# HYDROXYPINACOLONE RETINOATE (hydroxypinacolone-retinoate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/hydroxypinacolone-retinoate
- **Standard INCI**: `HYDROXYPINACOLONE RETINOATE`
- **KR MFDS Standard Name**: `하이드록시피나콜론레티노에이트`
- **CAS No.**: `N/A`
- **EC / EINECS No.**: `N/A`
- **Origin**: `vitamin`
- **Functions**: 피부컨디셔닝제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 하이드록시피나콜론레티노에이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | HYDROXYPINACOLONE RETINOATE |
| US (PCPC / MoCRA INCI) | HYDROXYPINACOLONE RETINOATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 羟基频哪酮视黄酸酯 |
| JP (JCIA / MHLW QD) | HYDROXYPINACOLONE RETINOATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `5269`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 0.5% — NMPA IECIC (2025) Entry 05390 (2025)
- **cn_iecic_max** (rinse_off): ≤ 0.2% — NMPA IECIC (2025) Entry 05390 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: HYDROXYPINACOLONE RETINOATE | CAS No.: N/A | EC No.: N/A
  - Origin: VITAMIN | Functions: Skin Conditioning
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [HYDROXYPINACOLONE RETINOATE] · EU [HYDROXYPINACOLONE RETINOATE] · CN [羟基频哪酮视黄酸酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Ester of all-trans retinoic acid that binds directly to retinoid nuclear receptors (RAR) without requiring metabolic conversion. Stimulates cellular turnover and extracellular matrix gene expression with a markedly lower irritation and erythema profile than traditional retinol.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 5269 (羟基频哪酮视黄酸酯))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 0.5% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 0.2%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - Dosage engineered according to primary function  and phase solubility.
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Standard Phase 
  - Optimal pH Range: pH 4.5 ~ 7.5  | Max Process Temp:     | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Perform preliminary compatibility testing when combining with strong electrolytes or extreme pH actives
  - Synergy Pairings: GLYCERIN, PANTHENOL, TOCOPHEROL | Reference Trade Names: HYDROXYPINACOLONE RETINOATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

## 6. Linked PubMed Literature