# CETRIMONIUM CHLORIDE (cetrimonium-chloride) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/cetrimonium-chloride
- **Standard INCI**: `CETRIMONIUM CHLORIDE`
- **KR MFDS Standard Name**: `세트리모늄클로라이드`
- **CAS No.**: `112-02-7`
- **EC / EINECS No.**: `203-928-6`
- **Origin**: `synthetic`
- **Functions**: 항균제, 대전방지제, 방부제, 유화제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 세트리모늄클로라이드 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | CETRIMONIUM CHLORIDE |
| US (PCPC / MoCRA INCI) | CETRIMONIUM CHLORIDE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 西曲氯铵 |
| JP (JCIA / MHLW QD) | CETRIMONIUM CHLORIDE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `restricted`
- **EU (1223/2009)**: `restricted`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `6886`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **reported_use** (hair_dye): 0.3~0.3% — 115_draft_trimon.pdf (null)
- **reported_use** (leave_on): 0.1~0.1% — 115_draft_trimon.pdf (null)
- **reported_use** (rinse_off): 0.08~3% — 115_draft_trimon.pdf (null)
- **sccs_opinion** (rinse_off): ≤ 2.5% — undefined (undefined)
- **sccs_opinion** (leave_on): ≤ 1% — undefined (undefined)
- **sccs_opinion** (face_cream): ≤ 0.5% — undefined (undefined)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: CETRIMONIUM CHLORIDE | CAS No.: 112-02-7 | EC No.: 203-928-6
  - Origin: SYNTHETIC | Functions: , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [CETRIMONIUM CHLORIDE] · EU [CETRIMONIUM CHLORIDE] · CN [西曲氯铵] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Cetrimonium Chloride is a quaternary ammonium salt that conforms generally to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: RESTRICTED | EU: RESTRICTED | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 6886 (西曲氯铵))
  - [EU / COMPOSITION / limited] (Max 0.1%): 
  - [EU / COMPOSITION / limited] (Max 2.5%): 
  - [KR / COMPOSITION / limited] (Max 2.5%): 
  - Official Safety & Historical Use Concentration (Layer 2): cir (reported_use, hair_dye): 0.3~0.3% / cir (reported_use, leave_on): 0.1~0.1% / cir (reported_use, rinse_off): 0.08~3%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [cleanser_rinse] Typical range: 1.3 ~ 8.33% (Median 3.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, EVONIK 5 · GRANT 1 · SEPPIC 1)) — Rinse-off cleanser & surfactant system modifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: CETRIMONIUM CHLORIDE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 37409071 (2023, Clin Cosmet Investig Dermatol): Quaternary Ammonium Compounds and Contact Dermatitis: A Review and Considerations During the COVID-19 Pandemic
  - PMID 19889043 (2010, Int J Cosmet Sci): Simple and rapid analytical method for the simultaneous determination of cetrimonium chloride and alkyl alcohols in hair
  - PMID 38320244 (2024, Dermatitis): Allergic or Not: Final Interpretation of Doubtful Patch Test Reactions From the North American Contact Dermatitis Group,

## 6. Linked PubMed Literature
- [PMID: 37409071] Quaternary Ammonium Compounds and Contact Dermatitis: A Review and Considerations During the COVID-19 Pandemic — *Clin Cosmet Investig Dermatol* (2023)
- [PMID: 19889043] Simple and rapid analytical method for the simultaneous determination of cetrimonium chloride and alkyl alcohols in hair conditioners — *Int J Cosmet Sci* (2010)
- [PMID: 38320244] Allergic or Not: Final Interpretation of Doubtful Patch Test Reactions From the North American Contact Dermatitis Group, 2019-2020 — *Dermatitis* (2024)
- [PMID: 30094863] Allergic contact dermatitis secondary to the use of a bandage impregnated with benzalkonium chloride — *Contact Dermatitis* (2018)
- [PMID: 9561834] Histopathological effects of topical ophthalmic preservatives on rat corneoconjunctival surface — *Curr Eye Res* (1998)
- [PMID: 7959096] The effect of preservatives and antiglaucomatous medication on the histopathology of the conjunctiva — *Graefes Arch Clin Exp Ophthalmol* (1994)
- [PMID: 42119435] MPF-mediated anion-π(+) interaction for high-efficiency aggregation-induced electrochemiluminescence system: application in trace cetrimonium chloride analysis — *Talanta* (2026)