# HOMOSALATE (homosalate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/homosalate
- **Standard INCI**: `HOMOSALATE`
- **KR MFDS Standard Name**: `호모살레이트`
- **CAS No.**: `118-56-9`
- **EC / EINECS No.**: `204-260-8`
- **Origin**: `synthetic`
- **Functions**: 향료, 자외선차단제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 호모살레이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | HOMOSALATE |
| US (PCPC / MoCRA INCI) | HOMOSALATE |
| US (FDA OTC Monograph) | HOMOSALATE |
| CN (NMPA IECIC) | 胡莫柳酯 |
| JP (JCIA / MHLW QD) | HOMOSALATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `restricted`
- **EU (1223/2009)**: `restricted`
- **US (FDA/MoCRA)**: `restricted`
- **CN (NMPA IECIC)**: `restricted` (Entry: `2932`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`

- **KR** [limited]: ≤ 10% —  (화장품 사용제한 원료 정보 (식약처 오픈API · 안전기준 [별표2]))
- **EU** [limited]: ≤ 7.34% —  (Regulation (EC) No 1223/2009 Annex VI — via CosIng (EU Commission))
- **CN** [limited]: ≤ 10% —  (化妆品安全技术规范(2015년판) — 表5)
- **CN** [limited]: ≤ 10% —  (化妆品安全技术规范（2015年版）)
- **US** [restricted]: ≤ 15% — [US RESTRICTED] * 【Restrictions】
Maximum Concentration (제한) : 15% 
* Specific Limitations  and Comments : Use of the term "sunscreen" or similar sun protection wording in a product's labeling generally causes the product to be subject to regulation as a drug or a drug/cosmetic, depending on the claims. However, sunscreen ingredients may also be used in some cosmetic products to protect the products’ color. The labelling must also state why the sunscreen ingredient is used, for example, "Contains a sunscreen to protect product color." If this explanation isn’t present, the product may be subject to regulation as a drug (21 CFR 700.35). For more information on sunscreens, refer to Tanning Products 
* 특별 제한조건 : "선스크린"의 단어를 사용하거나 자외선 차단과 비슷한 단어를 사용할 경우, 해당 제품은 클레임(표시광고)에 따라 제약 또는 제약/화장품의 규정을 따라야 한다. ^그러나, 자외선 차단의 성분들은 제품의 색을 보호하는 역할로 사용되기도 한다. 자외선을 차단하는 성분이 사용된 목적에 대해 라벨링에 반드시 명시해야한다. 예를 들어, "제품의 색을 보호하기 위해 자외차단제 성분을 함유하고 있다." ^만약 이러한 설명을 라벨링에 하지 않는다면, 그 상품은 제약으로서의 규정에 따라야한다. (21 CFR 700.35) ^자외선 차단에 대한 정보가 궁금하면 태닝 제품을 참고하라. (식약처 국가별 사용제한원료정보 API (미국))
- **KR** [noted]: ≤ 10% —  (기능성화장품 심사에 관한 규정 [별표4] 자료제출이 생략되는 기능성화장품의 종류(제6조제3항 관련))

## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **reported_use** (face_cream): ≤ 7.34% — undefined (undefined)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: HOMOSALATE | CAS No.: 118-56-9 | EC No.: 204-260-8
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [HOMOSALATE] · EU [HOMOSALATE] · CN [胡莫柳酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Homosalate is the substituted phenolic compound that conforms to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: RESTRICTED | CN: RESTRICTED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 2932 (胡莫柳酯))
  - [CN / COMPOSITION / limited] (Max 10%): 
  - [CN / COMPOSITION / limited] (Max 10%): 
  - [KR / COMPOSITION / limited] (Max 10%): 
  - Official Safety & Historical Use Concentration (Layer 2): sccs (reported_use, face_cream): Max 7.34%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [sun_color] Typical range: 2.0 ~ 15.0% (Median 6.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=33, EVONIK 18 · GRANT 9 · SEPPIC 6)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: HOMOSALATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 41726609 (2026, ACS Omega): In Silico Perspective on Avobenzone, Octisalate, Octocrylene, Homosalate, and Bemotrizinol as Organic UV Filters Using D
  - PMID 41712751 (2026, Environ Toxicol Chem): Probabilistic emissions model for organic UV filters released to recreational waters during swimming/bathing events
  - PMID 41592362 (2026, Environ Int): Endogenous 15(S)-hydroxyeicosatetraenoic acid mediates amplified estrogenic responses under nanoplastic-homosalate coexp

## 6. Linked PubMed Literature
- [PMID: 41726609] In Silico Perspective on Avobenzone, Octisalate, Octocrylene, Homosalate, and Bemotrizinol as Organic UV Filters Using DFT, TD-DFT, and Molecular Dynamics — *ACS Omega* (2026)
- [PMID: 41712751] Probabilistic emissions model for organic UV filters released to recreational waters during swimming/bathing events — *Environ Toxicol Chem* (2026)
- [PMID: 41592362] Endogenous 15(S)-hydroxyeicosatetraenoic acid mediates amplified estrogenic responses under nanoplastic-homosalate coexposure — *Environ Int* (2026)
- [PMID: 42278310] Pyroptosis- and Necroptosis-Related Signaling in Salicylate UV Absorber-Induced Toxicity: Implications for Sustainable Chemistry and Human Health — *Int J Mol Sci* (2026)
- [PMID: 42084616] Laser-induced hyperspectral fluorescence for spatio-chemical detection of sunscreen contaminants in food-grade sea salt using sparse PCA-SVM analysis — *Environ Geochem Health* (2026)
- [PMID: 42067042] Pending Food and Drug Administration approval of bemotrizinol: A potential turning point for United States sunscreen formulation — *J Am Acad Dermatol* (2026)
- [PMID: 41730063] Sunscreens — *PubMed Journal* (2006)
- [PMID: 41544515] Development and preliminary validation of an analytical methodology for the determination of organic UV filters in zooplankton samples — *Mar Pollut Bull* (2026)
- [PMID: 41518963] Occurrence of twelve UV filters and evidence of cis-octinoxate formation in Adriatic coastal waters: Environmental implications — *Mar Pollut Bull* (2026)
- [PMID: 41319926] Assessing the hepatic metabolism of six sunscreen ultraviolet filters: In vitro-in vivo extrapolation approach using human liver microsomes and hepatic parameter predictions for exposure risk assessment — *Biochem Pharmacol* (2026)
- [PMID: 41236699] Green-synthesized Tio₂ Nanoparticles for Sunscreen: Eco-Friendly Approach to Spf Enhancement — *Appl Biochem Biotechnol* (2026)
- [PMID: 41101667] Nationwide occurrence of emerging benzophenone, benzotriazole, salicylate and triazine ultraviolet filters in coastal sediment of China: Spatial distribution, source and ecological risk — *Environ Res* (2025)