# CETEARYL GLUCOSIDE (cetearyl-glucoside) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/cetearyl-glucoside
- **Standard INCI**: `CETEARYL GLUCOSIDE`
- **KR MFDS Standard Name**: `세테아릴글루코사이드`
- **CAS No.**: `246159-33-1`
- **EC / EINECS No.**: `N/A`
- **Origin**: `synthetic`
- **Functions**: 유화제, 세정제
- **Molecular Formula / MW**: `C28H56O7` (546.7 g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 세테아릴글루코사이드 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | CETEARYL GLUCOSIDE |
| US (PCPC / MoCRA INCI) | CETEARYL GLUCOSIDE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 鲸蜡硬脂基葡糖苷 |
| JP (JCIA / MHLW QD) | CETEARYL GLUCOSIDE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `3636`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- **cn_iecic_max** (leave_on): ≤ 5% — NMPA IECIC (2025) Entry 03508 (2025)
- **cn_iecic_max** (rinse_off): ≤ 3% — NMPA IECIC (2025) Entry 03508 (2025)

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 3 – 10
- **Max Process Temp**: ≤ 85°C
- **Synergy Pairings**: CETEARYL ALCOHOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, SQUALANE, XANTHAN GUM
- **Incompatibilities**: Requires emulsification temperature ≥ 75°C to fully melt cetearyl alcohol co-crystals

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: CETEARYL GLUCOSIDE | CAS No.: 246159-33-1 | EC No.: N/A
  - Origin: SYNTHETIC | Functions: , 
  - Physicochemical Profile: Formula C28H56O7 | MW 546.7 g/mol | /   | Ionic Nature: non-ionic | PubChem CID 6452086
  - Official Regional Label Names: US [CETEARYL GLUCOSIDE] · EU [CETEARYL GLUCOSIDE] · CN [鲸蜡硬脂基葡糖苷] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - D-Glucopyranose, C16-18 alkyl glycosides Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 3636 (鲸蜡硬脂基葡糖苷))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 5.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 3.0%
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 1.0 ~ 5.0% (Median 2.5%, Ref: SEPPIC MONTANOV 68 TDS & Formulation Library) — COSMOS-approved alkylpolyglucoside lamellar emulsifier
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Oil Phase (Heat to 75~80°C with Cetearyl Alcohol)
  - Optimal pH Range: pH 3.0 ~ 10.0 | Max Process Temp: Max 85°C | Electrolyte Tolerance: HIGH
  - Incompatibility / Caution: Requires emulsification temperature ≥ 75°C to fully melt cetearyl alcohol co-crystals
  - Synergy Pairings: CETEARYL ALCOHOL, CAPRYLIC/CAPRIC TRIGLYCERIDE, SQUALANE, XANTHAN GUM | Reference Trade Names: MONTANOV™ 68, TEGO® Care CG 90
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 42289776 (2026, Contact Dermatitis): Alkyl Glucosides in Rinse-Off and Leave-On Cosmetics Available on the Dutch Market
  - PMID 41707668 (2026, Contact Dermatitis): Allergic Contact Dermatitis to Alkyl Glucosides: Becoming More Relevant in Facial Dermatitis?
  - PMID 36268749 (2023, Contact Dermatitis): Co-reactivity of glucosides: Retrospective analysis of North American Contact Dermatitis Group Data 2019-2020

## 6. Linked PubMed Literature
- [PMID: 42289776] Alkyl Glucosides in Rinse-Off and Leave-On Cosmetics Available on the Dutch Market — *Contact Dermatitis* (2026)
- [PMID: 41707668] Allergic Contact Dermatitis to Alkyl Glucosides: Becoming More Relevant in Facial Dermatitis? — *Contact Dermatitis* (2026)
- [PMID: 36268749] Co-reactivity of glucosides: Retrospective analysis of North American Contact Dermatitis Group Data 2019-2020 — *Contact Dermatitis* (2023)
- [PMID: 34628676] Allergic contact dermatitis in response to cetearyl glucoside from a topical drug — *Contact Dermatitis* (2022)
- [PMID: 30460735] Patch testing with alkyl glucosides: Concomitant reactions are common but not ubiquitous — *Contact Dermatitis* (2019)
- [PMID: 24588370] Allergic contact dermatitis caused by alkyl glucosides — *Contact Dermatitis* (2014)
- [PMID: 24127836] Application of D-optimal experimental design method to optimize the formulation of O/W cosmetic emulsions — *Int J Cosmet Sci* (2014)
- [PMID: 23688275] Development of a prospective isopropyl alcohol-loaded pharmaceutical base using simultaneous in vitro/in vivo characterization methods of skin performance — *Drug Dev Ind Pharm* (2014)
- [PMID: 20523109] Interaction of epicutaneously applied lipids with stratum corneum depends on the presence of either emulsifiers or hydrogenated phosphatidylcholine — *Skin Pharmacol Physiol* (2010)
- [PMID: 19616085] Natural surfactant-based topical vehicles for two model drugs: Influence of different lipophilic excipients on in vitro/in vivo skin performance — *Int J Pharm* (2009)
- [PMID: 18937361] Topical vehicles based on natural surfactant/fatty alcohols mixed emulsifier: The influence of two polyols on the colloidal structure and in vitro/in vivo skin performance — *J Pharm Sci* (2009)
- [PMID: 18377631] In vitro skin permeation of sunscreen agents from O/W emulsions — *Int J Cosmet Sci* (2008)