# SODIUM COCOYL ISETHIONATE (sodium-cocoyl-isethionate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/sodium-cocoyl-isethionate
- **Standard INCI**: `SODIUM COCOYL ISETHIONATE`
- **KR MFDS Standard Name**: `소듐코코일이세티오네이트`
- **CAS No.**: `61789-32-0`
- **EC / EINECS No.**: `263-052-5`
- **Origin**: `synthetic`
- **Functions**: 세정제, 모발컨디셔닝제
- **Molecular Formula / MW**: `C14H27NaO5S` (364.43 g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 소듐코코일이세티오네이트 |
| KR (Former Names) | 소듐코코일이세치오네이트 |
| EU (CosIng 1223/2009) | SODIUM COCOYL ISETHIONATE |
| US (PCPC / MoCRA INCI) | SODIUM COCOYL ISETHIONATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 椰油酰羟乙磺酸酯钠 |
| JP (JCIA / MHLW QD) | SODIUM COCOYL ISETHIONATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `7587`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 1% — NMPA IECIC (2025) Entry 07615 (2025)
- **cn_iecic_max** (rinse_off): ≤ 35% — NMPA IECIC (2025) Entry 07615 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 5 – 7
- **Max Process Temp**: ≤ 85°C
- **Synergy Pairings**: COCAMIDOPROPYL BETAINE, COCO-GLUCOSIDE, GLYCERIN, STEARIC ACID
- **Incompatibilities**: Limited cold-water solubility creates creamy pearlescent pastes; keep pH between 5.0~7.0 to prevent ester hydrolysis

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: SODIUM COCOYL ISETHIONATE | CAS No.: 61789-32-0 | EC No.: 263-052-5
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula C14H27NaO5S | MW 364.43 g/mol | /   | Ionic Nature: anionic | PubChem CID 23665768
  - Official Regional Label Names: US [SODIUM COCOYL ISETHIONATE] · EU [SODIUM COCOYL ISETHIONATE] · CN [椰油酰羟乙磺酸酯钠] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Fatty acids, coco, 2-sulfoethyl esters, sodium salts Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 7587 (椰油酰羟乙磺酸酯钠))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 1.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 35.0%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [cleanser_rinse] Typical range: 2.0 ~ 35.0% (Median 10.0%, Ref: BASF Jordapon CI / Innospec Pureact I-78 TDS & CIR) — Sulfate-free mild creamy cleansing foam & syndet primary surfactant
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Surfactant Phase (Heat to 75~80°C with Coco-Glucoside/Betaine to dissolve noodles/powder)
  - Optimal pH Range: pH 5.0 ~ 7.0 | Max Process Temp: Max 85°C | Electrolyte Tolerance: HIGH
  - Incompatibility / Caution: Limited cold-water solubility creates creamy pearlescent pastes; keep pH between 5.0~7.0 to prevent ester hydrolysis
  - Synergy Pairings: COCAMIDOPROPYL BETAINE, COCO-GLUCOSIDE, GLYCERIN, STEARIC ACID | Reference Trade Names: Jordapon® CI, Elfan® AT 84, Hostapon® SCI
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 40905482 (2026, Int J Cosmet Sci): Influence of anionic surfactants on coacervation with cationic guar gum for hair care applications
  - PMID 18818848 (2008, J Cosmet Sci): Visualization and quantification of skin barrier perturbation induced by surfactant-humectant systems using two-photon f
  - PMID 17598025 (2007, J Cosmet Sci): Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes

## 6. Linked PubMed Literature
- [PMID: 40905482] Influence of anionic surfactants on coacervation with cationic guar gum for hair care applications — *Int J Cosmet Sci* (2026)
- [PMID: 18818848] Visualization and quantification of skin barrier perturbation induced by surfactant-humectant systems using two-photon fluorescence microscopy — *J Cosmet Sci* (2008)
- [PMID: 17598025] Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores — *J Cosmet Sci* (2007)
- [PMID: 10385334] Irritancy ranking of anionic detergents using one-time occlusive, repeated occlusive and repeated open tests — *Contact Dermatitis* (1999)
- [PMID: 10048655] Biophysical characterization of skin damage and recovery after exposure to different surfactants — *Contact Dermatitis* (1999)
- [PMID: 27333375] Irritancy testing of sodium laurate and other anionic detergents using an open exposure model — *Skin Res Technol* (1997)
- [PMID: 19272112] In-use tolerability of two new syndet bars with sodium cocoyl isethionate, disodium lauryl sulfosuccinate and wheat starch as major ingredients in differing relations: results of a cross-over trial — *Int J Cosmet Sci* (1992)
- [PMID: 14730372] Solubilization of sodium cocoyl isethionate — *J Cosmet Sci* (2003)