# PROPYLENE GLYCOL (propylene-glycol) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/propylene-glycol - **Standard INCI**: `PROPYLENE GLYCOL` - **KR MFDS Standard Name**: `프로필렌글라이콜` - **CAS No.**: `57-55-6` - **EC / EINECS No.**: `200-338-0` - **Origin**: `synthetic` - **Functions**: 향료, 보습제, 용제, 점도조절제, 피부컨디셔닝제 - **Molecular Formula / MW**: `—` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 프로필렌글라이콜 | | KR (Former Names) | 프로필렌글리콜 | | EU (CosIng 1223/2009) | PROPYLENE GLYCOL | | US (PCPC / MoCRA INCI) | PROPYLENE GLYCOL | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 丙二醇 | | JP (JCIA / MHLW QD) | PROPYLENE GLYCOL | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `1383`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - Listed within general cosmetic GMP safety thresholds. ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4 – 8 - **Max Process Temp**: ≤ 50°C - **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL - **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: PROPYLENE GLYCOL | CAS No.: 57-55-6 | EC No.: 200-338-0 - Origin: SYNTHETIC | Functions: , , , , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [PROPYLENE GLYCOL] · EU [PROPYLENE GLYCOL] · CN [丙二醇] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Propylene Glycol is the aliphatic alcohol that conforms generally to the formula Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 1383 (丙二醇)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [anhydrous_balm] Typical range: 0.2 ~ 23.0% (Median 4.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, ELEMENTIS 4 · EVONIK 1)) — Anhydrous balm, oil & stick structural emollient - [aqueous_serum] Typical range: 0.1 ~ 49.5% (Median 3.5%, Ref: Global Starter Formulation Library Statistical Distribution (n=16, EVONIK 10 · SEPPIC 3 · ELEMENTIS 2 · GRANT 1)) — Aqueous serum, toner & hydrogel matrix formulation component - [cleanser_rinse] Typical range: 1.0 ~ 23.0% (Median 2.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=12, EVONIK 11 · SEPPIC 1)) — Rinse-off cleanser & surfactant system modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: PROPYLENE GLYCOL ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 42320812 (2026, Int J Biol Macromol): Hypromellose functionality in film-forming solutions: In vitro characterization and in silico optimization for topical a - PMID 42283162 (2026, Curr Protoc): Enhancing Biological Activity in Skin Repair with a Transdermal Peptide-Recombinant Type III Collagen Hydrogel - PMID 42271005 (2026, Sci Rep): Preparation, characterization and in-vivo evaluation of nanoemulsion based hydrogel of ferulic acid in imiquimod-induced ## 6. Linked PubMed Literature - [PMID: 42320812] Hypromellose functionality in film-forming solutions: In vitro characterization and in silico optimization for topical administration of ketoprofen — *Int J Biol Macromol* (2026) - [PMID: 42283162] Enhancing Biological Activity in Skin Repair with a Transdermal Peptide-Recombinant Type III Collagen Hydrogel — *Curr Protoc* (2026) - [PMID: 42271005] Preparation, characterization and in-vivo evaluation of nanoemulsion based hydrogel of ferulic acid in imiquimod-induced psoriasis in rats — *Sci Rep* (2026) - [PMID: 42223998] "Rutin-Loaded Film-Forming Spray for Accelerated Wound Repair: A QbD-Guided Translational Approach" — *Pharm Dev Technol* (2026) - [PMID: 42202650] DES-mediated self-assembled polypeptides: Synergistic neuromuscular signaling inhibition for anti-aging — *Biomater Adv* (2026) - [PMID: 42184966] Tapinarof as a Likely Contact Allergen: Evidence From Patch Testing of Allergic and Irritant Contact Dermatitis — *Contact Dermatitis* (2026) - [PMID: 42173383] Impact of porcine skin processing on in vitro permeation testing: implications for reliable evaluation of topical metformin delivery — *Eur J Pharm Sci* (2026) - [PMID: 42163615] Design of Antiacne Gel Containing Phloretin — *Antiinflamm Antiallergy Agents Med Chem* (2026) - [PMID: 42136529] Seta-Inspired Mechano-Intelligent Janus Bandage with Coordinated Adhesion-Contraction for Minimizing Scarring — *Adv Mater* (2026) - [PMID: 42266070] Short-Chain Diol Effects on the Self-Assembly of Polyoxyethylene Oleyl Ethers in Dilute Aqueous Solutions and Their Cosmetic Applications — *J Phys Chem B* (2026) - [PMID: 42197133] Valorization of Aromatic Plant Distillation Residues: Phenolic Composition, Antioxidant Capacity, and Antimicrobial Activity of Rhododendron tomentosum Harmaja Extracts — *Molecules* (2026) - [PMID: 42072063] Grape Pomace Extract-Loaded Liposomes Enriched Cream Formulations for Skincare — *Antioxidants (Basel)* (2026)