# ETHYLHEXYL METHOXYCINNAMATE (ethylhexyl-methoxycinnamate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/ethylhexyl-methoxycinnamate
- **Standard INCI**: `ETHYLHEXYL METHOXYCINNAMATE`
- **KR MFDS Standard Name**: `에칠헥실메톡시신나메이트`
- **CAS No.**: `5466-77-3`
- **EC / EINECS No.**: `226-775-7`
- **Origin**: `synthetic`
- **Functions**: 자외선차단제, 광안정제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 에칠헥실메톡시신나메이트 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | ETHYLHEXYL METHOXYCINNAMATE |
| US (PCPC / MoCRA INCI) | ETHYLHEXYL METHOXYCINNAMATE |
| US (FDA OTC Monograph) | OCTINOXATE |
| CN (NMPA IECIC) | 甲氧基肉桂酸乙基己酯 |
| JP (JCIA / MHLW QD) | メトキシケイヒ酸エチルヘキシル (QD: パラメトキシケイ皮酸２－エチルヘキシル) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `restricted`
- **EU (1223/2009)**: `restricted`
- **US (FDA/MoCRA)**: `restricted`
- **CN (NMPA IECIC)**: `restricted` (Entry: `3352`)
- **JP (MHLW)**: `restricted`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **sccs_opinion** (leave_on): ≤ 10% — undefined (undefined)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: ETHYLHEXYL METHOXYCINNAMATE | CAS No.: 5466-77-3 | EC No.: 226-775-7
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [ETHYLHEXYL METHOXYCINNAMATE] · EU [ETHYLHEXYL METHOXYCINNAMATE] · CN [甲氧基肉桂酸乙基己酯] · JP [メトキシケイヒ酸エチルヘキシル] · JP Quasi-Drug [パラメトキシケイ皮酸２－エチルヘキシル]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Ethylhexyl Methoxycinnamate is the ester of 2-ethylhexyl alcohol and methoxycinnamic acid. It conforms to the formula Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: RESTRICTED | CN: RESTRICTED | JP: RESTRICTED | ASEAN: NONE (CN IECIC (2025) Entry No. 3352 (甲氧基肉桂酸乙基己酯))
  - [KR / COMPOSITION / limited] (Max 7.5%): 
  - [US / COMPOSITION / limited] (Max 7.5%): 
  - [JP / COMPOSITION / limited] (Max 20%): 
  - Official Safety & Historical Use Concentration (Layer 2): sccs (sccs_opinion, leave_on): Max 10%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [sun_color] Typical range: 2.0 ~ 10.0% (Median 6.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=28, GRANT 12 · EVONIK 8 · SEPPIC 6 · ELEMENTIS 2)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: ETHYLHEXYL METHOXYCINNAMATE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 42084616 (2026, Environ Geochem Health): Laser-induced hyperspectral fluorescence for spatio-chemical detection of sunscreen contaminants in food-grade sea salt 
  - PMID 41985167 (2026, Cutan Ocul Toxicol): Leveraging a TRPV1-overexpressing cell model: an integrated testing strategy for UV filter-induced ocular irritation
  - PMID 41915798 (2026, JMIR Res Protoc): Occupational Exposure to Resorcinol and Thyroid-Disrupting Effects: Protocol for an Exploratory Field Study in French Ha

## 6. Linked PubMed Literature
- [PMID: 42084616] Laser-induced hyperspectral fluorescence for spatio-chemical detection of sunscreen contaminants in food-grade sea salt using sparse PCA-SVM analysis — *Environ Geochem Health* (2026)
- [PMID: 41985167] Leveraging a TRPV1-overexpressing cell model: an integrated testing strategy for UV filter-induced ocular irritation — *Cutan Ocul Toxicol* (2026)
- [PMID: 41915798] Occupational Exposure to Resorcinol and Thyroid-Disrupting Effects: Protocol for an Exploratory Field Study in French Hairdressers — *JMIR Res Protoc* (2026)
- [PMID: 41548346] First evidence of climate-driven modulation of octinoxate toxicity in the sea urchin Paracentrotus lividus — *Mar Environ Res* (2026)
- [PMID: 41518963] Occurrence of twelve UV filters and evidence of cis-octinoxate formation in Adriatic coastal waters: Environmental implications — *Mar Pollut Bull* (2026)
- [PMID: 41151436] Polyphenol-rich green propolis extract improves antioxidant and UV protection in sunscreen formulations — *J Photochem Photobiol B* (2025)
- [PMID: 41058610] Environmental hazard ingredients in women's hair growth cosmeceuticals: a comprehensive analysis — *Int J Womens Dermatol* (2025)
- [PMID: 40651348] Hidden costs of beauty: An in vitro study on the ecotoxicological impacts of ultraviolet filters and parabens on the bioindicator species Mytilus galloprovincialis — *Mar Pollut Bull* (2025)
- [PMID: 40614422] The invisible threats of sunscreen as a plastic co-pollutant: Impact of a common organic UV filter on biofilm formation and metabolic function in the nascent marine plastisphere — *J Hazard Mater* (2025)
- [PMID: 40383423] Human exposure and health risks to ultraviolet filters in personal care products marketed in China — *Environ Res* (2025)
- [PMID: 41908471] Ultrafast Spectroscopy of Commercial Sunscreen Formulations in Thin Films and on a Skin Mimic — *ACS Omega* (2026)
- [PMID: 40227214] Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters — *Antioxidants (Basel)* (2025)