# ETHYLHEXYLGLYCERIN (ethylhexylglycerin) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/ethylhexylglycerin - **Standard INCI**: `ETHYLHEXYLGLYCERIN` - **KR MFDS Standard Name**: `에틸헥실글리세린` - **CAS No.**: `70445-33-9` - **EC / EINECS No.**: `408-080-2` - **Origin**: `synthetic` - **Functions**: 데오도란트, 피부컨디셔닝제 - **Molecular Formula / MW**: `C11H24O3` (204.31 g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 에틸헥실글리세린 | | KR (Former Names) | 에칠헥실글리세린 | | EU (CosIng 1223/2009) | ETHYLHEXYLGLYCERIN | | US (PCPC / MoCRA INCI) | ETHYLHEXYLGLYCERIN | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 乙基己基甘油 | | JP (JCIA / MHLW QD) | エチルヘキシルグリセリン (QD: グリセリルモノ２－エチルヘキシルエーテル) | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `7706`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - **reported_use** (rinse_off): 0~8% — ethylh122011finalx.pdf (2011) - **reported_use** (eye): 0.02~1% — ethylh122011finalx.pdf (2011) - **reported_use** (ingestion): 0.08~0.5% — ethylh122011finalx.pdf (2011) - **reported_use** (spray): 0.01~2% — ethylh122011finalx.pdf (2011) - **reported_use** (powder): 0.2~0.5% — ethylh122011finalx.pdf (2011) - **reported_use** (dermal): 0.000001~8% — ethylh122011finalx.pdf (2011) - **reported_use** (deodorant): 0.04~2% — ethylh122011finalx.pdf (2011) - **reported_use** (hair): 0.0003~2% — ethylh122011finalx.pdf (2011) - **reported_use** (nail): 0.1~0.1% — ethylh122011finalx.pdf (2011) - **reported_use** (mucous): 0.000001~0.5% — ethylh122011finalx.pdf (2011) - **reported_use** (leave_on): 0.002~2% — ethylh122011finalx.pdf (2011) - **reported_use** (bath): 0.1~0.1% — ethylh122011finalx.pdf (2011) - **reported_use** (total): 0.000001~8% — ethylh122011finalx.pdf (2011) - **cn_iecic_max** (leave_on): ≤ 5% — NMPA IECIC (2025) Entry 07834 (2025) - **cn_iecic_max** (rinse_off): ≤ 2% — NMPA IECIC (2025) Entry 07834 (2025) ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 3 – 10 - **Max Process Temp**: ≤ 80°C - **Synergy Pairings**: 1,2-HEXANEDIOL, PHENOXYETHANOL, PENTYLENE GLYCOL, CAPRYLYL GLYCOL - **Incompatibilities**: Water solubility is ~0.1%; exceeding 0.1% in clear surfactant-free aqueous toners causes cloudiness unless pre-solubilized ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: ETHYLHEXYLGLYCERIN | CAS No.: 70445-33-9 | EC No.: 408-080-2 - Origin: SYNTHETIC | Functions: , - Physicochemical Profile: Formula C11H24O3 | MW 204.31 g/mol | LogP 2.4 | Ionic Nature: non-ionic | PubChem CID 98663 - Official Regional Label Names: US [ETHYLHEXYLGLYCERIN] · EU [ETHYLHEXYLGLYCERIN] · CN [乙基己基甘油] · JP [エチルヘキシルグリセリン] · JP Quasi-Drug [グリセリルモノ２－エチルヘキシルエーテル] ■ [2. Dermatological Mechanism of Action & Functional Role] - Ethylhexylglycerin is the organic compound that conforms to the formula Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 7706 (乙基己基甘油)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): cir (reported_use, rinse_off): 0~8% / cir (reported_use, eye): 0.02~1% / cir (reported_use, ingestion): 0.08~0.5% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.03 ~ 0.15% (Median 0.05%, Ref: Schülke sensiva SC 50 TDS & CIR Assessment) — Cell-membrane interfacial tension reducer & preservative booster - [emulsion_cream] Typical range: 0.03 ~ 0.3% (Median 0.08%, Ref: Schülke sensiva SC 50 / Euxyl PE 9010 TDS) — Broad-spectrum preservative booster & skin conditioning agent - [cleanser_rinse] Typical range: 0.8 ~ 1.0% (Median 1.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, SEPPIC 6 · EVONIK 1)) — Rinse-off cleanser & surfactant system modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Pre-dissolve in 1,2-Hexanediol, Butylene Glycol, or Phenoxyethanol before adding to Water/Cool-down Phase - Optimal pH Range: pH 3.0 ~ 10.0 | Max Process Temp: Max 80°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Water solubility is ~0.1%; exceeding 0.1% in clear surfactant-free aqueous toners causes cloudiness unless pre-solubilized - Synergy Pairings: 1,2-HEXANEDIOL, PHENOXYETHANOL, PENTYLENE GLYCOL, CAPRYLYL GLYCOL | Reference Trade Names: sensiva® SC 50, Euxyl® PE 9010 (90% Phenoxyethanol + 10% EHG) ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 38017612 (2024, Contact Dermatitis): A non-cosmetic allergic contact dermatitis to ethylhexylglycerin - PMID 34570737 (2022, Dermatitis): Patch Testing to Ethylhexylglycerin: The North American Contact Dermatitis Group Experience, 2013-2018 - PMID 32804659 (2020, Wounds): Synergistic Effect and Antibiofilm Activity of a Skin and Wound Cleanser ## 6. Linked PubMed Literature - [PMID: 38017612] A non-cosmetic allergic contact dermatitis to ethylhexylglycerin — *Contact Dermatitis* (2024) - [PMID: 34570737] Patch Testing to Ethylhexylglycerin: The North American Contact Dermatitis Group Experience, 2013-2018 — *Dermatitis* (2022) - [PMID: 32804659] Synergistic Effect and Antibiofilm Activity of a Skin and Wound Cleanser — *Wounds* (2020) - [PMID: 28002237] The Latest Occult "Hypoallergenic" Allergen: Ethylhexylglycerin — *Dermatitis* (2017) - [PMID: 27783695] Ethylhexylglycerin Impairs Membrane Integrity and Enhances the Lethal Effect of Phenoxyethanol — *PLoS One* (2016) - [PMID: 39153997] Deciphering trends in replacing preservatives in cosmetics intended for infants and sensitive population — *Sci Rep* (2024) - [PMID: 35256558] Natural Is Not Always Better: The Prevalence of Allergenic Ingredients in "Clean" Beauty Products — *Dermatitis* (2022) - [PMID: 34333822] In vitro study to evaluate the antimicrobial activity of various multifunctional cosmetic ingredients and chlorphenesin on bacterial species at risk in the cosmetic industry — *J Appl Microbiol* (2022) - [PMID: 33624850] Integrated approaches to testing and assessment as a tool for the hazard assessment and risk characterization of cosmetic preservatives — *J Appl Toxicol* (2021) - [PMID: 30548758] Effect of cosmetic chemical preservatives on resident flora isolated from healthy facial skin — *J Cosmet Dermatol* (2019) - [PMID: 28670452] Influence of glycerol and an alternative humectant on the immediate and 3-hours bactericidal efficacies of two isopropanol-based antiseptics in laboratory experiments in vivo according to EN 12791 — *Antimicrob Resist Infect Control* (2017) - [PMID: 27154641] Determination of alternative preservatives in cosmetic products by chromophoric derivatization followed by vortex-assisted liquid-liquid semimicroextraction and liquid chromatography — *Talanta* (2016)