# ETHYLHEXYL SALICYLATE (ethylhexyl-salicylate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/ethylhexyl-salicylate
- **Standard INCI**: `ETHYLHEXYL SALICYLATE`
- **KR MFDS Standard Name**: `에칠헥실살리실레이트`
- **CAS No.**: `118-60-5`
- **EC / EINECS No.**: `204-263-4`
- **Origin**: `synthetic`
- **Functions**: 자외선차단제, 광안정제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 에칠헥실살리실레이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | ETHYLHEXYL SALICYLATE |
| US (PCPC / MoCRA INCI) | ETHYLHEXYL SALICYLATE |
| US (FDA OTC Monograph) | OCTISALATE |
| CN (NMPA IECIC) | 水杨酸乙基己酯 |
| JP (JCIA / MHLW QD) | ETHYLHEXYL SALICYLATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `restricted`
- **EU (1223/2009)**: `restricted`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `restricted` (Entry: `6413`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ETHYLHEXYL SALICYLATE | CAS No.: 118-60-5 | EC No.: 204-263-4
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ETHYLHEXYL SALICYLATE] · EU [ETHYLHEXYL SALICYLATE] · CN [水杨酸乙基己酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Ethylhexyl Salicylate is the ester of 2-ethylhexyl alcohol and salicylic acid. It conforms to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: NONE | CN: RESTRICTED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 6413 (水杨酸乙基己酯))
  - [CN / COMPOSITION / limited] (Max 5%): 
  - [CN / COMPOSITION / limited] (Max 5%): 
  - [KR / COMPOSITION / limited] (Max 5%): 
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 2.0 ~ 5.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, EVONIK 4 · ELEMENTIS 1)) — Emulsion cream & lotion structural / conditioning agent
  - [sun_color] Typical range: 1.5 ~ 5.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=47, EVONIK 27 · GRANT 15 · SEPPIC 5)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ETHYLHEXYL SALICYLATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 29981751 (2019, J Am Acad Dermatol): Review of environmental effects of oxybenzone and other sunscreen active ingredients.
  - PMID 39499337 (2024, Arch Dermatol Res): Facial disbiosis and UV filters.
  - PMID 40744385 (2025, Regul Toxicol Pharmacol): Estimates of skin and blood concentrations of UV-filters: Insights from in vitro skin experiments.

## 6. Linked PubMed Literature
- [PMID: 29981751] Review of environmental effects of oxybenzone and other sunscreen active ingredients. — *J Am Acad Dermatol* (2019)
- [PMID: 39499337] Facial disbiosis and UV filters. — *Arch Dermatol Res* (2024)
- [PMID: 40744385] Estimates of skin and blood concentrations of UV-filters: Insights from in vitro skin experiments. — *Regul Toxicol Pharmacol* (2025)
- [PMID: 42278310] Pyroptosis- and Necroptosis-Related Signaling in Salicylate UV Absorber-Induced Toxicity: Implications for Sustainable Chemistry and Human Health — *Int J Mol Sci* (2026)
- [PMID: 42084616] Laser-induced hyperspectral fluorescence for spatio-chemical detection of sunscreen contaminants in food-grade sea salt using sparse PCA-SVM analysis — *Environ Geochem Health* (2026)
- [PMID: 41518963] Occurrence of twelve UV filters and evidence of cis-octinoxate formation in Adriatic coastal waters: Environmental implications — *Mar Pollut Bull* (2026)
- [PMID: 41243163] Amended Safety Assessment of Salicylic Acid and Salicylates as Used in Cosmetics — *Int J Toxicol* (2025)
- [PMID: 41101667] Nationwide occurrence of emerging benzophenone, benzotriazole, salicylate and triazine ultraviolet filters in coastal sediment of China: Spatial distribution, source and ecological risk — *Environ Res* (2025)
- [PMID: 40782226] Marine sediments microbes degrade a limited repertoire of organic UV filters — *Environ Sci Pollut Res Int* (2025)
- [PMID: 40712201] Organic ultraviolet filters in the blubber of two free-ranging deep-diving cetacean species — *Environ Pollut* (2025)
- [PMID: 40383423] Human exposure and health risks to ultraviolet filters in personal care products marketed in China — *Environ Res* (2025)
- [PMID: 40208192] Mode of action approach supports a lack of carcinogenic potential of six organic UV filters — *Crit Rev Toxicol* (2025)
- [PMID: 40181201] Single-species tests fall short: broadening toxicity assessments of organic UV filters on marine microalgae — *Environ Toxicol Chem* (2025)
- [PMID: 40227214] Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters — *Antioxidants (Basel)* (2025)