# POLYGLYCERYL-6 STEARATE (polyglyceryl-6-stearate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/polyglyceryl-6-stearate
- **Standard INCI**: `POLYGLYCERYL-6 STEARATE`
- **KR MFDS Standard Name**: `폴리글리세릴-6스테아레이트`
- **CAS No.**: `95461-65-7`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 에모리엔트
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 폴리글리세릴-6스테아레이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | POLYGLYCERYL-6 STEARATE |
| US (PCPC / MoCRA INCI) | POLYGLYCERYL-6 STEARATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 聚甘油-6 硬脂酸酯 |
| JP (JCIA / MHLW QD) | POLYGLYCERYL-6 STEARATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3875`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8.5
- **Max Process Temp**: ≤ 85°C
- **Synergy Pairings**: POLYGLYCERYL-6 BEHENATE, CETEARYL ALCOHOL, GLYCERYL STEARATE
- **Incompatibilities**: Highly resilient to organic acid preservatives and water-soluble UV filters

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: POLYGLYCERYL-6 STEARATE | CAS No.: 95461-65-7 | EC No.: N/A
  - Origin: SYNTHETIC | Functions: 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [POLYGLYCERYL-6 STEARATE] · EU [POLYGLYCERYL-6 STEARATE] · CN [聚甘油-6 硬脂酸酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - ester of hexaglycerol and stearic acid Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3875 (聚甘油-6 硬脂酸酯))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 1.5 ~ 4.0% (Median 2.5%, Ref: Evonik TEGO Care PBS 6 TDS & Formulation Library) — Low-viscosity milky toner & lotion PEG-free O/W emulsifier
  - [sun_color] Typical range: 1.5 ~ 4.0% (Median 2.8%, Ref: Evonik TEGO Care PBS 6 Technical Dossier) — O/W sun-serum & high-UV-load emulsifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Oil Phase (Heat to 75~80°C with Polyglyceryl-6 Behenate)
  - Optimal pH Range: pH 4.0 ~ 8.5 | Max Process Temp: Max 85°C | Electrolyte Tolerance: HIGH
  - Incompatibility / Caution: Highly resilient to organic acid preservatives and water-soluble UV filters
  - Synergy Pairings: POLYGLYCERYL-6 BEHENATE, CETEARYL ALCOHOL, GLYCERYL STEARATE | Reference Trade Names: TEGO® Care PBS 6
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

## 6. Linked PubMed Literature