# DIPOTASSIUM GLYCYRRHIZATE (dipotassium-glycyrrhizate) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/dipotassium-glycyrrhizate
- **Standard INCI**: `DIPOTASSIUM GLYCYRRHIZATE`
- **KR MFDS Standard Name**: `다이포타슘글리시리제이트`
- **CAS No.**: `68797-35-3`
- **EC / EINECS No.**: `272-296-1`
- **Origin**: `synthetic`
- **Functions**: 보습제, 피부컨디셔닝제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 다이포타슘글리시리제이트 |
| KR (Former Names) | 디포타슘글리시리제이트 |
| EU (CosIng 1223/2009) | DIPOTASSIUM GLYCYRRHIZATE |
| US (PCPC / MoCRA INCI) | DIPOTASSIUM GLYCYRRHIZATE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 甘草酸二钾 |
| JP (JCIA / MHLW QD) | グリチルリチン酸２Ｋ (QD: グリチルリチン酸ジカリウム) |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `2397`)
- **JP (MHLW)**: `restricted`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 2% — NMPA IECIC (2025) Entry 02455 (2025)
- **cn_iecic_max** (rinse_off): ≤ 1% — NMPA IECIC (2025) Entry 02455 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4.5 – 7.5
- **Max Process Temp**: ≤ 70°C
- **Synergy Pairings**: —
- **Incompatibilities**: —

## 5. Academic Monograph
Dipotassium glycyrrhizate is a potassium salt of glycyrrhizic acid derived from licorice plants and is used in cosmetics as a skin-conditioning agent.
This ingredient demonstrated skin hydration capacity, increasing stratum corneum hydration by 74.1% from baseline and reducing transepidermal water loss (TEWL) by 13.5% in a 28-day clinical trial.
It exhibits anti-inflammatory effects, contributing to alleviation of skin irritation and modulation of the inflammatory microenvironment, with improvements in erythema, tightness, dryness, and scaliness observed post-photorejuvenation.
It possesses antimicrobial activity, demonstrating antibacterial action against Staphylococcus aureus.
It promotes wound healing effects, showing rapid wound closure, efficient tissue remodeling, increased collagen deposition, and decreased inflammation in a full-thickness skin defect animal model.
In diabetic wound healing, it demonstrated synergistic antioxidant interactions, accelerating wound healing through CD31 upregulation (promoting microvascular formation) and cytokine modulation (increased IL-10, decreased TNF-α).
Its transepidermal permeability through skin is very low (undetectable in transepidermal permeation testing through pig skin), demonstrating excellent skin safety with no signs of irritation or discomfort observed.

## 6. Linked PubMed Literature
- [PMID: 42108609] Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial — *J Cosmet Dermatol* (2026)
- [PMID: 42056802] A upper critical solution temperature- and synergistic antioxidant-responsive tremella polysaccharide hydrogel for enhancing diabetic wound healing — *Biomater Adv* (2026)
- [PMID: 40957858] A Split-Face Randomized Study on the Efficacy of a Platinum-Liposome-Based Facial Mask Containing Soothing Ingredients for Post-Photorejuvenation Skin Recovery — *J Cosmet Dermatol* (2025)
- [PMID: 35245682] Injectable thermo-sensitive and wide-crack self-healing hydrogel loaded with antibacterial anti-inflammatory dipotassium glycyrrhizate for full-thickness skin wound repair — *Acta Biomater* (2022)
- [PMID: 34087055] An open-label, investigator-initiated, single-center, prospective, pilot clinical study to evaluate the efficacy of a skin whitening serum applied twice daily combined with a spot-preventing SPF50+ sunscreen in healthy female subjects with melasma hyperpigmentation — *J Cosmet Dermatol* (2022)
- [PMID: 28915283] Clinical Evaluation of a Multi-Modal Facial Serum That Addresses Hyaluronic Acid Levels in Skin — *J Drugs Dermatol* (2017)
- [PMID: 28612442] Allergic contact dermatitis caused by arbutin and dipotassium glycyrrhizate in skin-lightening products — *Contact Dermatitis* (2017)
- [PMID: 17613133] Final report on the safety assessment of Glycyrrhetinic Acid, Potassium Glycyrrhetinate, Disodium Succinoyl Glycyrrhetinate, Glyceryl Glycyrrhetinate, Glycyrrhetinyl Stearate, Stearyl Glycyrrhetinate, Glycyrrhizic Acid, Ammonium Glycyrrhizate, Dipotassium Glycyrrhizate, Disodium Glycyrrhizate, Trisodium Glycyrrhizate, Methyl Glycyrrhizate, and Potassium Glycyrrhizinate — *Int J Toxicol* (2007)