What are the official 7-track regulatory label names for LAURETH-4?

Standard label names are US PCPC INCI: 'LAURETH-4', EU CosIng: 'LAURETH-4', KR MFDS: 'LAURETH-4 (KR MFDS Registered)', CN NMPA IECIC: '月桂醇聚醚-4', and JP JCIA: 'LAURETH-4'.

Is LAURETH-4 restricted or permitted in EU, US, KR, CN, and JP cosmetics?

Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.

What is the typical formulation concentration and optimal pH window for LAURETH-4?

In cleanser_rinse systems, LAURETH-4 is typically formulated between 2% and 5% (median 3%), with an optimal stability window of pH 4–8.

What are the known formulation incompatibilities and synergy pairings for LAURETH-4?

Recommended synergy pairings include GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL. Key incompatibilities to avoid: Verify phase compatibility under extreme pH or high electrolyte loads.

Synthetic

LAURETH-4

AntistaticFragranceEmulsifierCleansing

[EU CosIng Official Definition] 3,6,9,12-tetraoxatetracosan-1-ol; Dodecan-1-ol, ethoxylated; Alcohols, C12-14, ethoxylated

Executive Regulatory & Safety Fact BoxAEO / GEO CITATION ANCHOR

What is LAURETH-4 (CAS 5274-68-0) in cosmetics and what are its global regulatory limits?

LAURETH-4 (CAS No. 5274-68-0) is a verified cosmetic ingredient primarily functioning as Antistatic, Fragrance, Emulsifier in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 2–5% within an optimal stability window of pH 4–8.

7-Track Official Regulatory Label Names Matrix

Primary Statutory Gazette Only · Zero Machine Translation

7-Track Official Statutory Label Names for LAURETH-4
Jurisdiction Track	Official Statutory Label Name	One-Click Copy
1. Korea (MFDS Standard Name)	LAURETH-4 (KR MFDS Registered)
2. Korea Former Nomenclature History	—	—
3. European Union (EU CosIng Glossary)	LAURETH-4
4. United States (US PCPC / MoCRA INCI)	LAURETH-4
5. US FDA OTC Monograph Active Name	— (Cosmetic Inactive / Non-OTC)	—
6. China (NMPA IECIC Standard Name)	月桂醇聚醚-4
7. Japan (JCIA Standard / MHLW Quasi-Drug)	LAURETH-4 (Standard INCI Reference)

Layer 1 — Statutory Regulatory Limits Across 6 Regions

Layer 1 Statutory Regulatory Limits Across 6 Regions for LAURETH-4
Region	Status	Max Limit	Conditions & Statutory Source
Korea (MFDS)	Unregulated	GMP	Listed in official cosmetic inventory
Europe (EU)	Unregulated	GMP	Listed in official cosmetic inventory
United States (FDA)	Unregulated	GMP	Listed in official cosmetic inventory
China (NMPA)	Listed / Allowed	GMP	IECIC Entry #8305
Japan (MHLW)	Unregulated	GMP	Listed in official cosmetic inventory
ASEAN (ACD)	Unregulated	GMP	Listed in official cosmetic inventory

⚠️ Reference Only (Legal Disclaimer): The regulatory limits, ingredient names, and formulation ranges in this dictionary are provided for R&D reference only. Because official notices may be amended or data discrepancies may exist, users must verify the latest statutory text from the competent authority before product formulation, labeling, or commercialization. UNIZ LAB assumes no legal liability for the use of this information.

Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Rinse-off Cleansern=6

Min 2% · Q1 2% · Median 3% · Q3 4% · Max 5%

Emulsion / Creamn=6

Min 1% · Q1 1.875% · Median 3% · Q3 3% · Max 4%

Rinse-off Cleanser — Rinse-off cleanser & surfactant system modifier

Verified Source: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 4 · ELEMENTIS 2) (cir_safety) · EVONIK 4 · ELEMENTIS 2

Typical Median: 3%

Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility

Layer 3 Formulation Concentration Quartiles by Product Category for LAURETH-4
Formulation Group	Min – Q1 – Median – Q3 – Max (%)	Role & Mechanism	Source ID
Group C — Rinse-Off Cleanser / Shampoo / Body Wash	2% · 2% · 3% · 4% · 5%	Rinse-off cleanser & surfactant system modifier	Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 4 · ELEMENTIS 2)
Group B — O/W & W/O Emulsion / Lotion / Cream	1% · 1.875% · 3% · 3% · 4%	Emulsion cream & lotion structural / conditioning agent	Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 5 · GRANT 1)

Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Molecular Weight & LogP Permeation Diagnosis

Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth

40–90 µm

Optimal Delivery System

Polyol Enhancer / Serum

Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Water or glycol phase soluble/dispersible

Optimal Formulation pH Stability Window (0–14)pH 4.0 – 8.0

Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 50°C

Thermally stable up to 50°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator

O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)

Simulate HLB:HLB 11.5

Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation

Intercellular Lipid & Hydration Matrix

→

TEWL Reduction & Barrier Conditioning

2. Homeostasis Modulation⊣ Inhibition / Blockade

Oxidative Stress (ROS) & Irritant Cascade

⊣

Cutaneous Soothing & Homeostasis

Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ GLYCERIN + CAPRYLIC/CAPRIC TRIGLYCERIDE + TOCOPHEROL

Nominative Trade Name References (Trademark Act Art. 90(1)(2))

LAURETH-4

Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.

Academic & Toxicological Synthesis

Tier 1 Synthesis

Synthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: LAURETH-4 | CAS No.: 5274-68-0 | EC No.: 226-097-1 - Origin: SYNTHETIC | Functions: , , , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [LAURETH-4] · EU [LAURETH-4] · CN [月桂醇聚醚-4] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - 3,6,9,12-tetraoxatetracosan-1-ol; Dodecan-1-ol, ethoxylated; Alcohols, C12-14, ethoxylated Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8305 (月桂醇聚醚-4)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [cleanser_rinse] Typical range: 2.0 ~ 5.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 4 · ELEMENTIS 2)) — Rinse-off cleanser & surfactant system modifier - [emulsion_cream] Typical range: 1.0 ~ 4.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 5 · GRANT 1)) — Emulsion cream & lotion structural / conditioning agent ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: LAURETH-4 ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 36981689 (2023, Int J Environ Res Public Health): Potential Carcinogens in Makeup Cosmetics.

Linked Peer-Reviewed Literature (NIH PubMed) (1)

Potential Carcinogens in Makeup Cosmetics. [PMID: 36981689 · 2023]

Balwierz R, Biernat P, Jasińska-Balwierz A, Siodłak D, Kusakiewicz-Dawid A, Kurek-Górecka A, Olczyk P, Ochędzan-Siodłak W · Int J Environ Res Public Health (2023)

Facial makeup cosmetics are commonly used products that are applied to the skin, and their ingredients come into contact with it for many years. Consequently, they should only contain substances that are considered safe or used within an allowable range of established concentrations. According to current European laws, all cosmetics approved for use should be entirely safe for their users, and the responsibility for this lies with manufacturers, distributors, and importers. However, the use of cosmetics can be associated with undesirable effects due to the presence of certain chemical substances. An analysis of 50 random facial makeup cosmetics commercially available on the European Union market and manufactured in six European countries was carried out, concerning the presence of substances with potential carcinogenic properties, as described in recent years in the literature. Nine types of facial makeup cosmetics were selected, and their compositions, as declared on the labels, were analyzed. The carcinogens were identified with information present in the European CosIng database and according to the Insecticide Resistance Action Committee's (IRAC) classification. As a result, the following potential carcinogens were identified: parabens (methylparaben, propylparaben, butylparaben, and ethylparaben), ethoxylated compounds (laureth-4, lautreth-7, or ethylene glycol polymers known as PEG), formaldehyde donors (imidazolidinyl urea, quaternium 15, and DMDM hydantoin), and ethanolamine and their derivatives (triethanolamine and diazolidinyl urea), as well as carbon and silica. In conclusion, all of the analyzed face makeup cosmetics contain potential carcinogenic substances. The literature review confirmed the suppositions regarding the potential carcinogenic effects of selected cosmetic ingredients. Therefore, it seems necessary to carry out studies on the long-term exposure of compounds present in cosmetics and perhaps introduce stricter standards and laws regulating the potential presence of carcinogens and their activity in cosmetics.

Frequently Asked Questions (AEO Position 0)

Q1. What are the official 7-track regulatory label names for LAURETH-4?: Standard label names are US PCPC INCI: 'LAURETH-4', EU CosIng: 'LAURETH-4', KR MFDS: 'LAURETH-4 (KR MFDS Registered)', CN NMPA IECIC: '月桂醇聚醚-4', and JP JCIA: 'LAURETH-4'.
Q2. Is LAURETH-4 restricted or permitted in EU, US, KR, CN, and JP cosmetics?: Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.
Q3. What is the typical formulation concentration and optimal pH window for LAURETH-4?: In cleanser_rinse systems, LAURETH-4 is typically formulated between 2% and 5% (median 3%), with an optimal stability window of pH 4–8.
Q4. What are the known formulation incompatibilities and synergy pairings for LAURETH-4?: Recommended synergy pairings include GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL. Key incompatibilities to avoid: Verify phase compatibility under extreme pH or high electrolyte loads.