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原料词典检索/laureth-4/LAURETH-4
Tier 1 Monograph · SSOT 15 FieldsRaw .md (GEO) ↗
化学合成 (Synthetic)

LAURETH-4

中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名: 月桂醇聚醚-4 (序号 #8305)
抗静电剂香精 / 香料乳化剂清洁剂
[EU CosIng Official Definition] 3,6,9,12-tetraoxatetracosan-1-ol; Dodecan-1-ol, ethoxylated; Alcohols, C12-14, ethoxylated
核心法规与安全结论 (Executive Fact Box)AEO / GEO CITATION ANCHOR

化妆品中 月桂醇聚醚-4 (LAURETH-4) 的全球法规限值与配方应用标准是什么？

月桂醇聚醚-4（标准 INCI: LAURETH-4，CAS 号: 5274-68-0）是化妆品配方中主要用作抗静电剂, 香精 / 香料, 乳化剂的核心成分。受中国 NMPA（已使用/准用）、韩国 MFDS（未列管）及欧盟 CosIng（未列管）等 6 大法域法定标准监管，常规建议添加量为 2–5%（最佳稳定窗口 pH 4–8）。

全球 7 轨官方全成分标签名称对照表

严格采用各国政府官方目录原名 · 严禁机器翻译
7-Track Official Statutory Label Names for LAURETH-4
法域与监管轨道官方公告全成分标准名称一键复制
① 韩国 (MFDS 化妆品标准名称)LAURETH-4 (KR MFDS Registered)
② 韩国旧名称历史 (301 重定向)——
③ 欧盟 (EU CosIng EC 1223/2009)LAURETH-4
④ 美国普通化妆品 (US PCPC / MoCRA INCI)LAURETH-4
⑤ 美国 OTC 防晒/祛痘专论活性物名称 (FDA OTC)— (非美国 OTC 专论活性成分 / 普通化妆品原料)—
⑥ 中国 (NMPA《已使用化妆品原料目录 IECIC》标准中文名)月桂醇聚醚-4
⑦ 日本普通化妆品 / 医药部外品 (JCIA / MHLW)LAURETH-4 (标准 INCI 参照)

Layer 1 — 全球 6 大法域法定限值与监管状态

Layer 1 Statutory Regulatory Limits Across 6 Regions for LAURETH-4
法域监管状态法定限值适用条件与法定依据来源
韩国 (MFDS)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
欧盟 (EU)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
美国 (FDA)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
中国 (NMPA)已使用/准用GMPIECIC Entry #8305
日本 (MHLW)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
东盟 (ACD)未列管GMP已列入官方化妆品原料目录 (按 GMP 规范使用)
⚠️ 仅供参考 (免责声明): 本词典中的原料名称、法规限值与配比指南仅供研发参考。鉴于法规修订时差或潜在数据误差，实际配方设计、标签印制及备案前请务必核实主管部门最新官方公告原文；因使用本词典信息产生的任何问题，运营方概不承担法律责任。
Interactive Quartile Box-Plot (Min–Q1–Median–Q3–Max)

Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit

Rinse-off Cleansern=6
Min 2% · Q1 2% · Median 3% · Q3 4% · Max 5%
Emulsion / Creamn=6
Min 1% · Q1 1.875% · Median 3% · Q3 3% · Max 4%
Rinse-off Cleanser — Rinse-off cleanser & surfactant system modifier
Verified Source: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 4 · ELEMENTIS 2) (cir_safety) · EVONIK 4 · ELEMENTIS 2
Typical Median: 3%

Layer 3 — 剂型常规配比指南与理化配伍性

Layer 3 Formulation Concentration Quartiles by Product Category for LAURETH-4
剂型分类Min – Q1 – Median – Q3 – Max (%)配方作用与机理Source ID
剂型组 C — 淋洗类洁面 / 洗发水 / 沐浴露2% · 2% · 3% · 4% · 5%Rinse-off cleanser & surfactant system modifierGlobal Starter Formulation Library Statistical Distribution (n=6, EVONIK 4 · ELEMENTIS 2)
剂型组 B — 乳液 / 面霜 (O/W · W/O)1% · 1.875% · 3% · 3% · 4%Emulsion cream & lotion structural / conditioning agentGlobal Starter Formulation Library Statistical Distribution (n=6, EVONIK 5 · GRANT 1)
Cutaneous Permeation Science (500 Dalton Rule)MW: Macro/Complex · LogP: N/A

Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery

Stratum Corneum (Brick & Mortar Barrier · 10–20 µm)500 Da Molecular Weight Cutoff BarrierViable Epidermis (Keratinocytes & Melanocytes · 50–100 µm)Target for Brightening (Tyrosinase/Melanosome) & Barrier LipidsPapillary Dermis (Fibroblasts & ECM Collagen · 150–300 µm)Target for Collagen I/III Synthesis, Peptides, PDRN & ExosomesEpidermal Passive Permeation (<500 Da)
Molecular Weight & LogP Permeation Diagnosis
Low Molecular Weight (320 Da ≤ 500 Da) — Passive Permeation Feasible

Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.

Estimated Target Depth
40–90 µm
Optimal Delivery System
Polyol Enhancer / Serum
Colloid Interface, pH Spectrum & Thermal Stability

pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior

Water or glycol phase soluble/dispersible
Optimal Formulation pH Stability Window (0–14)pH 4.0 – 8.0
0245.5791114

Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.

Maximum Thermal Processing Limit (°C)≤ 50°C
25°C45°C60°C75°C85°C100°C

Thermally stable up to 50°C during standard emulsification.

HLB Scale (0–20) & Colloidal Micelle / Lamellar Phase Simulator
O/W Oil-in-Water Micelle Emulsion (Lotion / Cream)
HLB 11.5
W/O (3–6)Lamellar (8–10.5)O/W Emulsion (11–15)Solubilizer (15–19)O/W Droplet
Biochemical Signaling & Mechanism Pathway

Cellular & Molecular Target Mechanism Flow

1. Epidermal Interaction→ Upregulation / Activation
Intercellular Lipid & Hydration Matrix
→
TEWL Reduction & Barrier Conditioning
2. Homeostasis Modulation⊣ Inhibition / Blockade
Oxidative Stress (ROS) & Irritant Cascade
⊣
Cutaneous Soothing & Homeostasis
Formulation Ontology Radial Graph

Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)

+ GLYCERIN+ CAPRYLIC/CAPRIC TR…+ TOCOPHEROL✕ Verify phase compati…LAURETH-4
Interactive Node Guide

Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.

+ GLYCERIN+ CAPRYLIC/CAPRIC TRIGLYCERIDE+ TOCOPHEROL
代表性商品名参考 (商标法第90条第1款第2项说明性标示)
LAURETH-4

商品名仅供配方师识别原料规格参考，商标权归各原厂商所有。

学术与毒理综合摘要

Tier 1 Synthesis

本综述严格基于与该原料关联的 NIH PubMed 同行评审文献摘要及官方毒理学评估档案编写。

■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: LAURETH-4 | CAS No.: 5274-68-0 | EC No.: 226-097-1 - Origin: SYNTHETIC | Functions: , , , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [LAURETH-4] · EU [LAURETH-4] · CN [月桂醇聚醚-4] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - 3,6,9,12-tetraoxatetracosan-1-ol; Dodecan-1-ol, ethoxylated; Alcohols, C12-14, ethoxylated Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8305 (月桂醇聚醚-4)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [cleanser_rinse] Typical range: 2.0 ~ 5.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 4 · ELEMENTIS 2)) — Rinse-off cleanser & surfactant system modifier - [emulsion_cream] Typical range: 1.0 ~ 4.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 5 · GRANT 1)) — Emulsion cream & lotion structural / conditioning agent ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: LAURETH-4 ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 36981689 (2023, Int J Environ Res Public Health): Potential Carcinogens in Makeup Cosmetics.

关联同行评审文献 (NIH PubMed) (1)

Potential Carcinogens in Makeup Cosmetics. [PMID: 36981689 · 2023]
Balwierz R, Biernat P, Jasi&#x144;ska-Balwierz A, Siod&#x142;ak D, Kusakiewicz-Dawid A, Kurek-G&#xf3;recka A, Olczyk P, Och&#x119;dzan-Siod&#x142;ak W · Int J Environ Res Public Health (2023)

Facial makeup cosmetics are commonly used products that are applied to the skin, and their ingredients come into contact with it for many years. Consequently, they should only contain substances that are considered safe or used within an allowable range of established concentrations. According to current European laws, all cosmetics approved for use should be entirely safe for their users, and the responsibility for this lies with manufacturers, distributors, and importers. However, the use of cosmetics can be associated with undesirable effects due to the presence of certain chemical substances. An analysis of 50 random facial makeup cosmetics commercially available on the European Union market and manufactured in six European countries was carried out, concerning the presence of substances with potential carcinogenic properties, as described in recent years in the literature. Nine types of facial makeup cosmetics were selected, and their compositions, as declared on the labels, were analyzed. The carcinogens were identified with information present in the European CosIng database and according to the Insecticide Resistance Action Committee's (IRAC) classification. As a result, the following potential carcinogens were identified: parabens (methylparaben, propylparaben, butylparaben, and ethylparaben), ethoxylated compounds (laureth-4, lautreth-7, or ethylene glycol polymers known as PEG), formaldehyde donors (imidazolidinyl urea, quaternium 15, and DMDM hydantoin), and ethanolamine and their derivatives (triethanolamine and diazolidinyl urea), as well as carbon and silica. In conclusion, all of the analyzed face makeup cosmetics contain potential carcinogenic substances. The literature review confirmed the suppositions regarding the potential carcinogenic effects of selected cosmetic ingredients. Therefore, it seems necessary to carry out studies on the long-term exposure of compounds present in cosmetics and perhaps introduce stricter standards and laws regulating the potential presence of carcinogens and their activity in cosmetics.

常见问题解答 (FAQ)

Q1. 月桂醇聚醚-4 (LAURETH-4) 在全球 7 大法域的官方全成分标签名称是什么？
中国 NMPA《已使用化妆品原料目录 (IECIC)》标准中文名为 '月桂醇聚醚-4'，美国 PCPC 与欧盟 CosIng 标准 INCI 为 'LAURETH-4'，日本 JCIA 表示名称为 'LAURETH-4'。
Q2. 月桂醇聚醚-4 (LAURETH-4) 在中、韩、欧、美、日、东盟的法定监管状态 (Layer 1) 如何？
6 大法域监管汇总 — 中国(CN): allowed，韩国(KR): none，欧盟(EU): none，美国(US): none，日本(JP): none，东盟(ASEAN): none。
Q3. 月桂醇聚醚-4 (LAURETH-4) 的常规配方添加量 (Layer 3) 与最佳稳定 pH 窗口是多少？
在代表性剂型 (cleanser_rinse) 中常规添加量为 2%–5%（中位数 3%），最佳稳定 pH 范围为 4–8。
Q4. 月桂醇聚醚-4 (LAURETH-4) 有哪些配伍禁忌 (Incompatibilities) 与协同增效组合？
推荐协同组合包括 GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL；配伍禁忌注意：Verify phase compatibility under extreme pH or high electrolyte loads。