# SODIUM LACTATE (sodium-lactate) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/sodium-lactate - **Standard INCI**: `SODIUM LACTATE` - **KR MFDS Standard Name**: `소듐락테이트` - **CAS No.**: `72-17-3` - **EC / EINECS No.**: `200-772-0` - **Origin**: `synthetic` - **Functions**: pH조절제, 보습제, 완충제, 각질제거제 - **Molecular Formula / MW**: `—` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 소듐락테이트 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | SODIUM LACTATE | | US (PCPC / MoCRA INCI) | SODIUM LACTATE | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 乳酸钠 | | JP (JCIA / MHLW QD) | SODIUM LACTATE | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `5686`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - Listed within general cosmetic GMP safety thresholds. ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4 – 8 - **Max Process Temp**: ≤ 50°C - **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL - **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: SODIUM LACTATE | CAS No.: 72-17-3 | EC No.: 200-772-0 - Origin: SYNTHETIC | Functions: pH, , , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [SODIUM LACTATE] · EU [SODIUM LACTATE] · CN [乳酸钠] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - SODIUM LACTATE functions primarily as pH, , , in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver pH, , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 5686 (乳酸钠)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [cleanser_rinse] Typical range: 2.5 ~ 10.0% (Median 3.7%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 5)) — Rinse-off cleanser & surfactant system modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: SODIUM LACTATE ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 42289724 (2026, Epigenetics Chromatin): Role of LDHA in senescent fibroblast exosomes promoting ferroptosis via histone lactylation-mediated ACSL4 regulation in - PMID 42191694 (2026, Nat Commun): Skin-mimicking biogel-based iontronic sensor with hierarchical bionic coupling for dexterous tactile e-skin - PMID 42109031 (2026, Eur J Anaesthesiol): Clinical effectiveness of intravenous hypertonic sodium lactate infusion for intra-operative brain relaxation in suprate ## 6. Linked PubMed Literature - [PMID: 42289724] Role of LDHA in senescent fibroblast exosomes promoting ferroptosis via histone lactylation-mediated ACSL4 regulation in skin photoaging — *Epigenetics Chromatin* (2026) - [PMID: 42191694] Skin-mimicking biogel-based iontronic sensor with hierarchical bionic coupling for dexterous tactile e-skin — *Nat Commun* (2026) - [PMID: 42109031] Clinical effectiveness of intravenous hypertonic sodium lactate infusion for intra-operative brain relaxation in supratentorial brain tumour surgery: A double-blind randomised phase II pilot study — *Eur J Anaesthesiol* (2026) - [PMID: 42054076] Lactate conditioning reprograms mucosal-associated invariant T cell metabolism boosting effector function — *J Immunol* (2026) - [PMID: 41417686] Lactate modulates TGF-β1- and IL-1β-induced transcriptional programs in human dermal fibroblasts: Potential implications for wound management — *J Trauma Acute Care Surg* (2026) - [PMID: 41059623] Time-Resolved Sweat Collection for Off-Body SERS Analysis: Bridging Wearability and Sensitivity — *ACS Sens* (2025) - [PMID: 39675633] Development of Antimicrobial Biopolymer Film Incorporated with a Mixture of Sodium Lactate and Diacetate and Studying its Efficacy Against Listeria monocytogenes and Microbiological Spoilage in Deli Meat Over 12 Weeks of Storage — *J Food Prot* (2025) - [PMID: 36221362] Clinical effectiveness of hypertonic sodium lactate infusion for intraoperative brain relaxation in patients undergoing scheduled craniotomy for supratentorial brain tumor resection: A study protocol of a single center double-blind randomized controlled phase II pilot trial — *Medicine (Baltimore)* (2022) - [PMID: 38051949] Sweat Sensor Based on Wearable Janus Textiles for Sweat Collection and Microstructured Optical Fiber for Surface-Enhanced Raman Scattering Analysis — *ACS Sens* (2023) - [PMID: 36278667] Application of the Composite Fibers Based on Chitosan and Chitin Nanofibrils in Cosmetology — *J Funct Biomater* (2022) - [PMID: 33542142] Developing a multimodal biosensor for remote physiological monitoring — *BMJ Mil Health* (2023) - [PMID: 30237745] In vitro study of RRS® Silisorg CE Class III medical device composed of silanol: effect on human skin fibroblasts and its clinical use — *Med Devices (Auckl)* (2018)