# CARBOMER (carbomer) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/carbomer - **Standard INCI**: `CARBOMER` - **KR MFDS Standard Name**: `카보머` - **CAS No.**: `9003-01-4` - **EC / EINECS No.**: `N/A` - **Origin**: `synthetic` - **Functions**: 점도조절제, 유화안정제, 겔형성제 - **Molecular Formula / MW**: `(C3H4O2)n` (— g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 카보머 | | KR (Former Names) | — | | EU (CosIng 1223/2009) | CARBOMER | | US (PCPC / MoCRA INCI) | CARBOMER | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 卡波姆 | | JP (JCIA / MHLW QD) | カルボマー (QD: カルボキシビニルポリマー) | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `4079`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - **cn_iecic_max** (leave_on): ≤ 3% — NMPA IECIC (2025) Entry 03692 (2025) - **cn_iecic_max** (rinse_off): ≤ 2.5% — NMPA IECIC (2025) Entry 03692 (2025) ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 5.5 – 9 - **Max Process Temp**: ≤ 75°C - **Synergy Pairings**: ARGININE, TROMETHAMINE, XANTHAN GUM, POLYACRYLATE CROSSPOLYMER-6 - **Incompatibilities**: Immediate viscosity collapse upon addition of mono-/divalent electrolytes (NaCl, SAP, Zinc PCA) or strong acids; Insoluble complex precipitation with cationic surfactants/polymers and Copper Tripeptide-1 (GHK-Cu) ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: CARBOMER | CAS No.: 9003-01-4 | EC No.: N/A - Origin: SYNTHETIC | Functions: , , - Physicochemical Profile: Formula (C3H4O2)n | MW /(Polymer/Complex) | / | Ionic Nature: anionic | PubChem CID 6581 - Official Regional Label Names: US [CARBOMER] · EU [CARBOMER] · CN [卡波姆] · JP [カルボマー] · JP Quasi-Drug [カルボキシビニルポリマー] ■ [2. Dermatological Mechanism of Action & Functional Role] - 2-Propenoic acid, polymer with 2,2-bis(hydroxymethyl)propane-1,3-diol 2-propenyl ether Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 4079 (卡波姆)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 3.0% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 2.5% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [aqueous_serum] Typical range: 0.05 ~ 1.0% (Median 0.25%, Ref: Lubrizol Carbopol TDS-730 & CIR Safety Assessment) — Primary aqueous gel thickener & yield value modifier - [emulsion_cream] Typical range: 0.05 ~ 0.8% (Median 0.2%, Ref: Lubrizol Carbopol TDS & CIR Reported Use) — O/W emulsion viscosity builder & aqueous phase stabilizer - [sun_color] Typical range: 0.1 ~ 2.4% (Median 0.3%, Ref: Global Starter Formulation Library Statistical Distribution (n=5, GRANT 4 · ELEMENTIS 1)) — Sun care & color cosmetics dispersion / sensory modifier ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Water Phase (Pre-dispersion -> Neutralization with Arginine/Tromethamine/KOH) - Optimal pH Range: pH 5.5 ~ 9.0 | Max Process Temp: Max 75°C | Electrolyte Tolerance: NONE - Incompatibility / Caution: Immediate viscosity collapse upon addition of mono-/divalent electrolytes (NaCl, SAP, Zinc PCA) or strong acids - Incompatibility / Caution: Insoluble complex precipitation with cationic surfactants/polymers and Copper Tripeptide-1 (GHK-Cu) - Synergy Pairings: ARGININE, TROMETHAMINE, XANTHAN GUM, POLYACRYLATE CROSSPOLYMER-6 | Reference Trade Names: Carbopol® 940, Carbopol® 980, Carbopol® Ultrez 10, Carbopol® Ultrez 21 ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 42042166 (2026, Gels): Ameliorative Effects of Liquiritin Carbomer Gel on Dinitrofluorobenzene-Induced Atopic Dermatitis in Mice - PMID 41782005 (2026, J Nanobiotechnology): Correction: Multifunctional carbomer based ferulic acid hydrogel promotes wound healing in radiation-induced skin injury - PMID 42283162 (2026, Curr Protoc): Enhancing Biological Activity in Skin Repair with a Transdermal Peptide-Recombinant Type III Collagen Hydrogel ## 6. Linked PubMed Literature - [PMID: 42042166] Ameliorative Effects of Liquiritin Carbomer Gel on Dinitrofluorobenzene-Induced Atopic Dermatitis in Mice — *Gels* (2026) - [PMID: 41782005] Correction: Multifunctional carbomer based ferulic acid hydrogel promotes wound healing in radiation-induced skin injury by inactivating NLRP3 inflammasome — *J Nanobiotechnology* (2026) - [PMID: 42283162] Enhancing Biological Activity in Skin Repair with a Transdermal Peptide-Recombinant Type III Collagen Hydrogel — *Curr Protoc* (2026) - [PMID: 42280282] Structure and Wound-Healing Activity of a Branched Levan-Type Fructan from Cyathula officinalis Roots — *Molecules* (2026) - [PMID: 42197147] Development, Physicochemical Characterization, and Biological Activity of a Gel Based on Iris scariosa L. Extract — *Molecules* (2026) - [PMID: 42027906] Preparation and Optimization of Voriconazole Gel 0.25% for Topical Delivery in Terbinafine Resistance Dermatophytosis: In Vitro and Pilot Animal Study — *Dermatol Res Pract* (2026) - [PMID: 42019729] Plastic in dermatology: Impacts on human health, skin disease, and the contribution of personal care product use to environmental pollution — *J Am Acad Dermatol* (2026) - [PMID: 41752207] Perillaldehyde-Encapsulated Lipid Nanoparticle Hydrogel for Enhanced Wound Healing, Improved Stability and Biocompatibility — *Int J Mol Sci* (2026) - [PMID: 41699719] Polymeric micelle hydrogel of Resina Draconis enables mechanistically targeted protection against skin photoaging — *Chin Med* (2026) - [PMID: 41687221] Multifunctional natural herbal extracts Lamiophlomis rotata (Benth.) Kudo composite gel for infected wounds healing — *Colloids Surf B Biointerfaces* (2026) - [PMID: 41649609] Formulation and evaluation of amphotericin B emulsion gel against Leishmania major in a murine model: parasite burden, gene expression, and histopathological profiling — *Parasitol Res* (2026) - [PMID: 41623201] Clinical Outcomes Following Diamond Burr Debridement of Spontaneous Chronic Corneal Epithelial Defects: A Retrospective Study of 521 Dogs — *Vet Ophthalmol* (2026)