# HYDROGENATED LECITHIN (hydrogenated-lecithin) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/hydrogenated-lecithin
- **Standard INCI**: `HYDROGENATED LECITHIN`
- **KR MFDS Standard Name**: `하이드로제네이티드레시틴`
- **CAS No.**: `92128-87-5`
- **EC / EINECS No.**: `295-786-7`
- **Origin**: `synthetic`
- **Functions**: 피부컨디셔닝제, 유화제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 하이드로제네이티드레시틴 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | HYDROGENATED LECITHIN |
| US (PCPC / MoCRA INCI) | HYDROGENATED LECITHIN |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 氢化卵磷脂 |
| JP (JCIA / MHLW QD) | 水添レシチン (QD: 水素添加大豆リン脂質) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `5378`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 8% — NMPA IECIC (2025) Entry 05461 (2025)
- **cn_iecic_max** (rinse_off): ≤ 5% — NMPA IECIC (2025) Entry 05461 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Hydrogenated lecithin is a stabilized phospholipid-based ingredient derived from plants, primarily composed of phosphatidylcholine and phosphatidylethanolamine.
It serves as a key component in various nanocarrier systems including liposomes, transfersomes, and liquid crystalline nanoparticles, improving the delivery of substances such as retinol, flurbiprofen, and trans-resveratrol.
It forms a lamellar liquid crystal structure similar to the skin stratum corneum, offering broad application potential in cosmetic and pharmaceutical delivery systems.
It functions as an emulsifier and wetting agent, with higher phosphatidylcholine content (90-100%) forming well-defined lamellar phases and charge-free monolayers.
Hydrogenated phospholipids demonstrate high solubility in multiple cosolvents, facilitating the incorporation of phospholipids into dermal formulations.
It improves physicochemical properties including nanoparticle size, zeta potential, and encapsulation efficiency, providing sustained release and moisturizing performance.
Its stability and flexibility as a carrier support the skin delivery of various bioactive substances, including biomimetic peptides.

## 6. Linked PubMed Literature
- [PMID: 42246630] Retinol-Loaded Mannosylerythritol Lipid Nanoliposome for Enhanced Human Skin Penetration — *Skin Res Technol* (2026)
- [PMID: 41235541] Minimalist, bioinspired and sensorial emulsion based on a Ca(2+) double cone vector system using Design of Experiment (DoE) — *Int J Cosmet Sci* (2026)
- [PMID: 40425131] Hydrogenated plant-based lecithins as excipients for cosmetic and pharmaceutical applications: A physical-chemical study — *Eur J Pharm Sci* (2025)
- [PMID: 38171800] Application of Hydrogenated Soya Lecithin in Solid Dispersion and Oily Gel, and the Study of Skin-Applied Formulations — *Yakugaku Zasshi* (2024)
- [PMID: 37896245] Liposomes as Carriers of GHK-Cu Tripeptide for Cosmetic Application — *Pharmaceutics* (2023)
- [PMID: 35361319] Preparation and Evaluation of Pluronic Lecithin Organogels in Cosmetics — *J Cosmet Sci* (2021)
- [PMID: 26201345] In vitro Percutaneous Absorption of Niacinamide and Phytosterols and in vivo Evaluation of their Effect on Skin Barrier Recovery — *Curr Drug Deliv* (2016)
- [PMID: 25948327] Glyceryl monooleyl ether-based liquid crystalline nanoparticles as a transdermal delivery system of flurbiprofen: characterization and in vitro transport — *Chem Pharm Bull (Tokyo)* (2015)
- [PMID: 24139433] Formulation strategies to modulate the topical delivery of anti-inflammatory compounds — *J Cosmet Sci* (2013)
- [PMID: 40765893] Development and Evaluation of Trans-Resveratrol-Loaded Transfersomes: Role of Cholesterol in Formulation Design for Dermal Delivery — *Nanotechnol Sci Appl* (2025)
- [PMID: 38554094] Construction and Properties of O/W Liquid Crystal Nanoemulsion — *Langmuir* (2024)
- [PMID: 34391854] A novel drug delivery system -- Drug crystallization encapsulated liquid crystal emulsion — *Int J Pharm* (2021)