# DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE (diethylamino-hydroxybenzoyl-hexyl-benzoate) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/diethylamino-hydroxybenzoyl-hexyl-benzoate - **Standard INCI**: `DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE` - **KR MFDS Standard Name**: `디에칠아미노하이드록시벤조일헥실벤조에이트` - **CAS No.**: `302776-68-7` - **EC / EINECS No.**: `443-860-6` - **Origin**: `synthetic` - **Functions**: 자외선차단제, 광안정제 - **Molecular Formula / MW**: `—` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 디에칠아미노하이드록시벤조일헥실벤조에이트 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE | | US (PCPC / MoCRA INCI) | DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE | | US (FDA OTC Monograph) | DHHB (UNAPPROVED OTC IN US) | | CN (NMPA IECIC) | 二乙氨羟苯甲酰基苯甲酸己酯 | | JP (JCIA / MHLW QD) | DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `restricted` - **EU (1223/2009)**: `restricted` - **US (FDA/MoCRA)**: `banned` - **CN (NMPA IECIC)**: `restricted` (Entry: `2217`) - **JP (MHLW)**: `restricted` - **ASEAN (ACD)**: `restricted` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - Listed within general cosmetic GMP safety thresholds. ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 4 – 8 - **Max Process Temp**: ≤ 50°C - **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL - **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE | CAS No.: 302776-68-7 | EC No.: 443-860-6 - Origin: SYNTHETIC | Functions: , - Physicochemical Profile: Formula | MW /(Polymer/Complex) | / | Ionic Nature: non-ionic | CosIng/MFDS - Official Regional Label Names: US [DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE] · EU [DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE] · CN [二乙氨羟苯甲酰基苯甲酸己酯] · JP [-] · JP Quasi-Drug [-] ■ [2. Dermatological Mechanism of Action & Functional Role] - Diethylamino Hydroxybenzoyl Hexyl Benzoate is the organic compound that conforms to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: BANNED | CN: RESTRICTED | JP: RESTRICTED | ASEAN: RESTRICTED (CN IECIC (2025) Entry No. 2217 (二乙氨羟苯甲酰基苯甲酸己酯)) - [CN / COMPOSITION / limited] (Max 10%): - [KR / COMPOSITION / limited] (Max 10%): - [CN / COMPOSITION / limited] (Max 10%): - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [sun_color] Typical range: 1.0 ~ 10.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=22, EVONIK 22)) — Sun care & color cosmetics dispersion / sensory modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase or Cool-down Phase (< 45°C) - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: DIETHYLAMINO HYDROXYBENZOYL HEXYL BENZOATE ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 42197211 (2026, Molecules): Organic Sunscreens-Biological Activity from an Enzymatic Perspective - PMID 41967699 (2026, J Invest Dermatol): M10, a bioadhesive UV filter with enhanced and long-lasting photoprotection - PMID 41411795 (2026, Ecotoxicol Environ Saf): Acute toxicity of novel triazine-based UV filters towards Chlorella vulgaris and Daphnia magna: Single and mixture effec ## 6. Linked PubMed Literature - [PMID: 42197211] Organic Sunscreens-Biological Activity from an Enzymatic Perspective — *Molecules* (2026) - [PMID: 41967699] M10, a bioadhesive UV filter with enhanced and long-lasting photoprotection — *J Invest Dermatol* (2026) - [PMID: 41411795] Acute toxicity of novel triazine-based UV filters towards Chlorella vulgaris and Daphnia magna: Single and mixture effect — *Ecotoxicol Environ Saf* (2026) - [PMID: 40931463] New alternatives in photoprotection: Preparation and evaluation of lamellar silicate derivatives and their use as sunscreens — *Int J Cosmet Sci* (2026) - [PMID: 40782226] Marine sediments microbes degrade a limited repertoire of organic UV filters — *Environ Sci Pollut Res Int* (2025) - [PMID: 40117958] Assessing the exposure to the UV filter DHHB in urine samples from the German Environmental Specimen Bank (2000-2021): Evaluating the impact of a potential impurity of di-n-hexyl phthalate in DHHB — *Int J Hyg Environ Health* (2025) - [PMID: 39853158] Use of Propolis and Echinacea extracts as alternatives to organic filter in photoprotective formulations — *Nat Prod Res* (2026) - [PMID: 39824136] Targeted and untargeted discovery of UV filters and emerging contaminants with environmental risk assessment on the Northwestern Mediterranean coast — *Mar Pollut Bull* (2025) - [PMID: 39596438] Organic Sunscreens and Their Products of Degradation in Biotic and Abiotic Conditions-In Silico Studies of Drug-Likeness and Human Placental Transport — *Int J Mol Sci* (2024) - [PMID: 38703981] Inorganic UV filter-based sunscreens labelled as eco-friendly threaten sea urchin populations — *Environ Pollut* (2024) - [PMID: 38010544] Microbial consortia degrade several widely used organic UV filters, but a number of hydrophobic filters remain recalcitrant to biodegradation — *Environ Sci Pollut Res Int* (2023) - [PMID: 41730063] Sunscreens — *PubMed Journal* (2006)