# HELIANTHUS ANNUUS SEED OIL (helianthus-annuus-seed-oil) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/helianthus-annuus-seed-oil
- **Standard INCI**: `HELIANTHUS ANNUUS SEED OIL`
- **KR MFDS Standard Name**: `—`
- **CAS No.**: `84776-03-4`
- **EC / EINECS No.**: `232-273-9`
- **Origin**: `plant`
- **Functions**: 용제, 에모리엔트, 피부컨디셔닝제, 밀폐제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | — |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | HELIANTHUS ANNUUS SEED OIL |
| US (PCPC / MoCRA INCI) | HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | — |
| JP (JCIA / MHLW QD) | HELIANTHUS ANNUUS SEED OIL  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `none` (Entry: `—`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: HELIANTHUS ANNUUS SEED OIL | CAS No.: 84776-03-4 | EC No.: 232-273-9
  - Origin: PLANT | Functions: , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [HELIANTHUS ANNUUS (SUNFLOWER) SEED OIL] · EU [HELIANTHUS ANNUUS SEED OIL] · CN [-] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Helianthus Annuus Seed Oil is the fixed oil expressed from the seeds of the sunflower, Helianthus annuus. Classified under origin 'plant', it acts within the cosmetic vehicle or stratum corneum to deliver , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: NONE | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. Unlisted (-))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [anhydrous_balm] Typical range: 2.0 ~ 50.0% (Median 32.5%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 6 · ELEMENTIS 1)) — Anhydrous balm, oil & stick structural emollient
  - [aqueous_serum] Typical range: 0.5 ~ 10.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 4 · ELEMENTIS 1)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [cleanser_rinse] Typical range: 1.0 ~ 50.0% (Median 31.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, EVONIK 5 · ELEMENTIS 1)) — Rinse-off cleanser & surfactant system modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: HELIANTHUS ANNUUS SEED OIL
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 36582047 (2023, Contact Dermatitis): Severe contact cheilitis from cera alba and other cosmetic oils, fats and waxes in lip balms
  - PMID 39973828 (2024, Indian J Pharmacol): Exploring the mechanism of sunflower seed oil against Alzheimer's disease through experimental and network pharmacology 
  - PMID 12906355 (2003, Plant Foods Hum Nutr): Physical behavior of purified and crude wax obtained from sunflower (Helianthus annuus) seed oil refineries and seed hul

## 6. Linked PubMed Literature
- [PMID: 36582047] Severe contact cheilitis from cera alba and other cosmetic oils, fats and waxes in lip balms — *Contact Dermatitis* (2023)
- [PMID: 39973828] Exploring the mechanism of sunflower seed oil against Alzheimer's disease through experimental and network pharmacology studies — *Indian J Pharmacol* (2024)
- [PMID: 12906355] Physical behavior of purified and crude wax obtained from sunflower (Helianthus annuus) seed oil refineries and seed hulls — *Plant Foods Hum Nutr* (2003)