# XANTHAN GUM (xanthan-gum) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/xanthan-gum - **Standard INCI**: `XANTHAN GUM` - **KR MFDS Standard Name**: `잔탄검` - **CAS No.**: `11138-66-2` - **EC / EINECS No.**: `234-394-2` - **Origin**: `ferment` - **Functions**: 피부컨디셔닝제, 결합제, 유화제, 유화안정제, 겔형성제, 세정제, 점도조절제 - **Molecular Formula / MW**: `(C35H49O29)n` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 잔탄검 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | XANTHAN GUM | | US (PCPC / MoCRA INCI) | XANTHAN GUM | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 黄原胶 | | JP (JCIA / MHLW QD) | キサンタンガム (QD: キサンタンガム) | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `3086`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - **cn_iecic_max** (leave_on): ≤ 3% — NMPA IECIC (2025) Entry 02960 (2025) - **cn_iecic_max** (rinse_off): ≤ 3% — NMPA IECIC (2025) Entry 02960 (2025) ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 2 – 12 - **Max Process Temp**: ≤ 85°C - **Synergy Pairings**: SCLEROTIUM GUM, GLYCERIN, BUTYLENE GLYCOL, PROPANEDIOL, CARBOMER - **Incompatibilities**: Forms unhydrated lumps ('fish-eyes') if added directly to water without polyol pre-dispersion; Causes slimy stringiness and pilling if used alone > 0.35% ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: XANTHAN GUM | CAS No.: 11138-66-2 | EC No.: 234-394-2 - Origin: FERMENT | Functions: Skin Conditioning, , , , , , - Physicochemical Profile: Formula (C35H49O29)n | MW /(Polymer/Complex) | / | Ionic Nature: anionic | PubChem CID 7107 - Official Regional Label Names: US [XANTHAN GUM] · EU [XANTHAN GUM] · CN [黄原胶] · JP [キサンタンガム] · JP Quasi-Drug [キサンタンガム] ■ [2. Dermatological Mechanism of Action & Functional Role] - Xanthan gum Classified under origin 'ferment', it acts within the cosmetic vehicle or stratum corneum to deliver , , , , , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3086 (黄原胶)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 3.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 3.0% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.05 ~ 1.0% (Median 0.2%, Ref: Fufeng Xanthan Gum 80Mesh TDS & CIR Assessment) — Aqueous suspension stabilizer & co-thickener - [emulsion_cream] Typical range: 0.05 ~ 0.8% (Median 0.2%, Ref: Fufeng Xanthan Gum TDS & CIR Reported Use) — Emulsion thermal stabilizer & pseudoplastic modifier - [cleanser_rinse] Typical range: 0.1 ~ 1.5% (Median 0.45%, Ref: CIR Microbial Polysaccharide Gums Assessment) — Sulfate-free cleanser thickener & foam stabilizer ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase (Pre-wet 1:3 in Glycerin or Butylene Glycol before water addition) - Optimal pH Range: pH 2.0 ~ 12.0 | Max Process Temp: Max 85°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Forms unhydrated lumps ('fish-eyes') if added directly to water without polyol pre-dispersion - Incompatibility / Caution: Causes slimy stringiness and pilling if used alone > 0.35% - Synergy Pairings: SCLEROTIUM GUM, GLYCERIN, BUTYLENE GLYCOL, PROPANEDIOL, CARBOMER | Reference Trade Names: Keltrol® CG-T, FUFENG® Xanthan 80, Rhodicare® T ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 42238324 (2026, Int J Pharm X): Synthesis of a temperature responsive semi-inter-penetrating polymer network of poly (diethyl acrylamide)-xanthan gum en - PMID 42190786 (2026, Int J Biol Macromol): Impact of cationic, anionic, and amphiphilic emulsifiers on the physicochemical properties and applications of xanthan g - PMID 42144152 (2026, Int J Biol Macromol): Sodium hyaluronate-based hydrogels with enhanced mechanical properties and anti-oxidant and anti-inflammatory characteri ## 6. Linked PubMed Literature - [PMID: 42238324] Synthesis of a temperature responsive semi-inter-penetrating polymer network of poly (diethyl acrylamide)-xanthan gum enriched with umbilical cord blood serum for wound healing — *Int J Pharm X* (2026) - [PMID: 42190786] Impact of cationic, anionic, and amphiphilic emulsifiers on the physicochemical properties and applications of xanthan gum-shea butter bigels — *Int J Biol Macromol* (2026) - [PMID: 42144152] Sodium hyaluronate-based hydrogels with enhanced mechanical properties and anti-oxidant and anti-inflammatory characteristics for wound healing — *Int J Biol Macromol* (2026) - [PMID: 42000150] Antibacterial properties of sweeping-frequency ultrasonic modified xanthan gum@ZnO composite film and application in grape preservation — *Food Chem* (2026) - [PMID: 41863097] Efficacy of Xanthan-Based Chlorhexidine Gel in Peri-Implant Mucositis Treatment: A Split-Mouth Randomized Clinical Trial — *Clin Implant Dent Relat Res* (2026) - [PMID: 41750539] Formulation and Biological Evaluation of Glycyrrhiza glabra L. Methanolic Extract: An Exploratory Study in the Context of Rosacea — *Antioxidants (Basel)* (2026) - [PMID: 41745037] A Natural Antioxidant-Rich Hydrogel Formulation with Laurus nobilis Hydrosol: Physicochemical and Cosmeceutical Evaluation — *Gels* (2026) - [PMID: 41696338] Unveiling Supramolecular Structures Formed by Menthol and Xanthan Gum in Oleic Acid-Based Microemulsions — *ACS Omega* (2026) - [PMID: 41619600] Poly-5-aminoindole:Poly(4-styrenesulfonic acid) loaded locust bean gum/xanthan gum hydrogel for transdermal delivery of Imatinib via iontophoresis — *Biomater Adv* (2026) - [PMID: 41508856] Dermal gel formulation of Guiera senegalensis (sabara) leaf extract: development, characterisation, and antibacterial evaluation — *Drug Dev Ind Pharm* (2026) - [PMID: 42126343] Liquid Metal Reinforced Double-Network Hydrogels for Flexible and Stretchable Strain Sensors — *Langmuir* (2026) - [PMID: 42072063] Grape Pomace Extract-Loaded Liposomes Enriched Cream Formulations for Skincare — *Antioxidants (Basel)* (2026)