# HEXYLENE GLYCOL (hexylene-glycol) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/hexylene-glycol
- **Standard INCI**: `HEXYLENE GLYCOL`
- **KR MFDS Standard Name**: `헥실렌글라이콜`
- **CAS No.**: `107-41-5`
- **EC / EINECS No.**: `203-489-0`
- **Origin**: `synthetic`
- **Functions**: 피부컨디셔닝제, 용제, 유화제, 세정제, 향료
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 헥실렌글라이콜 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | HEXYLENE GLYCOL |
| US (PCPC / MoCRA INCI) | HEXYLENE GLYCOL |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 己二醇 |
| JP (JCIA / MHLW QD) | HEXYLENE GLYCOL  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3187`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: HEXYLENE GLYCOL | CAS No.: 107-41-5 | EC No.: 203-489-0
  - Origin: SYNTHETIC | Functions: Skin Conditioning, , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [HEXYLENE GLYCOL] · EU [HEXYLENE GLYCOL] · CN [己二醇] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - HEXYLENE GLYCOL functions primarily as , , , ,  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3187 (己二醇))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [cleanser_rinse] Typical range: 1.0 ~ 5.0% (Median 1.4%, Ref: Global Starter Formulation Library Statistical Distribution (n=9, EVONIK 5 · SEPPIC 4)) — Rinse-off cleanser & surfactant system modifier
  - [emulsion_cream] Typical range: 1.0 ~ 5.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=8, SEPPIC 6 · EVONIK 2)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: HEXYLENE GLYCOL
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 39248485 (2024, J Vis Exp): Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Techno
  - PMID 34256829 (2021, Allergy Asthma Clin Immunol): Methylprednisolone-induced anaphylaxis diagnosed by intradermal skin test: a case report
  - PMID 21180287 (2010, SADJ): Properties of a new mouthrinse for patients receiving radiation therapy

## 6. Linked PubMed Literature
- [PMID: 39248485] Microwave-Assisted Extraction of Phenolic Compounds and Antioxidants for Cosmetic Applications Using Polyol-Based Technology — *J Vis Exp* (2024)
- [PMID: 34256829] Methylprednisolone-induced anaphylaxis diagnosed by intradermal skin test: a case report — *Allergy Asthma Clin Immunol* (2021)
- [PMID: 21180287] Properties of a new mouthrinse for patients receiving radiation therapy — *SADJ* (2010)
- [PMID: 20185893] Contact urticaria with systemic symptoms due to hexylene glycol in a topical corticosteroid: case report and review of hypersensitivity to glycols — *Dermatology* (2010)
- [PMID: 16215760] Pentane-1,5-diol as a percutaneous absorption enhancer — *Arch Dermatol Res* (2005)
- [PMID: 12641331] Development of indomethacin Carbopol ETD 2001 gels and the influence of storage time and temperature on their stability — *Pharmazie* (2003)
- [PMID: 11933848] Pluronic F-127 gels as a vehicle for topical formulations of indomethacin and rheological behaviour of these formulations — *Pharmazie* (2002)
- [PMID: 11305382] An open study of efficacy and safety of long-term treatment with mometasone furoate fatty cream in the treatment of adult patients with atopic dermatitis — *J Eur Acad Dermatol Venereol* (2000)
- [PMID: 7903363] Further evaluation of a new penetration enhancer, HPE-101 — *J Pharm Pharmacol* (1993)
- [PMID: 37179601] Novel Insight into Pickering Emulsion and Colloidal Particle Network Construction of Basil Extract for Enhancing Antioxidant and UV-B-Induced Antiaging Activities — *ACS Omega* (2023)
- [PMID: 33233527] Investigations on Alkanediols as Alternative Preservatives in a Nonionic Hydrophilic Cream — *Pharmaceutics* (2020)
- [PMID: 12426950] Influence of storage time and temperature on the stability of indomethacin Pluronic F-127 gels — *Pharmazie* (2002)