ETHYLHEXYL PALMITATE
化粧品における ETHYLHEXYL PALMITATE のグローバル配合基準と処方特性とは？
ETHYLHEXYL PALMITATE（CAS番号: 29806-73-3）は、化粧品処方において主にエモリエント剤, 香料として配合される原料です。日本厚労省/JCIA（規制なし）、韓国MFDS（規制なし）、欧州CosIng（規制なし）など6大法域の法定基準下で管理され、通常 3–15%（適正安定域 pH 4–8）で処方されます。
7大トラック 国別・用途別 公式全成分表示名称マトリクス
各国公的告示原典のみ収録 · 機械翻訳・任意音訳ゼロ| 法域・規制トラック | 公式全成分表示名称 | ワンクリックコピー |
|---|---|---|
| ① 韓国 (MFDS 化粧品標準名称) | ETHYLHEXYL PALMITATE (KR MFDS Registered) | |
| ② 韓国旧名称履歴 (301 リダイレクト) | Former KR Nomenclature Redirect Active | — |
| ③ 欧州連合 (EU CosIng EC 1223/2009) | ETHYLHEXYL PALMITATE | |
| ④ 米国一般化粧品 (US PCPC / MoCRA INCI) | ETHYLHEXYL PALMITATE | |
| ⑤ 米国 FDA OTC モノグラフ有効成分名 | — (米国 OTC 対象外 / 一般化粧品原料) | — |
| ⑥ 中国 (NMPA IECIC 標準中国語名称) | 棕榈酸乙基己酯 | |
| ⑦ 日本化粧品表示名称 / 医薬部外品外原規名称 (JCIA / MHLW) | ETHYLHEXYL PALMITATE (標準INCI参照 · 任意カタカナ音訳排除) |
Layer 1 — 6大法域 法定配合上限および規制ステータス
| 法域 | 規制ステータス | 配合上限 | 制限条件および一次法源出典 |
|---|---|---|---|
| 韓国 (MFDS) | 規制なし | GMP | 公的化粧品原料目録収載 (GMP基準内使用) |
| 欧州 (EU) | 規制なし | GMP | 公的化粧品原料目録収載 (GMP基準内使用) |
| 米国 (FDA) | 規制なし | GMP | 公的化粧品原料目録収載 (GMP基準内使用) |
| 中国 (NMPA) | 配合可能 | GMP | IECIC Entry #8716 |
| 日本 (MHLW) | 規制なし | GMP | 公的化粧品原料目録収載 (GMP基準内使用) |
| ASEAN (ACD) | 規制なし | GMP | 公的化粧品原料目録収載 (GMP基準内使用) |
Layer 3 Formulation Concentration Box-Plot vs. Statutory Limit
Layer 3 — 剤形別通常配合濃度 (四分位数 n≥5) & 物理化学・相溶性ガイド
| 剤形グループ | Min – Q1 – Median – Q3 – Max (%) | 処方役割・作用機序 | Source ID |
|---|---|---|---|
| 剤形群 A — 水성化粧水・美容液・アンプル | 3% · 7.025% · 11.35% · 14.4% · 15% | Aqueous serum, toner & hydrogel matrix formulation component | Global Starter Formulation Library Statistical Distribution (n=6, SEPPIC 3 · GRANT 2 · ELEMENTIS 1) |
| 剤形群 B — 乳液・エマルジョン・クリーム | 3% · 3.5% · 5% · 7.35% · 7.7% | Emulsion cream & lotion structural / conditioning agent | Global Starter Formulation Library Statistical Distribution (n=7, GRANT 5 · EVONIK 1 · SEPPIC 1) |
| 剤形群 D — 日焼け止め (UV)・メイクアップ・ファンデーション | 3% · 4.75% · 5% · 6.0875% · 8% | Sun care & color cosmetics dispersion / sensory modifier | Global Starter Formulation Library Statistical Distribution (n=8, GRANT 7 · ELEMENTIS 1) |
Stratum Corneum Penetration Depth & Bio-Spicule Transdermal Delivery
Under passive topical application, molecules diffuse tortuously through intercellular lipids. Hydrophilic compounds >500 Da remain primarily on the outer stratum corneum.
pH Stability Window (0–14), Thermal Limit & HLB Colloidal Phase Behavior
Outside pH 4–8, risk of hydrolysis, viscosity loss, or ionic dissociation increases.
Thermally stable up to 50°C during standard emulsification.
Cellular & Molecular Target Mechanism Flow
Interactive Synergy Pairings (Solid) & Incompatibility Warnings (Dashed)
Click any green synergy node to jump directly to its monograph, or click a red dashed node to inspect the chemical incompatibility mechanism.
商品名は研究者がグレードを識別するための参考表記であり、各商標権は原メーカーに帰属します。
学術・毒性・処方統合モノグラフ
Tier 1 Synthesis本原料に紐づく NIH PubMed 査読付き論文アブストラクトおよび公的毒性評価報告書のみに基づいて作成された学術要約です。
関連査読付き学術論文 (NIH PubMed) (5)
Ultrasound Assisted Green Synthesis of 2-Ethylhexyl Stearate: A Cosmetic Bio-lubricant. [PMID: 32788510 · 2020]
The 2-ethylhexyl stearate is used as a bio-lubricant in various cosmetic products. The present study is focused on the biocatalyzed esterification of 2-ethylhexanol and stearic acid to form 2-ethylhexyl stearate catalyzed by Fermase CALB 10000 in the presence of ultrasound treatment. The maximum conversion (95.87%) was obtained at molar ratio of 2-ethylhexanol to stearic acid 2:1, enzyme amount of 2 % (w/w), power 80 W, duty cycle 50 % and temperature 50°C in comparatively short reaction time (3 h) in the presence of Fermase as a catalyst. At optimum conditions, it is observed that in the presence of ultrasound; the reaction time minimizes up to 4 h as compared to mechanical stirring method (7 h). The physiochemical properties for the 2-ethylhexyl palmitate were also evaluated.
Vibrational spectroscopy coupled to classical least square analysis, a new approach for determination of skin moisturizing agents' mechanisms. [PMID: 24256135 · 2014]
Skin dryness is an omnipresent symptom in various types of skin disorders. Thereby, a large panel of skin care products is developed for therapeutic purposes. However, there is still a lack of non-invasive methods to determine the mechanisms of action of moisturizers at the molecular level. In the present study, confocal Raman spectroscopy coupled to classical least square analyses and ATR-FTIR were used to investigate the effect of different molecules on the stratum corneum (SC) hydration degree and barrier state. First, hygroscopic property was determined by analyzing samples at 90% RH; secondly, the water barrier function was evaluated after the dehydration process (4% RH). The molecules penetration kinetics across SC were also studied for 2 h. Using the present approach, glycerin and propylene glycol were found to be humectants; lanoline showed occlusive action, lactic acid has both humectant and barrier enhancer properties, and ethylhexyl palmitate and caprylic/capric acid triglyceride seemed to be emollients. These observations are in accordance with literature. The present method non-invasively characterizes the mechanism of action of tested molecules. This may improve knowledge of new molecules' structure-activity relationship and help make an effective therapeutic concept dealing with the various skin dysfunctions.
Compound allergy to Vea Oil [PMID: 14996082 · 2003]
Monographs on fragrance raw materials [PMID: 7286874 · 1981]
Synthesis of 2-Ethylhexyl Palmitate Catalyzed by Enzyme Under Microwave [PMID: 29152693 · 2018]
2-Ethylhexyl palmitate has been prepared in organic solvents catalyzed by an immobilized lipase QLM. Microwave irradiation was used to improve the enzyme activity and shorten the reaction time. The reaction conditions under microwave have been optimized. Compared with that of the free QLM under classical heating, the immobilized QLM under microwave exhibited higher enzyme activity and the conversion could achieve 99% in about 3.0 h. Furthermore, the immobilized QLM displayed excellent reusability under microwave irradiation.
よくある質問 (FAQ)
- Q1. ETHYLHEXYL PALMITATE の各国公式全成分表示名称（7トラック）はどのように異なりますか？
- 日本化粧品工業連合会(JCIA)表示名称は 'ETHYLHEXYL PALMITATE (標準INCI準拠)'、米国PCPC・欧州CosIng INCIは 'ETHYLHEXYL PALMITATE'、中国NMPA IECIC標準中国語名は '棕榈酸乙基己酯' です。
- Q2. ETHYLHEXYL PALMITATE のグローバル6大法域における法定配合基準 (Layer 1) は？
- 6大法域規制ステータス — 日本(JP): none、韓国(KR): none、欧州(EU): none、米国(US): none、中国(CN): allowed、ASEAN: none。
- Q3. 処方設計における ETHYLHEXYL PALMITATE の通常配合濃度 (Layer 3) と適正 pH は？
- 主要剤形 (aqueous_serum) において通常 3〜15%（中央値 11.35%）で配合され、適正pH範囲は 4〜8 です。
- Q4. ETHYLHEXYL PALMITATE の配合禁忌 (Incompatibilities) と推奨シナジー成分は？
- 推奨シナジーペアは GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL、配合上の注意点は Verify phase compatibility under extreme pH or high electrolyte loads です。