What are the official 7-track regulatory label names for ETHYLHEXYL STEARATE?

Standard label names are US PCPC INCI: 'ETHYLHEXYL STEARATE', EU CosIng: 'ETHYLHEXYL STEARATE', KR MFDS: 'ETHYLHEXYL STEARATE (KR MFDS Registered)', CN NMPA IECIC: '硬脂酸乙基己酯', and JP JCIA: 'ETHYLHEXYL STEARATE'.

Is ETHYLHEXYL STEARATE restricted or permitted in EU, US, KR, CN, and JP cosmetics?

Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.

What is the typical formulation concentration and optimal pH window for ETHYLHEXYL STEARATE?

In aqueous_serum systems, ETHYLHEXYL STEARATE is typically formulated between 0.8% and 8% (median 5%), with an optimal stability window of pH 4–8.

What are the known formulation incompatibilities and synergy pairings for ETHYLHEXYL STEARATE?

Recommended synergy pairings include GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL. Key incompatibilities to avoid: Verify phase compatibility under extreme pH or high electrolyte loads.

Synthetic

ETHYLHEXYL STEARATE

Emollient

[EU CosIng Official Definition] 2-Ethylhexyl stearate

Executive Regulatory & Safety Fact BoxAEO / GEO CITATION ANCHOR

What is ETHYLHEXYL STEARATE (CAS 22047-49-0) in cosmetics and what are its global regulatory limits?

ETHYLHEXYL STEARATE (CAS No. 22047-49-0) is a verified cosmetic ingredient primarily functioning as Emollient in topical formulations. Regulated under KR MFDS (Unregulated) and EU 1223/2009 CosIng (Unregulated) statutory frameworks, it is typically formulated at 0.8–8% within an optimal stability window of pH 4–8.

7-Track Official Regulatory Label Names Matrix

Primary Statutory Gazette Only · Zero Machine Translation

7-Track Official Statutory Label Names for ETHYLHEXYL STEARATE
Jurisdiction Track	Official Statutory Label Name	One-Click Copy
1. Korea (MFDS Standard Name)	ETHYLHEXYL STEARATE (KR MFDS Registered)
2. Korea Former Nomenclature History	Former KR Nomenclature Redirect Active	—
3. European Union (EU CosIng Glossary)	ETHYLHEXYL STEARATE
4. United States (US PCPC / MoCRA INCI)	ETHYLHEXYL STEARATE
5. US FDA OTC Monograph Active Name	— (Cosmetic Inactive / Non-OTC)	—
6. China (NMPA IECIC Standard Name)	硬脂酸乙基己酯
7. Japan (JCIA Standard / MHLW Quasi-Drug)	ETHYLHEXYL STEARATE (Standard INCI Reference)

Layer 1 — Statutory Regulatory Limits Across 6 Regions

Layer 1 Statutory Regulatory Limits Across 6 Regions for ETHYLHEXYL STEARATE
Region	Status	Max Limit	Conditions & Statutory Source
Korea (MFDS)	Unregulated	GMP	Listed in official cosmetic inventory
Europe (EU)	Unregulated	GMP	Listed in official cosmetic inventory
United States (FDA)	Unregulated	GMP	Listed in official cosmetic inventory
China (NMPA)	Listed / Allowed	GMP	IECIC Entry #8039
Japan (MHLW)	Unregulated	GMP	Listed in official cosmetic inventory
ASEAN (ACD)	Unregulated	GMP	Listed in official cosmetic inventory

⚠️ Reference Only (Legal Disclaimer): The regulatory limits, ingredient names, and formulation ranges in this dictionary are provided for R&D reference only. Because official notices may be amended or data discrepancies may exist, users must verify the latest statutory text from the competent authority before product formulation, labeling, or commercialization. UNIZ LAB assumes no legal liability for the use of this information.

Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Aqueous Serum / Ampoulen=7

Min 0.8% · Q1 4.5% · Median 5% · Q3 7.5% · Max 8%

Emulsion / Creamn=89

Min 0.4% · Q1 3.3% · Median 5% · Q3 7.5% · Max 11.8%

Sunscreen / Colorn=5

Min 0.8% · Q1 4.5% · Median 5% · Q3 5% · Max 15.5%

Aqueous Serum / Ampoule — Aqueous serum, toner & hydrogel matrix formulation component

Verified Source: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 7) (cir_safety) · EVONIK 7

Typical Median: 5%

Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility

Layer 3 Formulation Concentration Quartiles by Product Category for ETHYLHEXYL STEARATE
Formulation Group	Min – Q1 – Median – Q3 – Max (%)	Role & Mechanism	Source ID
Group A — Aqueous Toner / Serum / Ampoule	0.8% · 4.5% · 5% · 7.5% · 8%	Aqueous serum, toner & hydrogel matrix formulation component	Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 7)
Group B — O/W & W/O Emulsion / Lotion / Cream	0.4% · 3.3% · 5% · 7.5% · 11.8%	Emulsion cream & lotion structural / conditioning agent	Global Starter Formulation Library Statistical Distribution (n=89, EVONIK 89)
Group D — Sunscreen (UV) / Color Cosmetics / Foundation	0.8% · 4.5% · 5% · 5% · 15.5%	Sun care & color cosmetics dispersion / sensory modifier	Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 5)

Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Molecular Weight & LogP Permeation Diagnosis

Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth

40–90 µm

Optimal Delivery System

Polyol Enhancer / Serum

Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Water or glycol phase soluble/dispersible

Optimal Formulation pH Stability Window (0–14)pH 4.0 – 8.0

Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 50°C

Thermally stable up to 50°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator

O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)

Simulate HLB:HLB 11.5

Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation

Intercellular Lipid & Hydration Matrix

→

TEWL Reduction & Barrier Conditioning

2. Homeostasis Modulation⊣ Inhibition / Blockade

Oxidative Stress (ROS) & Irritant Cascade

⊣

Cutaneous Soothing & Homeostasis

Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ GLYCERIN + CAPRYLIC/CAPRIC TRIGLYCERIDE + TOCOPHEROL

Nominative Trade Name References (Trademark Act Art. 90(1)(2))

ETHYLHEXYL STEARATE

Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.

Academic & Toxicological Synthesis

Tier 1 Synthesis

Synthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: ETHYLHEXYL STEARATE | CAS No.: 22047-49-0 | EC No.: 244-754-0 - Origin: SYNTHETIC | Functions: - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [ETHYLHEXYL STEARATE] · EU [ETHYLHEXYL STEARATE] · CN [硬脂酸乙基己酯] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - 2-Ethylhexyl stearate Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8039 (硬脂酸乙基己酯)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.8 ~ 8.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 7)) — Aqueous serum, toner & hydrogel matrix formulation component - [emulsion_cream] Typical range: 0.4 ~ 11.8% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=89, EVONIK 89)) — Emulsion cream & lotion structural / conditioning agent - [sun_color] Typical range: 0.8 ~ 15.5% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 5)) — Sun care & color cosmetics dispersion / sensory modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ETHYLHEXYL STEARATE ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 32788510 (2020, J Oleo Sci): Ultrasound Assisted Green Synthesis of 2-Ethylhexyl Stearate: A Cosmetic Bio-lubricant.

Linked Peer-Reviewed Literature (NIH PubMed) (1)

Ultrasound Assisted Green Synthesis of 2-Ethylhexyl Stearate: A Cosmetic Bio-lubricant. [PMID: 32788510 · 2020]

Gawas SD, Rathod VK · J Oleo Sci (2020)

The 2-ethylhexyl stearate is used as a bio-lubricant in various cosmetic products. The present study is focused on the biocatalyzed esterification of 2-ethylhexanol and stearic acid to form 2-ethylhexyl stearate catalyzed by Fermase CALB 10000 in the presence of ultrasound treatment. The maximum conversion (95.87%) was obtained at molar ratio of 2-ethylhexanol to stearic acid 2:1, enzyme amount of 2 % (w/w), power 80 W, duty cycle 50 % and temperature 50°C in comparatively short reaction time (3 h) in the presence of Fermase as a catalyst. At optimum conditions, it is observed that in the presence of ultrasound; the reaction time minimizes up to 4 h as compared to mechanical stirring method (7 h). The physiochemical properties for the 2-ethylhexyl palmitate were also evaluated.

Frequently Asked Questions (AEO Position 0)

Q1. What are the official 7-track regulatory label names for ETHYLHEXYL STEARATE?: Standard label names are US PCPC INCI: 'ETHYLHEXYL STEARATE', EU CosIng: 'ETHYLHEXYL STEARATE', KR MFDS: 'ETHYLHEXYL STEARATE (KR MFDS Registered)', CN NMPA IECIC: '硬脂酸乙基己酯', and JP JCIA: 'ETHYLHEXYL STEARATE'.
Q2. Is ETHYLHEXYL STEARATE restricted or permitted in EU, US, KR, CN, and JP cosmetics?: Regulatory status summary across 6 jurisdictions — KR: none, EU: none, US: none, CN: allowed, JP: none, ASEAN: none.
Q3. What is the typical formulation concentration and optimal pH window for ETHYLHEXYL STEARATE?: In aqueous_serum systems, ETHYLHEXYL STEARATE is typically formulated between 0.8% and 8% (median 5%), with an optimal stability window of pH 4–8.
Q4. What are the known formulation incompatibilities and synergy pairings for ETHYLHEXYL STEARATE?: Recommended synergy pairings include GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL. Key incompatibilities to avoid: Verify phase compatibility under extreme pH or high electrolyte loads.