# TOCOPHERYL ACETATE (tocopheryl-acetate) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/tocopheryl-acetate - **Standard INCI**: `TOCOPHERYL ACETATE` - **KR MFDS Standard Name**: `토코페릴아세테이트` - **CAS No.**: `7695-91-2` - **EC / EINECS No.**: `231-710-0` - **Origin**: `vitamin` - **Functions**: 항산화제, 피부컨디셔닝제 - **Molecular Formula / MW**: `—` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 토코페릴아세테이트 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | TOCOPHERYL ACETATE | | US (PCPC / MoCRA INCI) | TOCOPHERYL ACETATE | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 生育酚乙酸酯 | | JP (JCIA / MHLW QD) | 酢酸トコフェロール (QD: 酢酸ｄｌ－α－トコフェロール) | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `6043`) - **JP (MHLW)**: `restricted` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - **cn_iecic_max** (leave_on): ≤ 36% — NMPA IECIC (2025) Entry 05895 (2025) - **cn_iecic_max** (rinse_off): ≤ 5% — NMPA IECIC (2025) Entry 05895 (2025) ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4 – 8 - **Max Process Temp**: ≤ 50°C - **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL - **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: TOCOPHERYL ACETATE | CAS No.: 7695-91-2 | EC No.: 231-710-0 - Origin: VITAMIN | Functions: , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [TOCOPHERYL ACETATE] · EU [TOCOPHERYL ACETATE] · CN [生育酚乙酸酯] · JP [酢酸トコフェロール] · JP Quasi-Drug [酢酸ｄｌ－α－トコフェロール] ■ [2. Dermatological Mechanism of Action & Functional Role] - TOCOPHERYL ACETATE functions primarily as , in dermatological and cosmetic formulations. Classified under origin 'vitamin', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: RESTRICTED | ASEAN: NONE (CN IECIC (2025) Entry No. 6043 (生育酚乙酸酯)) - [JP / COMPOSITION / limited] (Max 3.03%): - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 36.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 5.0% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [anhydrous_balm] Typical range: 0.1 ~ 1.0% (Median 0.5%, Ref: Global Starter Formulation Library Statistical Distribution (n=8, EVONIK 4 · GRANT 4)) — Anhydrous balm, oil & stick structural emollient - [aqueous_serum] Typical range: 0.1 ~ 1.0% (Median 0.2%, Ref: Global Starter Formulation Library Statistical Distribution (n=15, GRANT 13 · SEPPIC 2)) — Aqueous serum, toner & hydrogel matrix formulation component - [cleanser_rinse] Typical range: 0.1 ~ 0.35% (Median 0.2%, Ref: Global Starter Formulation Library Statistical Distribution (n=9, GRANT 5 · EVONIK 3 · SEPPIC 1)) — Rinse-off cleanser & surfactant system modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: TOCOPHERYL ACETATE ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 12537931 (2002, Int J Toxicol): Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Olea - PMID 5723132 (1968, J Vitaminol (Kyoto)): Percutaneous absorption of alpha-tocopheryl acetate - PMID 8506388 (1993, Photochem Photobiol): Uptake and bioconversion of alpha-tocopheryl acetate to alpha-tocopherol in skin of hairless mice ## 6. Linked PubMed Literature - [PMID: 12537931] Final report on the safety assessment of Tocopherol, Tocopheryl Acetate, Tocopheryl Linoleate, Tocopheryl Linoleate/Oleate, Tocopheryl Nicotinate, Tocopheryl Succinate, Dioleyl Tocopheryl Methylsilanol, Potassium Ascorbyl Tocopheryl Phosphate, and Tocophersolan — *Int J Toxicol* (2002) - [PMID: 5723132] Percutaneous absorption of alpha-tocopheryl acetate — *J Vitaminol (Kyoto)* (1968) - [PMID: 8506388] Uptake and bioconversion of alpha-tocopheryl acetate to alpha-tocopherol in skin of hairless mice — *Photochem Photobiol* (1993) - [PMID: 41981221] TPGS Modified Phospholipid-free and Cholesterol-free Ethosomes Enhance Chemical Stability and Transdermal Permeation Of Retinol — *AAPS PharmSciTech* (2026) - [PMID: 41309687] Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy — *Sci Rep* (2025) - [PMID: 40196947] Effects of a Moisturizer Containing Colloidal Oatmeal and Filaggrin Technology on Staphylococcus Species In Vitro — *J Drugs Dermatol* (2025) - [PMID: 39330197] Unraveling the Impact of the Oil Phase on the Physicochemical Stability and Skin Permeability of Melatonin Gel Formulations — *Gels* (2024) - [PMID: 37539504] Topical treatment of anal condylomata with Propionibacterium acnes lysate: results of a multicentric observational study — *Ital J Dermatol Venerol* (2023) - [PMID: 34471722] Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial — *Contemp Clin Trials Commun* (2021) - [PMID: 24004959] Tocopheryl acetate 20% spray for elimination of head louse infestation: a randomised controlled trial comparing with 1% permethrin creme rinse — *BMC Pharmacol Toxicol* (2013) - [PMID: 4996747] Isomers of alpha-tocopheryl acetate and their biological activity — *Lipids* (1971) - [PMID: 4999545] Isomers of alpha-tocopheryl acetate and their biological activity — *Lipids* (1971) - [PMID: 1429281] Effect of long- or short-term feeding of alpha-tocopheryl acetate to Holstein and crossbred beef steers on performance, carcass characteristics, and beef color stability — *J Anim Sci* (1992) - [PMID: 40631809] Efficacy of a topical polyphenol-based formulation in palmoplantar psoriasis: an observational study — *Dermatol Reports* (2026) - [PMID: 38556283] Topical Nanoemulsion Hydrogel Formulated from Supercritical Fluid Extracted Palm-Pressed Fiber Oil and Virgin Coconut Oil with Antioxidant and Antibacterial Effects — *J Oleo Sci* (2024) - [PMID: 37153953] Failure of head lice treatment with tocopheryl acetate spray: results of a sponsor-free clinical study — *Ital J Dermatol Venerol* (2023) - [PMID: 35437850] Darier disease successfully treated with a topical agent containing vitamin A (retinyl palmitate), vitamin E, and urea — *J Dermatol* (2022) - [PMID: 34900006] Assessment of a feed additive consisting of all-rac-alpha-tocopheryl acetate (vitamin E) for all animal species for the renewal of its authorisation (Jilin Beisha Pharmaceutical Co., Ltd) — *EFSA J* (2021) - [PMID: 34884343] A Clinical Study on the Efficacy and Tolerability of a New Topical Gel and Toothpaste in Patients with Xerostomia: A Randomized Controlled Trial — *J Clin Med* (2021)