# ETHYLHEXYL PALMITATE (ethylhexyl-palmitate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/ethylhexyl-palmitate
- **Standard INCI**: `ETHYLHEXYL PALMITATE`
- **KR MFDS Standard Name**: `에틸헥실팔미테이트`
- **CAS No.**: `29806-73-3`
- **EC / EINECS No.**: `249-862-1`
- **Origin**: `synthetic`
- **Functions**: 에모리엔트, 향료
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 에틸헥실팔미테이트 |
| KR (Former Names) | 에칠헥실팔미테이트 |
| EU (CosIng 1223/2009) | ETHYLHEXYL PALMITATE |
| US (PCPC / MoCRA INCI) | ETHYLHEXYL PALMITATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 棕榈酸乙基己酯 |
| JP (JCIA / MHLW QD) | ETHYLHEXYL PALMITATE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `8716`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ETHYLHEXYL PALMITATE | CAS No.: 29806-73-3 | EC No.: 249-862-1
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ETHYLHEXYL PALMITATE] · EU [ETHYLHEXYL PALMITATE] · CN [棕榈酸乙基己酯] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - ETHYLHEXYL PALMITATE functions primarily as ,  in dermatological and cosmetic formulations. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 8716 (棕榈酸乙基己酯))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 3.0 ~ 15.0% (Median 11.35%, Ref: Global Starter Formulation Library Statistical Distribution (n=6, SEPPIC 3 · GRANT 2 · ELEMENTIS 1)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [emulsion_cream] Typical range: 3.0 ~ 7.7% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, GRANT 5 · EVONIK 1 · SEPPIC 1)) — Emulsion cream & lotion structural / conditioning agent
  - [sun_color] Typical range: 3.0 ~ 8.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=8, GRANT 7 · ELEMENTIS 1)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ETHYLHEXYL PALMITATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 32788510 (2020, J Oleo Sci): Ultrasound Assisted Green Synthesis of 2-Ethylhexyl Stearate: A Cosmetic Bio-lubricant.
  - PMID 24256135 (2014, Skin Res Technol): Vibrational spectroscopy coupled to classical least square analysis, a new approach for determination of skin moisturizi
  - PMID 14996082 (2003, Contact Dermatitis): Compound allergy to Vea Oil

## 6. Linked PubMed Literature
- [PMID: 32788510] Ultrasound Assisted Green Synthesis of 2-Ethylhexyl Stearate: A Cosmetic Bio-lubricant. — *J Oleo Sci* (2020)
- [PMID: 24256135] Vibrational spectroscopy coupled to classical least square analysis, a new approach for determination of skin moisturizing agents' mechanisms. — *Skin Res Technol* (2014)
- [PMID: 14996082] Compound allergy to Vea Oil — *Contact Dermatitis* (2003)
- [PMID: 7286874] Monographs on fragrance raw materials — *Food Cosmet Toxicol* (1981)
- [PMID: 29152693] Synthesis of 2-Ethylhexyl Palmitate Catalyzed by Enzyme Under Microwave — *Appl Biochem Biotechnol* (2018)