# DECYL GLUCOSIDE (decyl-glucoside) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/decyl-glucoside
- **Standard INCI**: `DECYL GLUCOSIDE`
- **KR MFDS Standard Name**: `데실글루코사이드`
- **CAS No.**: `54549-25-6`
- **EC / EINECS No.**: `259-218-1`
- **Origin**: `synthetic`
- **Functions**: 세정제, 유화안정제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 데실글루코사이드 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | DECYL GLUCOSIDE |
| US (PCPC / MoCRA INCI) | DECYL GLUCOSIDE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 癸基葡糖苷 |
| JP (JCIA / MHLW QD) | DECYL GLUCOSIDE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `2687`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: DECYL GLUCOSIDE | CAS No.: 54549-25-6 | EC No.: 259-218-1
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [DECYL GLUCOSIDE] · EU [DECYL GLUCOSIDE] · CN [癸基葡糖苷] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Decyl Glucoside is the product obtained from the condensation of decyl alcohol with glucose Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 2687 (癸基葡糖苷))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [aqueous_serum] Typical range: 0.1 ~ 0.2% (Median 0.1%, Ref: Global Starter Formulation Library Statistical Distribution (n=14, GRANT 14)) — Aqueous serum, toner & hydrogel matrix formulation component
  - [cleanser_rinse] Typical range: 1.0 ~ 15.0% (Median 7.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=13, SEPPIC 12 · EVONIK 1)) — Rinse-off cleanser & surfactant system modifier
  - [emulsion_cream] Typical range: 0.1 ~ 5.0% (Median 0.2%, Ref: Global Starter Formulation Library Statistical Distribution (n=16, GRANT 16)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: DECYL GLUCOSIDE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 42289776 (2026, Contact Dermatitis): Alkyl Glucosides in Rinse-Off and Leave-On Cosmetics Available on the Dutch Market
  - PMID 41707668 (2026, Contact Dermatitis): Allergic Contact Dermatitis to Alkyl Glucosides: Becoming More Relevant in Facial Dermatitis?
  - PMID 41503492 (2026, RSC Adv): Decyl glucoside as a sustainable surfactant for cosmetic formulations: environmental stability under hardness, pH, and t

## 6. Linked PubMed Literature
- [PMID: 42289776] Alkyl Glucosides in Rinse-Off and Leave-On Cosmetics Available on the Dutch Market — *Contact Dermatitis* (2026)
- [PMID: 41707668] Allergic Contact Dermatitis to Alkyl Glucosides: Becoming More Relevant in Facial Dermatitis? — *Contact Dermatitis* (2026)
- [PMID: 41503492] Decyl glucoside as a sustainable surfactant for cosmetic formulations: environmental stability under hardness, pH, and temperature variations — *RSC Adv* (2026)
- [PMID: 41184211] Contact Allergy to Preservatives and Emulsifiers in Patients With or Without Atopic Dermatitis — *Contact Dermatitis* (2026)
- [PMID: 41011709] Application of Alkyl Polyglucosides as Components of the Extraction Medium in the Preparation of a Shampoo Cosmetic Formulation Containing Substances Isolated from Red Grape Pomace — *Molecules* (2025)
- [PMID: 40394829] Frequent Positive Patch Test Reactions to Glucosides in Children: A Call for Caution? — *Contact Dermatitis* (2025)
- [PMID: 36305668] Use of sorbitan sesquioleate in patch test preparations and patch testing with the substance-What do our results mean? — *Contact Dermatitis* (2023)
- [PMID: 36268749] Co-reactivity of glucosides: Retrospective analysis of North American Contact Dermatitis Group Data 2019-2020 — *Contact Dermatitis* (2023)
- [PMID: 35551968] Patch testing with glucosides: The North American Contact Dermatitis Group experience, 2009-2018 — *J Am Acad Dermatol* (2022)
- [PMID: 35099073] European patch test results with audit allergens as candidates for inclusion in the European Baseline Series, 2019/20: Joint results of the ESSCA(A) and the EBS(B) working groups of the ESCD, and the GEIDAC(C) — *Contact Dermatitis* (2022)
- [PMID: 34524773] The History of Surfactants and Review of Their Allergic and Irritant Properties — *Dermatitis* (2021)
- [PMID: 41471714] Extracts from By-Products of the Fruit and Vegetable Industry as Ingredients Improving the Properties of Cleansing Gels — *Molecules* (2025)