# POLYQUATERNIUM-10 (polyquaternium-10) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/polyquaternium-10
- **Standard INCI**: `POLYQUATERNIUM-10`
- **KR MFDS Standard Name**: `폴리쿼터늄-10`
- **CAS No.**: `81859-24-7`
- **EC / EINECS No.**: `617-262-2`
- **Origin**: `synthetic`
- **Functions**: 대전방지제, 필름형성제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 폴리쿼터늄-10 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | POLYQUATERNIUM-10 |
| US (PCPC / MoCRA INCI) | POLYQUATERNIUM-10 |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 聚季铵盐-10 |
| JP (JCIA / MHLW QD) | POLYQUATERNIUM-10  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3906`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: POLYQUATERNIUM-10 | CAS No.: 81859-24-7 | EC No.: 617-262-2
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [POLYQUATERNIUM-10] · EU [POLYQUATERNIUM-10] · CN [聚季铵盐-10] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Cellulose, 2-(2-hydroxy-3-(trimethylammonium)propoxy)ethyl ether, chloride;
Cellulose, 2-hydroxyethyl 2-[2-hydroxy-3-(trimethylammonio)propoxy]ethyl 2-hydroxy-3-(trimethylammonio)propyl ether, chloride 
Cellulose, ether with alpha-[2-hydroxy-3-(trimethylammonio)propyl]-omega-hydroxypoly(oxy-1,2-ethanediyl), chloride Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3906 (聚季铵盐-10))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [cleanser_rinse] Typical range: 0.2 ~ 0.6% (Median 0.25%, Ref: Global Starter Formulation Library Statistical Distribution (n=19, EVONIK 17 · ELEMENTIS 1 · SEPPIC 1)) — Rinse-off cleanser & surfactant system modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: POLYQUATERNIUM-10
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 25631258 (2015, J Mater Sci Mater Med): Ocular biocompatibility of polyquaternium 10 gel: functional and morphological results.
  - PMID 28018490 (2016, Anal Methods): Detecting Levels of Polyquaternium-10 (PQ-10) via Potentiometric Titration with Dextran Sulphate and Monitoring the Equi
  - PMID 39322171 (2024, Int J Biol Macromol): Dialdehyde cellulose nanofibrils/polyquaternium stabilized ultra-fine silver nanoparticles for synergistic antibacterial

## 6. Linked PubMed Literature
- [PMID: 25631258] Ocular biocompatibility of polyquaternium 10 gel: functional and morphological results. — *J Mater Sci Mater Med* (2015)
- [PMID: 28018490] Detecting Levels of Polyquaternium-10 (PQ-10) via Potentiometric Titration with Dextran Sulphate and Monitoring the Equivalence Point with a Polymeric Membrane-Based Polyion Sensor. — *Anal Methods* (2016)
- [PMID: 39322171] Dialdehyde cellulose nanofibrils/polyquaternium stabilized ultra-fine silver nanoparticles for synergistic antibacterial therapy. — *Int J Biol Macromol* (2024)