# POLYACRYLATE CROSSPOLYMER-6 (polyacrylate-crosspolymer-6) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/polyacrylate-crosspolymer-6
- **Standard INCI**: `POLYACRYLATE CROSSPOLYMER-6`
- **KR MFDS Standard Name**: `폴리아크릴레이트크로스폴리머-6`
- **CAS No.**: `N/A`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 점도조절제, 유화안정제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 폴리아크릴레이트크로스폴리머-6 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | POLYACRYLATE CROSSPOLYMER-6 |
| US (PCPC / MoCRA INCI) | POLYACRYLATE CROSSPOLYMER-6 |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 聚丙烯酸酯交联聚合物-6 |
| JP (JCIA / MHLW QD) | POLYACRYLATE CROSSPOLYMER-6  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3720`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 3% — NMPA IECIC (2025) Entry 03561 (2025)
- **cn_iecic_max** (rinse_off): ≤ 2% — NMPA IECIC (2025) Entry 03561 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 2 – 8
- **Max Process Temp**: ≤ 80°C
- **Synergy Pairings**: HYDROLYZED SPONGE, ASCORBIC ACID, TRANEXAMIC ACID, GLYCOLIC ACID, SALICYLIC ACID
- **Incompatibilities**: Excessive dosage (>1.2% alone) may cause slight stringiness or pilling; blend with 0.05~0.1% Xanthan Gum for optimal break

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: POLYACRYLATE CROSSPOLYMER-6 | CAS No.: N/A | EC No.: N/A
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: anionic | CosIng/MFDS 
  - Official Regional Label Names: US [POLYACRYLATE CROSSPOLYMER-6] · EU [POLYACRYLATE CROSSPOLYMER-6] · CN [聚丙烯酸酯交联聚合物-6] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Polyacrylate Crosspolymer-6 is a copolymer of ammonium acryloyldimethyltaurate, dimethylacrylamide, lauryl methacrylate and laureth-4 methacrylate, crosslinked with trimethylolpropane triacrylate Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3720 (聚丙烯酸酯交联聚合物-6))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 3.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 2.0%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.15 ~ 2.0% (Median 0.6%, Ref: SEPPIC SEPIMAX ZEN Technical Data Sheet & CN IECIC) — Electrolyte-resistant thickener & spicule suspension matrix
  - [emulsion_cream] Typical range: 0.15 ~ 1.5% (Median 0.5%, Ref: SEPPIC SEPIMAX ZEN TDS & CN IECIC) — Low-pH & high-electrolyte emulsion stabilizer
  - [cleanser_rinse] Typical range: 0.1 ~ 3.0% (Median 1.25%, Ref: Global Starter Formulation Library Statistical Distribution (n=10, SEPPIC 10)) — Rinse-off cleanser & surfactant system modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Oil Phase dispersion
  - Optimal pH Range: pH 2.0 ~ 8.0 | Max Process Temp: Max 80°C | Electrolyte Tolerance: HIGH
  - Incompatibility / Caution: Excessive dosage (>1.2% alone) may cause slight stringiness or pilling; blend with 0.05~0.1% Xanthan Gum for optimal break
  - Synergy Pairings: HYDROLYZED SPONGE, ASCORBIC ACID, TRANEXAMIC ACID, GLYCOLIC ACID, SALICYLIC ACID | Reference Trade Names: SEPIMAX™ ZEN
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 41471047 (2025, Pharmaceutics): Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and 

## 6. Linked PubMed Literature
- [PMID: 41471047] Interfacial Molecular Interactions as Determinants of Nanostructural Preservation in Ibuprofen-Loaded Nanoemulsions and Nanoemulsion Gels — *Pharmaceutics* (2025)