# PETROLATUM (petrolatum) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/petrolatum
- **Standard INCI**: `PETROLATUM`
- **KR MFDS Standard Name**: `페트롤라툼`
- **CAS No.**: `8009-03-8`
- **EC / EINECS No.**: `232-373-2`
- **Origin**: `mineral`
- **Functions**: 대전방지제, 에모리엔트
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 페트롤라툼 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | PETROLATUM |
| US (PCPC / MoCRA INCI) | PETROLATUM |
| US (FDA OTC Monograph) | PETROLATUM |
| CN (NMPA IECIC) | 矿脂 |
| JP (JCIA / MHLW QD) | ワセリン (QD: 白色ワセリン) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `noted`
- **EU (1223/2009)**: `banned`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `noted` (Entry: `4185`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`

- **EU** [banned]: — —  (Regulation (EC) No 1223/2009 Annex II — via CosIng (EU Commission))
- **KR** [noted]: — —  (화장품 안전기준 등에 관한 규정 [별표1] 사용할 수 없는 원료)
- **CN** [noted]: — —  (化妆品安全技术规范(2015년판) — 表1)

## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: PETROLATUM | CAS No.: 8009-03-8 | EC No.: 232-373-2
  - Origin: MINERAL | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [PETROLATUM] · EU [PETROLATUM] · CN [矿脂] · JP [ワセリン] · JP Quasi-Drug [白色ワセリン]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Petrolatum. A complex combination of hydrocarbons obtained as a semi-solid from dewaxing paraffinic residual oil. It consists predominantly of saturated crystalline and liquid hydrocarbons having carbon numbers predominantly greater than C25 Classified under origin 'mineral', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NOTED | EU: BANNED | US: NONE | CN: NOTED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 4185 (矿脂))
  - [KR / COMPOSITION / noted]: 
  - [EU / COMPOSITION / banned]: 
  - [CN / COMPOSITION / noted]: 
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 2.0 ~ 18.0% (Median 4.55%, Ref: Global Starter Formulation Library Statistical Distribution (n=11, EVONIK 10 · SEPPIC 1)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: PETROLATUM
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 42300754 (2026, Microbiol Spectr): Antibacterial activity of glycerol monolaurate formulated in petrolatum
  - PMID 41825358 (2026, Burns): Microstructured silicone membrane as an ultra-microskin grafting cover: Transparent and promoting wound healing
  - PMID 41713054 (2026, Burns): Effects of polymer oxygenated alginate dressings for healing skin graft donor areas: A phase III randomized controlled t

## 6. Linked PubMed Literature
- [PMID: 42300754] Antibacterial activity of glycerol monolaurate formulated in petrolatum — *Microbiol Spectr* (2026)
- [PMID: 41825358] Microstructured silicone membrane as an ultra-microskin grafting cover: Transparent and promoting wound healing — *Burns* (2026)
- [PMID: 41713054] Effects of polymer oxygenated alginate dressings for healing skin graft donor areas: A phase III randomized controlled trial — *Burns* (2026)
- [PMID: 42184978] Contact Allergy to Topical Corticosteroids in Atopic Dermatitis: Diagnostic Gaps in Baseline Patch Testing — *Contact Dermatitis* (2026)
- [PMID: 42184966] Tapinarof as a Likely Contact Allergen: Evidence From Patch Testing of Allergic and Irritant Contact Dermatitis — *Contact Dermatitis* (2026)
- [PMID: 42116742] Evaluating Medicaid Coverage for Over-the-Counter Treatments for Diaper Dermatitis — *Pediatr Dermatol* (2026)
- [PMID: 42099181] Allergic Contact Dermatitis to 1,3-Diphenylguanidine Over a 23-Year Period: Recent Cases Involve Sterile Polyisoprene Gloves — *Contact Dermatitis* (2026)
- [PMID: 41905627] Mixing povidone-iodine and erythromycin ointment in skin wound management: a reconsidered practice — *J Am Acad Dermatol* (2026)
- [PMID: 41773167] Concomitant Use of Dermo-Cosmetic Skin Care in Aesthetic Procedures: Systematic Review with Expert Panel Recommendations — *Clin Cosmet Investig Dermatol* (2026)
- [PMID: 41766254] Higher Prevalence of Contact Sensitization to Dodecyl Gallate in Patients With Atopic Dermatitis: A Cross-Sectional Study — *Dermatitis* (2026)
- [PMID: 41599117] The Impact of Vehicle Occlusivity on Skin Delivery and Activity of a Janus Kinase Inhibitor: Comparison of Oil-Based Formulations — *Pharmaceutics* (2025)
- [PMID: 41540520] The Influence of Phyto-Active Incorporated Topical Formulations on Cell Migration in Scratch Assays and In vivo Wound Model in Mice — *Curr Drug Deliv* (2026)