# ISOPROPYL MYRISTATE (isopropyl-myristate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/isopropyl-myristate
- **Standard INCI**: `ISOPROPYL MYRISTATE`
- **KR MFDS Standard Name**: `아이소프로필미리스테이트`
- **CAS No.**: `110-27-0`
- **EC / EINECS No.**: `203-751-4`
- **Origin**: `synthetic`
- **Functions**: 향료, 결합제, 에모리엔트
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 아이소프로필미리스테이트 |
| KR (Former Names) | 이소프로필미리스테이트 |
| EU (CosIng 1223/2009) | ISOPROPYL MYRISTATE |
| US (PCPC / MoCRA INCI) | ISOPROPYL MYRISTATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 肉豆蔻酸异丙酯 |
| JP (JCIA / MHLW QD) | ISOPROPYL MYRISTATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `5608`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ISOPROPYL MYRISTATE | CAS No.: 110-27-0 | EC No.: 203-751-4
  - Origin: SYNTHETIC | Functions: , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ISOPROPYL MYRISTATE] · EU [ISOPROPYL MYRISTATE] · CN [肉豆蔻酸异丙酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - ISOPROPYL MYRISTATE functions primarily as , ,  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 5608 (肉豆蔻酸异丙酯))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 0.8 ~ 18.0% (Median 6.15%, Ref: Global Starter Formulation Library Statistical Distribution (n=14, EVONIK 12 · SEPPIC 2)) — Emulsion cream & lotion structural / conditioning agent
  - [sun_color] Typical range: 1.5 ~ 10.0% (Median 3.55%, Ref: Global Starter Formulation Library Statistical Distribution (n=10, ELEMENTIS 7 · EVONIK 3)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ISOPROPYL MYRISTATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 35127174 (2022, J Adv Res): Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures.
  - PMID 31652587 (2019, Pharmaceutics): Preparation, Characterisation, and Topical Delivery of Terbinafine.
  - PMID 28976900 (2017, Folia Med (Plovdiv)): Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid.

## 6. Linked PubMed Literature
- [PMID: 35127174] Skin cancer biology and barriers to treatment: Recent applications of polymeric micro/nanostructures. — *J Adv Res* (2022)
- [PMID: 31652587] Preparation, Characterisation, and Topical Delivery of Terbinafine. — *Pharmaceutics* (2019)
- [PMID: 28976900] Nuts and Bolts of Oil and Temperature in Topical Preparations of Salicylic Acid. — *Folia Med (Plovdiv)* (2017)