# PANTHENOL (panthenol) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/panthenol
- **Standard INCI**: `PANTHENOL`
- **KR MFDS Standard Name**: `판테놀`
- **CAS No.**: `81-13-0`
- **EC / EINECS No.**: `201-327-3`
- **Origin**: `vitamin`
- **Functions**: 대전방지제, 모발컨디셔닝제, 피부컨디셔닝제
- **Molecular Formula / MW**: `C9H19NO4` (205.25 g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 판테놀 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | PANTHENOL |
| US (PCPC / MoCRA INCI) | PANTHENOL |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 泛醇 |
| JP (JCIA / MHLW QD) | パンテノール (QD: Ｄ－パントテニルアルコール) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `noted`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `2292`)
- **JP (MHLW)**: `restricted`
- **ASEAN (ACD)**: `none`

- **JP** [limited]: ≤ 8% —  (化粧品に配合可能な医薬品の成分について(薬食審査発第0524001号) 별첨 「承認化粧品成分の範囲」)
- **KR** [noted]: — —  (기능성화장품 기준 및 시험방법 [별표9])

## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 13% — NMPA IECIC (2025) Entry 02153 (2025)
- **cn_iecic_max** (rinse_off): ≤ 10% — NMPA IECIC (2025) Entry 02153 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 6.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: MADECASSOSIDE, CERAMIDE NP, ALLANTOIN, NIACINAMIDE, ECTOIN
- **Incompatibilities**: Hydrolyzes outside pH 4.0~7.0 or under prolonged heating > 75°C; High dosages (3~5%) impart noticeable tackiness; balance with light alkanes, elastomers, or silica

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: PANTHENOL | CAS No.: 81-13-0 | EC No.: 201-327-3
  - Origin: VITAMIN | Functions: , , 
  - Physicochemical Profile: Formula C9H19NO4 | MW 205.25 g/mol | LogP -1.06 | Ionic Nature: non-ionic | PubChem CID 4678
  - Official Regional Label Names: US [PANTHENOL] · EU [PANTHENOL] · CN [泛醇] · JP [パンテノール] · JP Quasi-Drug [Ｄ－パントテニルアルコール]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Provitamin B5 alcohol that penetrates the epidermis and converts enzymatically into pantothenic acid, an essential component of Coenzyme A (CoA). Accelerates epidermal lipid synthesis, fibroblast proliferation, and re-epithelialization while reducing transepidermal water loss (TEWL) and irritation.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NOTED | EU: NONE | US: NONE | CN: ALLOWED | JP: RESTRICTED | ASEAN: NONE (CN IECIC (2025) Entry No. 2292 (泛醇))
  - [KR / COMPOSITION / noted]: 
  - [JP / COMPOSITION / limited] (Max 8%): 
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 13.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 10.0%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.2 ~ 5.0% (Median 1.0%, Ref: DSM D-Panthenol Monograph & CIR Panthenol Assessment) — Provitamin B5 humectant, soothing & epithelial barrier repair active
  - [emulsion_cream] Typical range: 0.5 ~ 5.0% (Median 2.0%, Ref: CIR Panthenol Reported Use & PubMed Clinical Trials) — High-strength (3~5%) barrier repair cica balm & cream active
  - [anhydrous_balm] Typical range: 0.5 ~ 0.5% (Median 0.5%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, ELEMENTIS 2 · GRANT 2 · EVONIK 1)) — Anhydrous balm, oil & stick structural emollient
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Cool-down Phase (< 65°C) or warm Water Phase
  - Optimal pH Range: pH 4.5 ~ 6.5 | Max Process Temp: Max 70°C | Electrolyte Tolerance: HIGH
  - Incompatibility / Caution: Hydrolyzes outside pH 4.0~7.0 or under prolonged heating > 75°C
  - Incompatibility / Caution: High dosages (3~5%) impart noticeable tackiness; balance with light alkanes, elastomers, or silica
  - Synergy Pairings: MADECASSOSIDE, CERAMIDE NP, ALLANTOIN, NIACINAMIDE, ECTOIN | Reference Trade Names: D-Panthenol 75W, Dexpanthenol USP/EP
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 12113650 (2002, Am J Clin Dermatol): Topical use of dexpanthenol in skin disorders
  - PMID 28503966 (2017, J Dermatolog Treat): Topical use of dexpanthenol: a 70th anniversary article
  - PMID 39528008 (2024, Photodiagnosis Photodyn Ther): Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A ran

## 6. Linked PubMed Literature
- [PMID: 12113650] Topical use of dexpanthenol in skin disorders — *Am J Clin Dermatol* (2002)
- [PMID: 28503966] Topical use of dexpanthenol: a 70th anniversary article — *J Dermatolog Treat* (2017)
- [PMID: 39528008] Prebiotic and panthenol-containing dermocosmetic improves tolerance from artificial daylight photodynamic therapy: A randomized controlled trial in patients with actinic keratosis — *Photodiagnosis Photodyn Ther* (2024)
- [PMID: 32610604] Dexpanthenol in Wound Healing after Medical and Cosmetic Interventions (Postprocedure Wound Healing) — *Pharmaceuticals (Basel)* (2020)
- [PMID: 35887707] Use of Dexpanthenol for Atopic Dermatitis-Benefits and Recommendations Based on Current Evidence — *J Clin Med* (2022)
- [PMID: 21982351] Skin moisturizing effects of panthenol-based formulations — *J Cosmet Sci* (2011)
- [PMID: 42108609] Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial — *J Cosmet Dermatol* (2026)
- [PMID: 42053970] A Prebiotic and Panthenol-Containing Repair Balm Improves Tolerability of Topical 5-Fluorouracil Field Therapy for Actinic Keratoses: A Randomised Controlled Trial — *Dermatol Ther (Heidelb)* (2026)
- [PMID: 42025121] Assessment of oxidative and inflammatory biomarkers in denture-related traumatic ulcers treated with different topical agents — *Arch Oral Biol* (2026)
- [PMID: 40905518] Strengthening benefits of panthenol for hair: Mechanistic evidence from advanced spectroscopic techniques — *Int J Cosmet Sci* (2026)
- [PMID: 41983181] Azelaic acid-integrated therapeutic deep eutectic systems: overcoming solubility and permeability barriers for enhanced transdermal drug delivery — *RSC Adv* (2026)
- [PMID: 42269767] Prostaglandin analogues in cosmetic products formulated for eyelash lengthening — *Ann Pharm Fr* (2026)
- [PMID: 42212981] Open-label, uncontrolled clinical investigation of the performance and safety of a foam containing a hyaluronic acid-derived biopolymer and humectants for management of dermatitis in adults — *Ital J Dermatol Venerol* (2026)
- [PMID: 41891349] The efficacy of a bioactive moisturizer in mitigating side effects of acne therapies: a randomized, investigator-blind, split-face trial — *Dermatol Reports* (2026)
- [PMID: 41740945] Fabrication and Evaluation of 3D-printed Dittany-infused Patches for Anti-inflammatory Dermatological Applications — *Planta Med* (2026)
- [PMID: 41599383] Experimental Valorization of Recycled Palm Oil in Topical Formulations: Preparation, Characterization, and Antimicrobial Assessment — *Molecules* (2026)
- [PMID: 41304500] From Safety Evaluation to Influencing Factors Analysis: A Comprehensive Investigation on Ocular Irritation of Baby Bath Products — *Toxics* (2025)
- [PMID: 40957858] A Split-Face Randomized Study on the Efficacy of a Platinum-Liposome-Based Facial Mask Containing Soothing Ingredients for Post-Photorejuvenation Skin Recovery — *J Cosmet Dermatol* (2025)