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原料词典检索/polyglyceryl-3-diisostearate/POLYGLYCERYL-3 DIISOSTEARATE
Tier 1 Monograph · SSOT 15 FieldsRaw .md (GEO) ↗
化学合成 (Synthetic)

POLYGLYCERYL-3 DIISOSTEARATE

中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名: 聚甘油-3 二异硬脂酸酯 (序号 #3825)
乳化剂
[EU CosIng Official Definition] 1,2,3-Propanetriol, homopolymer, isodecanoates (1:2) (3 mol glycerol average molar ratio)
核心法规与安全结论 (Executive Fact Box)AEO / GEO CITATION ANCHOR

化妆品中 聚甘油-3 二异硬脂酸酯 (POLYGLYCERYL-3 DIISOSTEARATE) 的全球法规限值与配方应用标准是什么？

聚甘油-3 二异硬脂酸酯（标准 INCI: POLYGLYCERYL-3 DIISOSTEARATE，CAS 号: 66082-42-6）是化妆品配方中主要用作乳化剂的核心成分。受中国 NMPA（已使用/准用）、韩国 MFDS（未列管）及欧盟 CosIng（未列管）等 6 大法域法定标准监管，常规建议添加量为 0.5–3%（最佳稳定窗口 pH 4–8）。

全球 7 轨官方全成分标签名称对照表

严格采用各国政府官方目录原名 · 严禁机器翻译
7-Track Official Statutory Label Names for POLYGLYCERYL-3 DIISOSTEARATE
法域与监管轨道官方公告全成分标准名称一键复制
① 韩国 (MFDS 化妆品标准名称)POLYGLYCERYL-3 DIISOSTEARATE (KR MFDS Registered)
② 韩国旧名称历史 (301 重定向)Former KR Nomenclature Redirect Active—
③ 欧盟 (EU CosIng EC 1223/2009)POLYGLYCERYL-3 DIISOSTEARATE
④ 美国普通化妆品 (US PCPC / MoCRA INCI)POLYGLYCERYL-3 DIISOSTEARATE
⑤ 美国 OTC 防晒/祛痘专论活性物名称 (FDA OTC)— (非美国 OTC 专论活性成分 / 普通化妆品原料)—
⑥ 中国 (NMPA《已使用化妆品原料目录 IECIC》标准中文名)聚甘油-3 二异硬脂酸酯
⑦ 日本普通化妆品 / 医药部外品 (JCIA / MHLW)POLYGLYCERYL-3 DIISOSTEARATE (标准 INCI 参照)

Layer 1 — 全球 6 大法域法定限值与监管状态

Layer 1 Statutory Regulatory Limits Across 6 Regions for POLYGLYCERYL-3 DIISOSTEARATE
法域监管状态法定限值适用条件与法定依据来源
韩国 (MFDS)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
欧盟 (EU)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
美国 (FDA)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
中国 (NMPA)已使用/准用GMPIECIC Entry #3825
日本 (MHLW)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
东盟 (ACD)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
⚠️ 仅供参考 (免责声明): 本词典中的原料名称、法规限值与配比指南仅供研发参考。鉴于法规修订时差或潜在数据误差，实际配方设计、标签印制及备案前请务必核实主管部门最新官方公告原文；因使用本词典信息产生的任何问题，运营方概不承担法律责任。
Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Sunscreen / Colorn=5
Min 0.5% · Q1 0.5% · Median 1% · Q3 2% · Max 3%
Sunscreen / Color — Sun care & color cosmetics dispersion / sensory modifier
Verified Source: Global Starter Formulation Library Statistical Distribution (n=5, GRANT 4 · ELEMENTIS 1) (cir_safety) · GRANT 4 · ELEMENTIS 1
Typical Median: 1%

Layer 3 — 剂型常规配比指南与理化配伍性

Layer 3 Formulation Concentration Quartiles by Product Category for POLYGLYCERYL-3 DIISOSTEARATE
剂型分类Min – Q1 – Median – Q3 – Max (%)配方作用与机理Source ID
剂型组 D — 防晒霜 / 彩妆 / 粉底0.5% · 0.5% · 1% · 2% · 3%Sun care & color cosmetics dispersion / sensory modifierGlobal Starter Formulation Library Statistical Distribution (n=5, GRANT 4 · ELEMENTIS 1)
Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Stratum Corneum (Brick & Mortar Barrier · 10–20 µm)500 Da Molecular Weight Cutoff BarrierViable Epidermis (Keratinocytes & Melanocytes · 50–100 µm)Target for Brightening (Tyrosinase/Melanosome) & Barrier LipidsPapillary Dermis (Fibroblasts & ECM Collagen · 150–300 µm)Target for Collagen I/III Synthesis, Peptides, PDRN & ExosomesEpidermal Passive Permeation (<500 Da)
Molecular Weight & LogP Permeation Diagnosis
Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth
40–90 µm
Optimal Delivery System
Polyol Enhancer / Serum
Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Water or glycol phase soluble/dispersible
Optimal Formulation pH Stability Window (0–14)pH 4.0 – 8.0
0245.5791114

Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 50°C
25°C45°C60°C75°C85°C100°C

Thermally stable up to 50°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator
O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)
HLB 11.5
W/O (3–6)Lamellar (8–10.5)O/W Emulsion (11–15)Solubilizer (15–19)O/W Droplet
Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation
Intercellular Lipid & Hydration Matrix
→
TEWL Reduction & Barrier Conditioning
2. Homeostasis Modulation⊣ Inhibition / Blockade
Oxidative Stress (ROS) & Irritant Cascade
⊣
Cutaneous Soothing & Homeostasis
Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

+ GLYCERIN+ CAPRYLIC/CAPRIC TR…+ TOCOPHEROL✕ Verify phase compati…POLYGLYCERYL-3 DII…
Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ GLYCERIN+ CAPRYLIC/CAPRIC TRIGLYCERIDE+ TOCOPHEROL
代表性商品名参考 (商标法第90条第1款第2项说明性标示)
POLYGLYCERYL-3 DIISOSTEARATE

商品名仅供配方师识别原料规格参考，商标权归各原厂商所有。

学术与毒理综合摘要

Tier 1 Synthesis

本综述严格基于与该原料关联的 NIH PubMed 同行评审文献摘要及官方毒理学评估档案编写。

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: POLYGLYCERYL-3 DIISOSTEARATE | CAS No.: 66082-42-6 | EC No.: N/A - Origin: SYNTHETIC | Functions: - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [POLYGLYCERYL-3 DIISOSTEARATE] · EU [POLYGLYCERYL-3 DIISOSTEARATE] · CN [聚甘油-3 二异硬脂酸酯] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - 1,2,3-Propanetriol, homopolymer, isodecanoates (1:2) (3 mol glycerol average molar ratio) Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3825 (聚甘油-3 二异硬脂酸酯)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [sun_color] Typical range: 0.5 ~ 3.0% (Median 1.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, GRANT 4 · ELEMENTIS 1)) — Sun care & color cosmetics dispersion / sensory modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: POLYGLYCERYL-3 DIISOSTEARATE ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 40745200 (2025, Sci Rep): Protective effects of avocado peel and seed extracts against UVB-damaged fibroblasts for the development of an anti-phot

关联同行评审文献 (NIH PubMed) (1)

Protective effects of avocado peel and seed extracts against UVB-damaged fibroblasts for the development of an anti-photoaging nanoemulgel. [PMID: 40745200 · 2025]
Thungmungmee S, Wisidsri N · Sci Rep (2025)

This study investigates the anti-photoaging potential of ethanolic extracts from avocado peel and seed and their application in a nanoemulgel formulation. Both extracts demonstrated high phenolic content and strong antioxidant activity, with DPPH IC 50 values of 57.05&#x2009;&#xb1;&#x2009;1.65&#xa0;&#xb5;g/ml (peel) and 52.44&#x2009;&#xb1;&#x2009;0.32&#xa0;&#xb5;g/ml (seed). In UVB-irradiated human dermal fibroblasts (BJ cells), the extracts (12.5-50&#xa0;&#xb5;g/ml) significantly reduced intracellular ROS, decreased MMP-1 and pro-inflammatory cytokines (TNF-&#x3b1;, IL-1&#x3b2;, IL-6), and restored collagen levels. A nanoemulgel was developed using the phase inversion composition (PIC) method, with avocado oil, isononyl isononanoate, Tween 60, and polyglyceryl-3 diisostearate, which resulted in nanoemulsions (NEs) with an average droplet size of 84.45&#x2009;&#xb1;&#x2009;5.45&#xa0;nm and a zeta potential of -69.94&#x2009;&#xb1;&#x2009;5.66 mV. Incorporation of 0.5% Aqupec HV-505E and avocado extracts produced stable, light green gel. The resulting avocado extract-loaded nanoemulgel (ANE) demonstrated antioxidant activity, cytocompatibility with BJ cells, and stability in terms of color, pH, and viscosity. These findings reveal the anti-aging potential of avocado peel and seed extracts in preserving effectiveness within nanoemulgel for skin applications.

常见问题解答 (FAQ)

Q1. 聚甘油-3 二异硬脂酸酯 (POLYGLYCERYL-3 DIISOSTEARATE) 在全球 7 大法域的官方全成分标签名称是什么？
中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名为 '聚甘油-3 二异硬脂酸酯'，美国 PCPC 与欧盟 CosIng 标准 INCI 为 'POLYGLYCERYL-3 DIISOSTEARATE'，日本 JCIA 表示名称为 'POLYGLYCERYL-3 DIISOSTEARATE'。
Q2. 聚甘油-3 二异硬脂酸酯 (POLYGLYCERYL-3 DIISOSTEARATE) 在中、韩、欧、美、日、东盟的法定监管状态 (Layer 1) 如何？
6 大法域监管汇总 — 中国(CN): allowed，韩国(KR): none，欧盟(EU): none，美国(US): none，日本(JP): none，东盟(ASEAN): none。
Q3. 聚甘油-3 二异硬脂酸酯 (POLYGLYCERYL-3 DIISOSTEARATE) 的常规配方添加量 (Layer 3) 与最佳稳定 pH 窗口是多少？
在代表性剂型 (sun_color) 中常规添加量为 0.5%–3%（中位数 1%），最佳稳定 pH 范围为 4–8。
Q4. 聚甘油-3 二异硬脂酸酯 (POLYGLYCERYL-3 DIISOSTEARATE) 有哪些配伍禁忌 (Incompatibilities) 与协同增效组合？
推荐协同组合包括 GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL；配伍禁忌注意：Verify phase compatibility under extreme pH or high electrolyte loads。