# ISOPROPYL PALMITATE (isopropyl-palmitate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/isopropyl-palmitate
- **Standard INCI**: `ISOPROPYL PALMITATE`
- **KR MFDS Standard Name**: `아이소프로필팔미테이트`
- **CAS No.**: `142-91-6`
- **EC / EINECS No.**: `205-571-1`
- **Origin**: `synthetic`
- **Functions**: 향료, 결합제, 에모리엔트
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 아이소프로필팔미테이트 |
| KR (Former Names) | 이소프로필팔미테이트 |
| EU (CosIng 1223/2009) | ISOPROPYL PALMITATE |
| US (PCPC / MoCRA INCI) | ISOPROPYL PALMITATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 棕榈酸异丙酯 |
| JP (JCIA / MHLW QD) | ISOPROPYL PALMITATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8718`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ISOPROPYL PALMITATE | CAS No.: 142-91-6 | EC No.: 205-571-1
  - Origin: SYNTHETIC | Functions: , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ISOPROPYL PALMITATE] · EU [ISOPROPYL PALMITATE] · CN [棕榈酸异丙酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - ISOPROPYL PALMITATE functions primarily as , ,  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8718 (棕榈酸异丙酯))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [anhydrous_balm] Typical range: 2.0 ~ 30.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 5 · ELEMENTIS 1 · GRANT 1)) — Anhydrous balm, oil & stick structural emollient
  - [emulsion_cream] Typical range: 0.4 ~ 12.0% (Median 4.85%, Ref: Global Starter Formulation Library Statistical Distribution (n=28, EVONIK 28)) — Emulsion cream & lotion structural / conditioning agent
  - [sun_color] Typical range: 2.0 ~ 7.0% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 4 · GRANT 1)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ISOPROPYL PALMITATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 29318715 (2018, J Cosmet Dermatol): Comparative evaluation of skin moisture after topical application of 10% and 30% lactobionic acid.
  - PMID 27169828 (2016, Int J Cosmet Sci): Determination and confirmation of isopropyl p-toluenesulfonate in cosmetics by HPLC-diode array detector method and GC-M
  - PMID 36878583 (2023, J Oleo Sci): Preparation and In Vitro Evaluation of W/O Nanoemulsions for the Skin Permeation of 5-Aminolevulinic Acid.

## 6. Linked PubMed Literature
- [PMID: 29318715] Comparative evaluation of skin moisture after topical application of 10% and 30% lactobionic acid. — *J Cosmet Dermatol* (2018)
- [PMID: 27169828] Determination and confirmation of isopropyl p-toluenesulfonate in cosmetics by HPLC-diode array detector method and GC-MS. — *Int J Cosmet Sci* (2016)
- [PMID: 36878583] Preparation and In Vitro Evaluation of W/O Nanoemulsions for the Skin Permeation of 5-Aminolevulinic Acid. — *J Oleo Sci* (2023)
- [PMID: 32196480] Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel. — *Int J Pharm Compd* (2020)