# LECITHIN (lecithin) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/lecithin
- **Standard INCI**: `LECITHIN`
- **KR MFDS Standard Name**: `레시틴`
- **CAS No.**: `8002-43-5`
- **EC / EINECS No.**: `232-307-2`
- **Origin**: `plant`
- **Functions**: 대전방지제, 피부컨디셔닝제, 에모리엔트, 유화제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 레시틴 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | LECITHIN |
| US (PCPC / MoCRA INCI) | LECITHIN |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 卵磷脂 |
| JP (JCIA / MHLW QD) | LECITHIN  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `4456`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: LECITHIN | CAS No.: 8002-43-5 | EC No.: 232-307-2
  - Origin: PLANT | Functions: , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [LECITHIN] · EU [LECITHIN] · CN [卵磷脂] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Lecithins. The complex combination of diglycerides of fatty acids linked to the choline ester of phosphoric acid Classified under origin 'plant', it acts within the cosmetic vehicle or stratum corneum to deliver , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 4456 (卵磷脂))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 0.05 ~ 5.0% (Median 0.75%, Ref: Global Starter Formulation Library Statistical Distribution (n=10, GRANT 9 · ELEMENTIS 1)) — Emulsion cream & lotion structural / conditioning agent
  - [sun_color] Typical range: 0.3 ~ 1.5% (Median 1.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=25, GRANT 25)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: LECITHIN
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 41987370 (2026, Skin Res Technol): Shake-Induced Temporary Ion-Pairing Between Lecithin and Glycolic Acid for Enhanced Exfoliation in a Novel Biphasic Seru
  - PMID 42013529 (2026, J Colloid Interface Sci): Unravelling the mechanisms behind the stabilization of oil foams using soybean lecithin
  - PMID 41913074 (2026, J Sci Food Agric): Recycling of hazelnut waste: Antidiabetic properties of soy lecithin nanoparticles and their in vitro anti-proliferative

## 6. Linked PubMed Literature
- [PMID: 41987370] Shake-Induced Temporary Ion-Pairing Between Lecithin and Glycolic Acid for Enhanced Exfoliation in a Novel Biphasic Serum: Comparative Ex Vivo and in Vivo Randomised Studies — *Skin Res Technol* (2026)
- [PMID: 42013529] Unravelling the mechanisms behind the stabilization of oil foams using soybean lecithin — *J Colloid Interface Sci* (2026)
- [PMID: 41913074] Recycling of hazelnut waste: Antidiabetic properties of soy lecithin nanoparticles and their in vitro anti-proliferative effects in tumor cell lines — *J Sci Food Agric* (2026)
- [PMID: 42246630] Retinol-Loaded Mannosylerythritol Lipid Nanoliposome for Enhanced Human Skin Penetration — *Skin Res Technol* (2026)
- [PMID: 42242510] Stratum corneum lipid remodeling as a proposed mechanism for liposomal penetration enhancement — *Eur J Pharm Biopharm* (2026)
- [PMID: 42190786] Impact of cationic, anionic, and amphiphilic emulsifiers on the physicochemical properties and applications of xanthan gum-shea butter bigels — *Int J Biol Macromol* (2026)
- [PMID: 42173826] A Kangfuxin-Loaded Lipid Gel for the Management of Radiation Dermatitis: Repair and Protection — *ACS Appl Mater Interfaces* (2026)
- [PMID: 42123793] Comparison of Selected Pro-Health Biologically Active Chemical Compounds in Salviae herba from Selected Species — *Molecules* (2026)
- [PMID: 42084848] Assessment of skin permeation and anti-inflammatory efficacy of lornoxicam proniosomal topical gel formulations: a comparative study — *Pharm Dev Technol* (2026)
- [PMID: 42083964] Photodynamic Versus Sonodynamic Therapy In Vitro: Antimicrobial Activity of Liposomal Rose Bengal — *Curr Drug Deliv* (2026)
- [PMID: 42083811] Pregabalin-loaded transferosomal gel for enhanced topical delivery in peripheral neuropathy: formulation, in vitro and ex vivo evaluation — *Drug Dev Ind Pharm* (2026)
- [PMID: 41937363] Cationic Corona-Engineered Polymer-Lipid Hybrid Nanoparticles for Enhanced Dermal Penetration and Cellular Bioavailability — *Langmuir* (2026)