# GALACTOMYCES FERMENT FILTRATE (galactomyces-ferment-filtrate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/galactomyces-ferment-filtrate
- **Standard INCI**: `GALACTOMYCES FERMENT FILTRATE`
- **KR MFDS Standard Name**: `갈락토미세스발효여과물`
- **CAS No.**: `N/A`
- **EC / EINECS No.**: `N/A`
- **Origin**: `ferment`
- **Functions**: 보습제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 갈락토미세스발효여과물 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | GALACTOMYCES FERMENT FILTRATE |
| US (PCPC / MoCRA INCI) | GALACTOMYCES FERMENT FILTRATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 半乳糖酵母样菌发酵产物滤液 |
| JP (JCIA / MHLW QD) | GALACTOMYCES FERMENT FILTRATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `2374`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 94% — NMPA IECIC (2025) Entry 02412 (2025)
- **cn_iecic_max** (rinse_off): ≤ 10% — NMPA IECIC (2025) Entry 02412 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Galactomyces ferment filtrate stabilizes the actin cytoskeleton and upregulates anchoring junctions to maintain Young's modulus of keratinocytes.
This ingredient promotes keratinocyte differentiation, proliferation, and cellular bioenergetics while increasing interconnectivity between suprabasal and basal keratinocytes.
Galactomyces ferment filtrate activates the aryl hydrocarbon receptor (AHR) to upregulate IL-37 expression and subsequently downregulate IL-33 expression.
This ingredient upregulates cytochrome P450 1A1 (CYP1A1) and epidermal differentiation/barrier-related genes (SPRR1A, SPRR1B) while downregulating inflammation-related genes (CXCL14, IL6R).
Galactomyces ferment filtrate activates NRF2, the antioxidative master transcription factor, and exhibits potent antioxidative activity against oxidative stress induced by ultraviolet irradiation and proinflammatory cytokines.
This ingredient upregulates tight junction components claudin-1 and claudin-4 and wound healing-related gene serpin B2.
After 12 months of daily application, skin hydration increased and transepidermal water loss (TEWL) decreased, with significant improvement in wrinkles, pigmented spots, and roughness.
Galactomyces ferment filtrate significantly reduces daily fluctuations in facial pore area, roughness, and redness, and demonstrated efficacy in treating post-acne hyperpigmentation.

## 6. Linked PubMed Literature
- [PMID: 35663970] Natural Compounds Tapinarof and Galactomyces Ferment Filtrate Downregulate IL-33 Expression via the AHR/IL-37 Axis in Human Keratinocytes. — *Front Immunol* (2022)
- [PMID: 36012891] Transcriptomic Analysis of Human Keratinocytes Treated with Galactomyces Ferment Filtrate, a Beneficial Cosmetic Ingredient. — *J Clin Med* (2022)
- [PMID: 36769815] Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study. — *J Clin Med* (2023)
- [PMID: 33938432] The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color. — *Skinmed* (2021)
- [PMID: 40708474] Galactomyces ferment filtrate upregulates anchoring junctions and stabilizes actin to maintain the Young's modulus of skin cells in vitro — *Int J Cosmet Sci* (2026)
- [PMID: 39013659] Enhancement of skin barrier function and augmentation of epidermal cell-cell interactions by galactomyces ferment filtrate — *J Dermatol Sci* (2024)
- [PMID: 38924095] Integration of transcriptomics and spatial biology analyses reveals Galactomyces ferment filtrate promotes epidermal interconnectivity via induction of keratinocyte differentiation, proliferation and cellular bioenergetics — *Int J Cosmet Sci* (2024)
- [PMID: 35456214] Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer — *J Clin Med* (2022)
- [PMID: 31664751] Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals — *Dermatol Ther* (2019)
- [PMID: 23604963] Human keratinocyte caspase-14 expression is altered in human epidermal 3D models by dexamethasone and by natural products used in cosmetics — *Arch Dermatol Res* (2013)
- [PMID: 36362566] Galactomyces Ferment Filtrate Potentiates an Anti-Inflammaging System in Keratinocytes. — *J Clin Med* (2022)
- [PMID: 34198790] Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula — *J Clin Med* (2021)