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Ingredient Dictionary/diethylhexyl-butamido-triazone/DIETHYLHEXYL BUTAMIDO TRIAZONE
Tier 1 Monograph · SSOT 15 FieldsRaw .md (GEO) ↗
Synthetic

DIETHYLHEXYL BUTAMIDO TRIAZONE

UV FilterLight Stabilizer
[EU CosIng Official Definition] Diethylhexyl Butamido Triazone is the organic compound that conforms to the formula:
Executive Regulatory & Safety Fact BoxAEO / GEO CITATION ANCHOR

What is DIETHYLHEXYL BUTAMIDO TRIAZONE (CAS 154702-15-5) in cosmetics and what are its global regulatory limits?

DIETHYLHEXYL BUTAMIDO TRIAZONE (CAS No. 154702-15-5) is a verified cosmetic ingredient primarily functioning as UV Filter, Light Stabilizer in topical formulations. Regulated under KR MFDS (Restricted) and EU 1223/2009 CosIng (Restricted) statutory frameworks, it is typically formulated at 3–6% within an optimal stability window of pH 4–8.

7-Track Official Regulatory Label Names Matrix

Primary Statutory Gazette Only · Zero Machine Translation
7-Track Official Statutory Label Names for DIETHYLHEXYL BUTAMIDO TRIAZONE
Jurisdiction TrackOfficial Statutory Label NameOne-Click Copy
1. Korea (MFDS Standard Name)DIETHYLHEXYL BUTAMIDO TRIAZONE (KR MFDS Registered)
2. Korea Former Nomenclature History——
3. European Union (EU CosIng Glossary)DIETHYLHEXYL BUTAMIDO TRIAZONE
4. United States (US PCPC / MoCRA INCI)DIETHYLHEXYL BUTAMIDO TRIAZONE
5. US FDA OTC Monograph Active NameISCOTRIZINOL (UNAPPROVED OTC IN US)
6. China (NMPA IECIC Standard Name)二乙基己基丁酰胺基三嗪酮
7. Japan (JCIA Standard / MHLW Quasi-Drug)DIETHYLHEXYL BUTAMIDO TRIAZONE (Standard INCI Reference)

Layer 1 — Statutory Regulatory Limits Across 6 Regions

Layer 1 Statutory Regulatory Limits Across 6 Regions for DIETHYLHEXYL BUTAMIDO TRIAZONE
RegionStatusMax LimitConditions & Statutory Source
Korea (MFDS)RestrictedGMPListed in official cosmetic inventory
Europe (EU)RestrictedGMPListed in official cosmetic inventory
United States (FDA)UnregulatedGMPListed in official cosmetic inventory
China (NMPA)RestrictedGMPIECIC Entry #2218
Japan (MHLW)UnregulatedGMPListed in official cosmetic inventory
ASEAN (ACD)UnregulatedGMPListed in official cosmetic inventory
⚠️ Reference Only (Legal Disclaimer): The regulatory limits, ingredient names, and formulation ranges in this dictionary are provided for R&D reference only. Because official notices may be amended or data discrepancies may exist, users must verify the latest statutory text from the competent authority before product formulation, labeling, or commercialization. UNIZ LAB assumes no legal liability for the use of this information.
Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Sunscreen / Colorn=5
Min 3% · Q1 3% · Median 4.5% · Q3 5.5% · Max 6%
Sunscreen / Color — Sun care & color cosmetics dispersion / sensory modifier
Verified Source: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 5) (cir_safety) · EVONIK 5
Typical Median: 4.5%

Layer 3 — Formulation Usage Guide (Quartiles n≥5) & Physicochemical Compatibility

Layer 3 Formulation Concentration Quartiles by Product Category for DIETHYLHEXYL BUTAMIDO TRIAZONE
Formulation GroupMin – Q1 – Median – Q3 – Max (%)Role & MechanismSource ID
Group D — Sunscreen (UV) / Color Cosmetics / Foundation3% · 3% · 4.5% · 5.5% · 6%Sun care & color cosmetics dispersion / sensory modifierGlobal Starter Formulation Library Statistical Distribution (n=5, EVONIK 5)
Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Stratum Corneum (Brick & Mortar Barrier · 10–20 µm)500 Da Molecular Weight Cutoff BarrierViable Epidermis (Keratinocytes & Melanocytes · 50–100 µm)Target for Brightening (Tyrosinase/Melanosome) & Barrier LipidsPapillary Dermis (Fibroblasts & ECM Collagen · 150–300 µm)Target for Collagen I/III Synthesis, Peptides, PDRN & ExosomesEpidermal Passive Permeation (<500 Da)
Molecular Weight & LogP Permeation Diagnosis
Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth
40–90 µm
Optimal Delivery System
Polyol Enhancer / Serum
Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Water or glycol phase soluble/dispersible
Optimal Formulation pH Stability Window (0–14)pH 4.0 – 8.0
0245.5791114

Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 50°C
25°C45°C60°C75°C85°C100°C

Thermally stable up to 50°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator
O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)
HLB 11.5
W/O (3–6)Lamellar (8–10.5)O/W Emulsion (11–15)Solubilizer (15–19)O/W Droplet
Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation
Intercellular Lipid & Hydration Matrix
→
TEWL Reduction & Barrier Conditioning
2. Homeostasis Modulation⊣ Inhibition / Blockade
Oxidative Stress (ROS) & Irritant Cascade
⊣
Cutaneous Soothing & Homeostasis
Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

+ GLYCERIN+ CAPRYLIC/CAPRIC TR…+ TOCOPHEROL✕ Verify phase compati…DIETHYLHEXYL BUTAM…
Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ GLYCERIN+ CAPRYLIC/CAPRIC TRIGLYCERIDE+ TOCOPHEROL
Nominative Trade Name References (Trademark Act Art. 90(1)(2))
DIETHYLHEXYL BUTAMIDO TRIAZONE

Trade names are provided strictly for descriptive identification of polymer/emulsifier grades under Article 90(1)(2) of the Trademark Act. All trademarks belong to their respective owners.

Academic & Toxicological Synthesis

Tier 1 Synthesis

Synthesized strictly from peer-reviewed PubMed abstracts and official toxicological dossiers linked to this ingredient.

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: DIETHYLHEXYL BUTAMIDO TRIAZONE | CAS No.: 154702-15-5 | EC No.: N/A - Origin: SYNTHETIC | Functions: , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [DIETHYLHEXYL BUTAMIDO TRIAZONE] · EU [DIETHYLHEXYL BUTAMIDO TRIAZONE] · CN [二乙基己基丁酰胺基三嗪酮] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Diethylhexyl Butamido Triazone is the organic compound that conforms to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: NONE | CN: RESTRICTED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 2218 (二乙基己基丁酰胺基三嗪酮)) - [KR / COMPOSITION / limited] (Max 10%): - [CN / COMPOSITION / limited] (Max 10%): - [EU / COMPOSITION / limited] (Max 10%): - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [sun_color] Typical range: 3.0 ~ 6.0% (Median 4.5%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 5)) — Sun care & color cosmetics dispersion / sensory modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: DIETHYLHEXYL BUTAMIDO TRIAZONE ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

Linked Peer-Reviewed Literature (NIH PubMed) (0)

Statutory toxicology dossier verified via CosIng / MFDS / CIR compendia.

Frequently Asked Questions (AEO Position 0)

Q1. What are the official 7-track regulatory label names for DIETHYLHEXYL BUTAMIDO TRIAZONE?
Standard label names are US PCPC INCI: 'DIETHYLHEXYL BUTAMIDO TRIAZONE', EU CosIng: 'DIETHYLHEXYL BUTAMIDO TRIAZONE', KR MFDS: 'DIETHYLHEXYL BUTAMIDO TRIAZONE (KR MFDS Registered)', CN NMPA IECIC: '二乙基己基丁酰胺基三嗪酮', and JP JCIA: 'DIETHYLHEXYL BUTAMIDO TRIAZONE'.
Q2. Is DIETHYLHEXYL BUTAMIDO TRIAZONE restricted or permitted in EU, US, KR, CN, and JP cosmetics?
Regulatory status summary across 6 jurisdictions — KR: restricted, EU: restricted, US: none, CN: restricted, JP: none, ASEAN: none.
Q3. What is the typical formulation concentration and optimal pH window for DIETHYLHEXYL BUTAMIDO TRIAZONE?
In sun_color systems, DIETHYLHEXYL BUTAMIDO TRIAZONE is typically formulated between 3% and 6% (median 4.5%), with an optimal stability window of pH 4–8.
Q4. What are the known formulation incompatibilities and synergy pairings for DIETHYLHEXYL BUTAMIDO TRIAZONE?
Recommended synergy pairings include GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL. Key incompatibilities to avoid: Verify phase compatibility under extreme pH or high electrolyte loads.