# PHYTOSPHINGOSINE (phytosphingosine) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/phytosphingosine
- **Standard INCI**: `PHYTOSPHINGOSINE`
- **KR MFDS Standard Name**: `피토스핑고신`
- **CAS No.**: `554-62-1`
- **EC / EINECS No.**: `N/A`
- **Origin**: `plant`
- **Functions**: 모발컨디셔닝제, 피부컨디셔닝제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 피토스핑고신 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | PHYTOSPHINGOSINE |
| US (PCPC / MoCRA INCI) | PHYTOSPHINGOSINE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 植物鞘氨醇 |
| JP (JCIA / MHLW QD) | フィトスフィンゴシン (QD: フィトスフィンゴシン) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8597`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 1% — NMPA IECIC (2025) Entry 08571 (2025)
- **cn_iecic_max** (rinse_off): ≤ 0.5% — NMPA IECIC (2025) Entry 08571 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Phytosphingosine is a sphingolipid-derived bioactive compound exhibiting multifunctional properties including antimicrobial activity, skin moisturization, and hydration, rendering it highly valuable for cosmetic and pharmaceutical applications.
N-acyl-phytosphingosine is effective in improving impaired skin barrier function, alleviates UVB-induced barrier damage, increases expression of filaggrin and loricrin, and reduces sunburn cell count.
Phytosphingosine upregulates key genes involved in ceramide biosynthesis, keratinocyte proliferation, and differentiation.
Upon topical application, phytosphingosine significantly improves barrier function by reducing transepidermal water loss and erythema while increasing skin thickness and density.
Phytosphingosine induces cell death in fibroblasts and reduces fibrosis progression.
In the multilamellar lipid matrix of stratum corneum, phytosphingosine-based ceramides (NP and AP) exhibit more CO hydrogen bonds compared to sphingosine-based ceramides (NS and AS), consistent with lower amide I FTIR frequencies.
The hydroxyl group on the phytosphingosine base increases CO hydrogen bonding, affecting the structural organization of stratum corneum.

## 6. Linked PubMed Literature
- [PMID: 41809528] Efficacy Evaluation of N-Acyl-Phytosphingosine Prepared from Marula Oil Derived Fatty Acids in Skin Barrier Repair — *Clin Cosmet Investig Dermatol* (2026)
- [PMID: 41521012] Multiscale simulation of stratum corneum lipid mixtures: effects of ceramide headgroups on structural organization and hydrogen bonding networks — *Int J Pharm* (2026)
- [PMID: 42309385] X-ray Irradiation Suppresses Keloid Growth by Inducing G2/M Arrest via the Phytosphingosine-KIF20A Axis — *J Invest Dermatol* (2026)
- [PMID: 40642378] Construction of engineered Saccharomyces cerevisiae for producing phytosphingosine — *3 Biotech* (2025)
- [PMID: 41737990] Untargeted Metabolomics Investigating the Intracellular Metabolic Alterations of HaCaT Cells Treated with Isotretinoin — *Drug Des Devel Ther* (2026)
- [PMID: 41570988] Acid ceramidase ASAH1 is a key regulator of epidermal ceramide levels and composition — *J Biol Chem* (2026)
- [PMID: 41532096] Oral administration of Lacticaseibacillus rhamnosus HM126 alleviates DNFB-induced atopic dermatitis in BALB/c mice by modulating immunity, gut microbiota, and metabolites — *Front Immunol* (2025)
- [PMID: 41410490] Hyaluronic Acid-Modified Nanoemulsions Enable Targeted Transdermal Delivery of Hydroxypinacolone Retinoate — *ACS Appl Bio Mater* (2026)
- [PMID: 41319169] Investigation into the delivery and evaluation of a unique Avena sativa (Oat) Lipid Extract on skin barrier using LC‒MS/MS, Raman spectroscopy, immunostaining analysis and skin efficacy — *Int J Cosmet Sci* (2026)
- [PMID: 40424481] Structure-Function Relationship of the Most Abundant Ceramide Subspecies Studied on Monolayer Models Using GIXD and Langmuir Isotherms — *Langmuir* (2025)
- [PMID: 40408261] Topical supplementation with physiological lipids rebalances the stratum corneum ceramide profile and strengthens skin barrier function in adults predisposed to atopic dermatitis — *Br J Dermatol* (2025)
- [PMID: 40043273] INDIVIDUAL ARTICLE: A Clinical Evaluation of Scalp Barrier Function, Ceramide Levels, and Microbiome in Diverse Dandruff Patients — *J Drugs Dermatol* (2025)