# SODIUM LAURETH SULFATE (sodium-laureth-sulfate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/sodium-laureth-sulfate
- **Standard INCI**: `SODIUM LAURETH SULFATE`
- **KR MFDS Standard Name**: `소듐라우레스설페이트`
- **CAS No.**: `3088-31-1`
- **EC / EINECS No.**: `221-416-0`
- **Origin**: `synthetic`
- **Functions**: 세정제, 유화제, 기포형성제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 소듐라우레스설페이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | SODIUM LAURETH SULFATE |
| US (PCPC / MoCRA INCI) | SODIUM LAURETH SULFATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 月桂醇聚醚硫酸酯钠 |
| JP (JCIA / MHLW QD) | SODIUM LAURETH SULFATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8336`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: SODIUM LAURETH SULFATE | CAS No.: 3088-31-1 | EC No.: 221-416-0
  - Origin: SYNTHETIC | Functions: , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [SODIUM LAURETH SULFATE] · EU [SODIUM LAURETH SULFATE] · CN [月桂醇聚醚硫酸酯钠] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Sodium Laureth Sulfate is the sodium salt of sulfated ethoxylated lauryl alcohol that conforms generally to the formula Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8336 (月桂醇聚醚硫酸酯钠))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [cleanser_rinse] Typical range: 16.0 ~ 45.0% (Median 20.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, GRANT 3 · SEPPIC 2)) — Rinse-off cleanser & surfactant system modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: SODIUM LAURETH SULFATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 41025266 (2025, J Phys Chem B): Can Electrostatic Solvation Entropy Predict Skin Irritation Potential from Surfactants?
  - PMID 40333845 (2025, Molecules): Cleansing Mechanisms and Efficacy on Artificial Skin
  - PMID 39528143 (2024, Int J Pharm): Optimizing ex vivo penetration tests via quantitative confocal Raman spectroscopy: Impact of incubation time, skin hydra

## 6. Linked PubMed Literature
- [PMID: 41025266] Can Electrostatic Solvation Entropy Predict Skin Irritation Potential from Surfactants? — *J Phys Chem B* (2025)
- [PMID: 40333845] Cleansing Mechanisms and Efficacy on Artificial Skin — *Molecules* (2025)
- [PMID: 39528143] Optimizing ex vivo penetration tests via quantitative confocal Raman spectroscopy: Impact of incubation time, skin hydration, surfactant treatment and UVA irradiation on caffeine distribution — *Int J Pharm* (2024)
- [PMID: 35805241] Skin Toxicity of Selected Hair Cosmetic Ingredients: A Review Focusing on Hairdressers — *Int J Environ Res Public Health* (2022)
- [PMID: 34608651] High-performance sulphate-free cleansers: Surface activity, foaming and rheology — *Int J Cosmet Sci* (2021)
- [PMID: 34577098] Soapwort (Saponaria officinalis L.) Extract vs. Synthetic Surfactants-Effect on Skin-Mimetic Models — *Molecules* (2021)
- [PMID: 34063161] Determination of SLES in Personal Care Products by Colloid Titration with Light Reflection Measurements — *Molecules* (2021)
- [PMID: 41685624] Preservative Kinetics and Influence of Surfactants on Gram-Negative Bacterial Membrane Partitioning — *Langmuir* (2026)
- [PMID: 41304500] From Safety Evaluation to Influencing Factors Analysis: A Comprehensive Investigation on Ocular Irritation of Baby Bath Products — *Toxics* (2025)
- [PMID: 38750817] Comprehensive rheological analysis of structurally related acetan-like heteroexopolysaccharides from two Kozakia baliensis strains in surfactants and galactomannan blends — *N Biotechnol* (2024)
- [PMID: 38705867] Synthesis and Performance of Bio-Based Amphoteric Surfactants — *Chemistry* (2024)
- [PMID: 34343783] Precursor ion approach for simultaneous determination of nonethoxylated and ethoxylated alkylsulfate surfactants — *J Chromatogr A* (2021)