# ETHYLHEXYL STEARATE (ethylhexyl-stearate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/ethylhexyl-stearate
- **Standard INCI**: `ETHYLHEXYL STEARATE`
- **KR MFDS Standard Name**: `에틸헥실스테아레이트`
- **CAS No.**: `22047-49-0`
- **EC / EINECS No.**: `244-754-0`
- **Origin**: `synthetic`
- **Functions**: 에모리엔트
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 에틸헥실스테아레이트 |
| KR (Former Names) | 에칠헥실스테아레이트 |
| EU (CosIng 1223/2009) | ETHYLHEXYL STEARATE |
| US (PCPC / MoCRA INCI) | ETHYLHEXYL STEARATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 硬脂酸乙基己酯 |
| JP (JCIA / MHLW QD) | ETHYLHEXYL STEARATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8039`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ETHYLHEXYL STEARATE | CAS No.: 22047-49-0 | EC No.: 244-754-0
  - Origin: SYNTHETIC | Functions: 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ETHYLHEXYL STEARATE] · EU [ETHYLHEXYL STEARATE] · CN [硬脂酸乙基己酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - 2-Ethylhexyl stearate Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8039 (硬脂酸乙基己酯))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.8 ~ 8.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 7)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [emulsion_cream] Typical range: 0.4 ~ 11.8% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=89, EVONIK 89)) — Emulsion cream & lotion structural / conditioning agent
  - [sun_color] Typical range: 0.8 ~ 15.5% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 5)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ETHYLHEXYL STEARATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 32788510 (2020, J Oleo Sci): Ultrasound Assisted Green Synthesis of 2-Ethylhexyl Stearate: A Cosmetic Bio-lubricant.

## 6. Linked PubMed Literature
- [PMID: 32788510] Ultrasound Assisted Green Synthesis of 2-Ethylhexyl Stearate: A Cosmetic Bio-lubricant. — *J Oleo Sci* (2020)