# MICA (mica) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/mica
- **Standard INCI**: `MICA`
- **KR MFDS Standard Name**: `마이카`
- **CAS No.**: `12001-26-2`
- **EC / EINECS No.**: `601-648-2`
- **Origin**: `mineral`
- **Functions**: 색소, 불투명화제, 고결방지제, 증량제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 마이카 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | MICA |
| US (PCPC / MoCRA INCI) | MICA |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 云母 |
| JP (JCIA / MHLW QD) | MICA  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `noted`
- **US (FDA/MoCRA)**: `restricted`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8458`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`

- **US** [restricted]: — — [US RESTRICTED] * Eye Area : Yes 
* 눈 주위 : 사용가능 
* Generally  (Includes  Lipsticks) : Yes 
* 일반적인 사용 (립스틱 포함) : 사용가능 
* External Use : Yes 
* 외용 : 사용가능 (식약처 국가별 사용제한원료정보 API (미국))
- **EU** [noted]: — —  (Regulation (EC) No 1223/2009 Annex IV — via CosIng (EU Commission))

## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Mica is widely used in cosmetics such as foundations, eyeshadows, lipsticks, and nail polishes for its pearlescent and shimmering effects.
Muscovite contains Al₂O₃ (30.46%) and SiO₂ (49.29%), while biotite and phlogopite are enriched in Fe₂O₃ (43%) and MgO, supporting shimmer, color, and UV-protective properties.
X-ray diffraction confirmed high crystallinity and purity.
Mica samples showed a primary irritation index (PII) of 0.00 in skin irritation testing, indicating non-irritant properties.
Non-carcinogenic and carcinogenic risk assessments revealed heavy metals within safe dermal and inhalation exposure limits with low heavy metal content.
Sensory evaluation demonstrated silky texture, strong adhesion, and a luminous finish.
Biotite and phlogopite exhibited moderate antibacterial activity against Staphylococcus aureus, Salmonella typhi, and Bacillus megaterium, but no antifungal effects.
Muscovite, biotite, and phlogopite mica show low heavy metal content, non-irritant and non-carcinogenic behavior, moderate antibacterial activity, and favorable sensory properties, highlighting their potential as safe and effective multifunctional cosmetic ingredients.

## 6. Linked PubMed Literature
- [PMID: 40951932] Toxicological Safety, Antimicrobial Efficacy, and Sensory Evaluation of River Sand-Derived Mica From Bangladesh: A Comprehensive Assessment for Cosmetic Applications — *J Cosmet Dermatol* (2025)
- [PMID: 42183286] NK cell hyperactivation drives macrophage repolarization and limits M2 bias in pemphigus vulgaris — *Front Immunol* (2026)
- [PMID: 42116516] Xylooligosaccharides ameliorate intestinal barrier injury by inhibiting apoptosis, RhoA/ROCK/MLCK signaling and NKG2DLs in intestinal epithelial cells — *Food Res Int* (2026)
- [PMID: 41905023] Characterization of an inherited HLA-B gene deletion in a candidate for hematopoietic cell transplantation — *Hum Immunol* (2026)
- [PMID: 41861437] The association of selected genetic polymorphisms with adverse events following COVID-19 vaccination: a single-centre prospective observational cohort study — *Virology* (2026)
- [PMID: 41683735] Calreticulin-Mediated Quality Control of the Non-Classical MHC-I Molecule MICA: Implications for Immune Surveillance — *Int J Mol Sci* (2026)
- [PMID: 41579939] Toward cell-based therapy of alopecia areata: Autologous human Vδ2(+) Foxp3(+) γδTreg cells restore hair-follicle immune privilege and promote hair regrowth in human alopecia areata models ex vivo and in vivo — *J Invest Dermatol* (2026)
- [PMID: 41511820] Unraveling and Sliding of Polypeptide Strands Underlies the Exceptional Toughness of the Triple-Helix Collagen Molecule — *ACS Nano* (2026)
- [PMID: 40940136] Analysis of treatment-free survival of patients with advanced melanoma receiving nivolumab as monotherapy or in combination with relatlimab in RELATIVITY-047 — *J Immunother Cancer* (2025)
- [PMID: 40863176] Antiparasitic Effect of Polyphenols and Terpenes from Natural Products Against Trypanosoma cruzi and Leishmania mexicana — *Metabolites* (2025)
- [PMID: 40728165] Surface Forces and Frictional Properties of Adsorbed Biobased Cationic Polysaccharide Thin Films in Salted Aqueous Medium — *Langmuir* (2025)
- [PMID: 40628501] Association of MICA gene polymorphisms and SNP loci with susceptibility to rosacea — *Zhong Nan Da Xue Xue Bao Yi Xue Ban* (2025)