METHYL METHACRYLATE CROSSPOLYMER
化妆品中 甲基丙烯酸甲酯交联聚合物 (METHYL METHACRYLATE CROSSPOLYMER) 的全球法规限值与配方应用标准是什么？
甲基丙烯酸甲酯交联聚合物（标准 INCI: METHYL METHACRYLATE CROSSPOLYMER，CAS 号: 25777-71-3）是化妆品配方中主要用作成膜剂的核心成分。受中国 NMPA（已使用/准用）、韩国 MFDS（未列管）及欧盟 CosIng（未列管）等 6 大法域法定标准监管，常规建议添加量为 0.5–10%（最佳稳定窗口 pH 4–8）。
全球 7 轨官方全成分标签名称对照表
严格采用各国政府官方目录原名 · 严禁机器翻译| 法域与监管轨道 | 官方公告全成分标准名称 | 一键复制 |
|---|---|---|
| ① 韩国 (MFDS 化妆品标准名称) | METHYL METHACRYLATE CROSSPOLYMER (KR MFDS Registered) | |
| ② 韩国旧名称历史 (301 重定向) | Former KR Nomenclature Redirect Active | — |
| ③ 欧盟 (EU CosIng EC 1223/2009) | METHYL METHACRYLATE CROSSPOLYMER | |
| ④ 美国普通化妆品 (US PCPC / MoCRA INCI) | METHYL METHACRYLATE CROSSPOLYMER | |
| ⑤ 美国 OTC 防晒/祛痘专论活性物名称 (FDA OTC) | — (非美国 OTC 专论活性成分 / 普通化妆品原料) | — |
| ⑥ 中国 (NMPA《已使用化妆品原料目录 IECIC》标准中文名) | 甲基丙烯酸甲酯交联聚合物 | |
| ⑦ 日本普通化妆品 / 医药部外品 (JCIA / MHLW) | METHYL METHACRYLATE CROSSPOLYMER (标准 INCI 参照) |
Layer 1 — 全球 6 大法域法定限值与监管状态
| 法域 | 监管状态 | 法定限值 | 适用条件与法定依据来源 |
|---|---|---|---|
| 韩国 (MFDS) | 未列管 | GMP | 已列入官方化妆品原料目录 (按 GMP 规范使用) |
| 欧盟 (EU) | 未列管 | GMP | 已列入官方化妆品原料目录 (按 GMP 规范使用) |
| 美国 (FDA) | 未列管 | GMP | 已列入官方化妆品原料目录 (按 GMP 规范使用) |
| 中国 (NMPA) | 已使用/准用 | GMP | IECIC Entry #3295 |
| 日本 (MHLW) | 未列管 | GMP | 已列入官方化妆品原料目录 (按 GMP 规范使用) |
| 东盟 (ACD) | 未列管 | GMP | 已列入官方化妆品原料目录 (按 GMP 规范使用) |
Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit
Layer 3 — 剂型常规配比指南与理化配伍性
| 剂型分类 | Min – Q1 – Median – Q3 – Max (%) | 配方作用与机理 | Source ID |
|---|---|---|---|
| 剂型组 B — 乳液 / 面霜 (O/W · W/O) | 0.5% · 1% · 3% · 8% · 10% | Emulsion cream & lotion structural / conditioning agent | Global Starter Formulation Library Statistical Distribution (n=8, SEPPIC 8) |
Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery
Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.
pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior
Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.
Thermally stable up to 50°C during standard emulsification.
Cellular & Molecular Target Mechanism Flow
Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)
Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.
商品名仅供配方师识别原料规格参考，商标权归各原厂商所有。
学术与毒理综合摘要
Tier 1 Synthesis本综述严格基于与该原料关联的 NIH PubMed 同行评审文献摘要及官方毒理学评估档案编写。
关联同行评审文献 (NIH PubMed) (2)
Final report of the Cosmetic Ingredient Review Expert Panel safety assessment of polymethyl methacrylate (PMMA), methyl methacrylate crosspolymer, and methyl methacrylate/glycol dimethacrylate crosspolymer. [PMID: 21772027 · 2011]
Polymethyl methacrylate (PMMA) and related cosmetic ingredients methyl methacrylate crosspolymer and methyl methacrylate/glycol dimethacrylate crosspolymer are polymers that function as film formers and viscosity-increasing agents in cosmetics. The Food and Drug Administration (FDA) determination of safety of PMMA use in several medical devices, which included human and animal safety data, was used as the basis of safety of PMMA and related polymers in cosmetics by the Cosmetic Ingredient Review (CIR) Expert Panel.  The PMMA used in cosmetics is substantially the same as in medical devices.  The Panel concluded that these ingredients are safe as cosmetic ingredients in the practices of use and concentrations as described in this safety assessment.
Synergistic/antagonistic antimicrobial effects of cosmetic ingredients in combination with 1,2-hexanediol. [PMID: 39805611 · 2024]
With the rise of the clean beauty trend in the cosmetics and personal care industry, consumers' interest in cosmetic ingredients, especially preservatives, continues to grow. Paraben, previously the most used preservative in cosmetics, has been excluded from many products owing to its potential risks. Therefore, a movement to lower the content of various preservatives is ongoing. One approach to achieve a suitable level of preservation is to use multifunctional ingredients as preservative boosters. In this study, we aimed to confirm the synergistic antimicrobial interactions between various cosmetic ingredients and 1,2-hexanediol, a preservative introduced as a substitute for paraben, using the checkerboard assay. We also measured the antagonistic effect by measuring the fold changes in the minimum inhibitory concentration of 1,2-hexanediol. Niacinamide, a form of vitamin B3, showed synergistic antifungal activity with 1,2-hexanediol, which lowered the content of 1,2-hexanediol in the oil-solubilized toner formulation. Among the substances, 50000 ppm of methyl methacrylate crosspolymer elevated the minimum inhibitory concentration of 1,2-hexanediol against bacteria and fungi by 2‒8 times. Through this study, we suggest applying the synergistic effects of various cosmetic ingredients in the formulation as a method to effectively reduce the content of preservatives.
常见问题解答 (FAQ)
- Q1. 甲基丙烯酸甲酯交联聚合物 (METHYL METHACRYLATE CROSSPOLYMER) 在全球 7 大法域的官方全成分标签名称是什么？
- 中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名为 '甲基丙烯酸甲酯交联聚合物'，美国 PCPC 与欧盟 CosIng 标准 INCI 为 'METHYL METHACRYLATE CROSSPOLYMER'，日本 JCIA 表示名称为 'METHYL METHACRYLATE CROSSPOLYMER'。
- Q2. 甲基丙烯酸甲酯交联聚合物 (METHYL METHACRYLATE CROSSPOLYMER) 在中、韩、欧、美、日、东盟的法定监管状态 (Layer 1) 如何？
- 6 大法域监管汇总 — 中国(CN): allowed，韩国(KR): none，欧盟(EU): none，美国(US): none，日本(JP): none，东盟(ASEAN): none。
- Q3. 甲基丙烯酸甲酯交联聚合物 (METHYL METHACRYLATE CROSSPOLYMER) 的常规配方添加量 (Layer 3) 与最佳稳定 pH 窗口是多少？
- 在代表性剂型 (emulsion_cream) 中常规添加量为 0.5%–10%（中位数 3%），最佳稳定 pH 范围为 4–8。
- Q4. 甲基丙烯酸甲酯交联聚合物 (METHYL METHACRYLATE CROSSPOLYMER) 有哪些配伍禁忌 (Incompatibilities) 与协同增效组合？
- 推荐协同组合包括 GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL；配伍禁忌注意：Verify phase compatibility under extreme pH or high electrolyte loads。