPOLYMER (Standard INCI Reference) |
Layer 1 — Statutory Regulatory Limits Across 6 Regions
| Region | Status | Max Limit | Conditions & Statutory Source |
|---|---|---|---|
| Korea (MFDS) | Unregulated | GMP | Listed in official cosmetic inventory |
| Europe (EU) | Unregulated | GMP | Listed in official cosmetic inventory |
| United States (FDA) | Unregulated | GMP | Listed in official cosmetic inventory |
| China (NMPA) | Listed / Allowed | GMP | IECIC Entry #3295 |
| Japan (MHLW) | Unregulated | GMP | Listed in official cosmetic inventory |
| ASEAN (ACD) | Unregulated | GMP | Listed in official cosmetic inventory |
Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit
Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility
| Formulation Group | Min – Q1 – Median – Q3 – Max (%) | Role & Mechanism | Source ID |
|---|---|---|---|
| Group B — O/W & W/O Emulsion / Lotion / Cream | 0.5% · 1% · 3% · 8% · 10% | Emulsion cream & lotion structural / conditioning agent | Global Starter Formulation Library Statistical Distribution (n=8, SEPPIC 8) |
Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery
Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.
pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior
Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.
Thermally stable up to 50°C during standard emulsification.
Cellular & Molecular Target Mechanism Flow
Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)
Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.
Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.
Academic & Toxicological Synthesis
Tier 1 SynthesisSynthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.
Linked Peer-Reviewed Literature (NIH PubMed) (2)
Final report of the Cosmetic Ingredient Review Expert Panel safety assessment of polymethyl methacrylate (PMMA), methyl methacrylate crosspolymer, and methyl methacrylate/glycol dimethacrylate crosspolymer. [PMID: 21772027 · 2011]
Polymethyl methacrylate (PMMA) and related cosmetic ingredients methyl methacrylate crosspolymer and methyl methacrylate/glycol dimethacrylate crosspolymer are polymers that function as film formers and viscosity-increasing agents in cosmetics. The Food and Drug Administration (FDA) determination of safety of PMMA use in several medical devices, which included human and animal safety data, was used as the basis of safety of PMMA and related polymers in cosmetics by the Cosmetic Ingredient Review (CIR) Expert Panel.  The PMMA used in cosmetics is substantially the same as in medical devices.  The Panel concluded that these ingredients are safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment.
Synergistic/antagonistic antimicrobial effects of cosmetic ingredients in combination with 1,2-hexanediol. [PMID: 39805611 · 2024]
With the rise of the clean beauty trend in the cosmetics and personal care industry, consumers' interest in cosmetic ingredients, especially preservatives, continues to grow. Paraben, previously the most used preservative in cosmetics, has been excluded from many products owing to its potential risks. Therefore, a movement to lower the content of various preservatives is ongoing. One approach to achieve a suitable level of preservation is to use multifunctional ingredients as preservative boosters. In this study, we aimed to confirm the synergistic antimicrobial interactions between various cosmetic ingredients and 1,2-hexanediol, a preservative introduced as a substitute for paraben, using the checkerboard assay. We also measured the antagonistic effect by measuring the fold changes in the minimum inhibitory concentration of 1,2-hexanediol. Niacinamide, a form of vitamin B3, showed synergistic antifungal activity with 1,2-hexanediol, which lowered the content of 1,2-hexanediol in the oil-solubilized toner formulation. Among the substances, 50000 ppm of methyl methacrylate crosspolymer elevated the minimum inhibitory concentration of 1,2-hexanediol against bacteria and fungi by 2‒8 times. Through this study, we suggest applying the synergistic effects of various cosmetic ingredients in the formulation as a method to effectively reduce the content of preservatives.
Frequently Asked Questions (AEO Position 0)
- Q1. What are the official 7-track regulatory label names for METHYL METHACRYLATE CROSSPOLYMER?
- Standard label names are US PCPC INCI: 'METHYL METHACRYLATE CROSSPOLYMER', EU CosIng: 'METHYL METHACRYLATE CROSSPOLYMER', KR MFDS: 'METHYL METHACRYLATE CROSSPOLYMER (KR MFDS Registered)', CN NMPA IECIC: '甲基丙烯酸甲酯交联聚合物', and JP JCIA: 'METHYL METHACRYLATE CROSSPOLYMER'.
- Q2. Is METHYL METHACRYLATE CROSSPOLYMER restricted or permitted in EU, US, KR, CN, and JP cosmetics?
- Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.
- Q3. What is the typical formulation concentration and optimal pH window for METHYL METHACRYLATE CROSSPOLYMER?
- In emulsion_cream systems, METHYL METHACRYLATE CROSSPOLYMER is typically formulated between 0.5% and 10% (median 3%), with an optimal stability window of pH 4–8.
- Q4. What are the known formulation incompatibilities and synergy pairings for METHYL METHACRYLATE CROSSPOLYMER?
- Recommended synergy pairings include GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL. Key incompatibilities to avoid: Verify phase compatibility under extreme pH or high electrolyte loads.