# POLYGLYCERYL-10 LAURATE (polyglyceryl-10-laurate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/polyglyceryl-10-laurate
- **Standard INCI**: `POLYGLYCERYL-10 LAURATE`
- **KR MFDS Standard Name**: `폴리글리세릴-10라우레이트`
- **CAS No.**: `34406-66-1`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 피부컨디셔닝제, 유화제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 폴리글리세릴-10라우레이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | POLYGLYCERYL-10 LAURATE |
| US (PCPC / MoCRA INCI) | POLYGLYCERYL-10 LAURATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 聚甘油-10 月桂酸酯 |
| JP (JCIA / MHLW QD) | POLYGLYCERYL-10 LAURATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3800`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 6% — NMPA IECIC (2025) Entry 03595 (2025)
- **cn_iecic_max** (rinse_off): ≤ 5% — NMPA IECIC (2025) Entry 03595 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8.5
- **Max Process Temp**: ≤ 80°C
- **Synergy Pairings**: POLYGLYCERYL-4 CAPRATE, 1,2-HEXANEDIOL, BUTYLENE GLYCOL
- **Incompatibilities**: Must pre-mix thoroughly with lipophilic oil/fragrance (3:1 to 5:1 ratio) prior to water addition; otherwise cloudiness occurs

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: POLYGLYCERYL-10 LAURATE | CAS No.: 34406-66-1 | EC No.: N/A
  - Origin: SYNTHETIC | Functions: Skin Conditioning, 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [POLYGLYCERYL-10 LAURATE] · EU [POLYGLYCERYL-10 LAURATE] · CN [聚甘油-10 月桂酸酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Polyglyceryl-10 Laurate is an ester of lauric acid and Polyglycerin-10 Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3800 (聚甘油-10 月桂酸酯))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 6.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 5.0%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.2 ~ 3.0% (Median 0.8%, Ref: Evonik TEGOSOFT PC 41 / Nikkol Decaglyn 1-L TDS & CIR) — PEG-free clear aqueous solubilizer for fragrances and lipophilic actives
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Solubilization Pre-mix (Pre-mix 3:1 to 5:1 with fragrance/essential oil before adding water)
  - Optimal pH Range: pH 4.0 ~ 8.5 | Max Process Temp: Max 80°C | Electrolyte Tolerance: HIGH
  - Incompatibility / Caution: Must pre-mix thoroughly with lipophilic oil/fragrance (3:1 to 5:1 ratio) prior to water addition; otherwise cloudiness occurs
  - Synergy Pairings: POLYGLYCERYL-4 CAPRATE, 1,2-HEXANEDIOL, BUTYLENE GLYCOL | Reference Trade Names: Nikkol Decaglyn 1-L, Polyaldo® 10-1-L
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

## 6. Linked PubMed Literature