# CI 77499 (ci-77499) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/ci-77499
- **Standard INCI**: `CI 77499`
- **KR MFDS Standard Name**: `흑색산화철`
- **CAS No.**: `12227-89-3`
- **EC / EINECS No.**: `235-442-5`
- **Origin**: `mineral`
- **Functions**: 색소
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 흑색산화철 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | CI 77499 |
| US (PCPC / MoCRA INCI) | IRON OXIDES |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | CI 77499 |
| JP (JCIA / MHLW QD) | CI 77499  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `allowed`
- **EU (1223/2009)**: `noted`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `369`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `restricted`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: CI 77499 | CAS No.: 12227-89-3 | EC No.: 235-442-5
  - Origin: MINERAL | Functions: 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [IRON OXIDES] · EU [CI 77499] · CN [CI 77499] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - CI 77499 is classed chemically as an inorganic colour. It consists chiefly of ferrous-ferric oxide (see also INCI:Iron Oxides) Classified under origin 'mineral', it acts within the cosmetic vehicle or stratum corneum to deliver  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: ALLOWED | EU: NOTED | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: RESTRICTED (CN IECIC (2025) Entry No. 369 (CI 77499))
  - [EU / COMPOSITION / noted]: 
  - [EU / COMPOSITION / noted]: 
  - [EU / COMPOSITION / noted]: 
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [sun_color] Typical range: 0.02 ~ 10.0% (Median 0.08%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 7)) — Sun care & color cosmetics dispersion / sensory modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: CI 77499
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - Validated against official regulatory compendia (MFDS/CosIng/CIR/SCCS) and physicochemical standards.

## 6. Linked PubMed Literature