# TRIETHANOLAMINE (triethanolamine) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/triethanolamine
- **Standard INCI**: `TRIETHANOLAMINE`
- **KR MFDS Standard Name**: `트라이에탄올아민`
- **CAS No.**: `102-71-6`
- **EC / EINECS No.**: `203-049-8`
- **Origin**: `synthetic`
- **Functions**: pH조절제, 향료, 완충제, 유화제, 세정제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 트라이에탄올아민 |
| KR (Former Names) | 트리에탄올아민 |
| EU (CosIng 1223/2009) | TRIETHANOLAMINE |
| US (PCPC / MoCRA INCI) | TRIETHANOLAMINE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 三乙醇胺 |
| JP (JCIA / MHLW QD) | TRIETHANOLAMINE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `restricted`
- **EU (1223/2009)**: `restricted`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `5819`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`

- **KR** [limited]: ≤ 2.5% —  (화장품 사용제한 원료 정보 (식약처 오픈API · 안전기준 [별표2]))
- **EU** [limited]: ≤ 2.5% —  (Regulation (EC) No 1223/2009 Annex III — via CosIng (EU Commission))

## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: TRIETHANOLAMINE | CAS No.: 102-71-6 | EC No.: 203-049-8
  - Origin: SYNTHETIC | Functions: pH, , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [TRIETHANOLAMINE] · EU [TRIETHANOLAMINE] · CN [三乙醇胺] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - TRIETHANOLAMINE functions primarily as pH, , , ,  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver pH, , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 5819 (三乙醇胺))
  - [KR / COMPOSITION / limited] (Max 2.5%): 
  - [EU / COMPOSITION / limited] (Max 2.5%): 
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.1 ~ 1.0% (Median 0.3%, Ref: Global Starter Formulation Library Statistical Distribution (n=14, GRANT 11 · SEPPIC 3)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [emulsion_cream] Typical range: 0.07 ~ 1.5% (Median 0.2%, Ref: Global Starter Formulation Library Statistical Distribution (n=23, GRANT 18 · SEPPIC 5)) — Emulsion cream & lotion structural / conditioning agent
  - [sun_color] Typical range: 0.1 ~ 2.0% (Median 0.35%, Ref: Global Starter Formulation Library Statistical Distribution (n=8, GRANT 7 · SEPPIC 1)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: TRIETHANOLAMINE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 42289089 (2026, Adv Skin Wound Care): Effectiveness of Trolamine in Preventing Radiotherapy-Related Skin Toxicity in Breast Cancer: A Meta-Analysis and Trial 
  - PMID 41275914 (2025, J Pharm Sci): Development and characterization of low molecular weight heparin-triethanolamine cream: Skin permeability and antithromb
  - PMID 39408888 (2024, Int J Mol Sci): Preparation, Characterization, and Wound Healing Promotion of Hydrogels Containing Glucosyloxybenzyl 2-Isobutylmalates E

## 6. Linked PubMed Literature
- [PMID: 42289089] Effectiveness of Trolamine in Preventing Radiotherapy-Related Skin Toxicity in Breast Cancer: A Meta-Analysis and Trial Sequential Analysis Study of Randomized Controlled Trials — *Adv Skin Wound Care* (2026)
- [PMID: 41275914] Development and characterization of low molecular weight heparin-triethanolamine cream: Skin permeability and antithrombotic efficacy — *J Pharm Sci* (2025)
- [PMID: 39408888] Preparation, Characterization, and Wound Healing Promotion of Hydrogels Containing Glucosyloxybenzyl 2-Isobutylmalates Extract from Bletilla striata (Thunb.) Reichb.f — *Int J Mol Sci* (2024)
- [PMID: 42283162] Enhancing Biological Activity in Skin Repair with a Transdermal Peptide-Recombinant Type III Collagen Hydrogel — *Curr Protoc* (2026)
- [PMID: 42163615] Design of Antiacne Gel Containing Phloretin — *Antiinflamm Antiallergy Agents Med Chem* (2026)
- [PMID: 41449306] Preparation of Tanshinone IIA and glycyrrhetinic acid emulsion and preliminary study on its anti-psoriasis efficacy — *Drug Deliv Transl Res* (2026)
- [PMID: 41405844] Panaxadiol saponins-loaded gel for periodontitis therapy: anti-inflammatory and microbiota-modulating effects — *Drug Dev Ind Pharm* (2026)
- [PMID: 41252403] Antitumor and cytotoxic activities of endophytic Enterobacter hormaechei derived secondary metabolites: In-vitro and In-silico study — *PLoS One* (2025)
- [PMID: 41137333] Retrospective analysis of comprehensive nursing care management in pyoderma gangrenosum: Case series and literature review — *Medicine (Baltimore)* (2025)
- [PMID: 40421750] Topical Miconazole Nanogel: In Vitro Characterization, In Vivo Skin Irritation, and Enhanced Antifungal Efficacy — *Drug Dev Res* (2025)
- [PMID: 39821851] A comparative study of human amniotic membrane, tilapia skin collagen, and Centella asiatica derived gel to treat burn wound in rat model — *Cell Tissue Bank* (2025)
- [PMID: 38841970] Clinical profile and photocontact sensitivity pattern in patients with cosmetic dermatitis: A prospective study — *Indian J Dermatol Venereol Leprol* (2024)