# CAPRYLOYL GLYCINE (capryloyl-glycine) — Global Cosmetic Regulatory & Formulation Monograph

- **Canonical URL**: https://www.inciname.com/en/ingredients/capryloyl-glycine
- **Standard INCI**: `CAPRYLOYL GLYCINE`
- **KR MFDS Standard Name**: `카프릴로일글라이신`
- **CAS No.**: `14246-53-8`
- **EC / EINECS No.**: `238-122-3`
- **Origin**: `synthetic`
- **Functions**: 피지억제제, 항균제, 데오도란트, 모발컨디셔닝제, 세정제
- **Molecular Formula / MW**: `—` (— g/mol)

## 1. 7-Track Official Regulatory Label Names
| Track | Official Label Nomenclature |
| :--- | :--- |
| KR (MFDS Standard) | 카프릴로일글라이신 |
| KR (Former Names) | — |
| EU (CosIng 1223/2009) | CAPRYLOYL GLYCINE |
| US (PCPC / MoCRA INCI) | CAPRYLOYL GLYCINE |
| US (FDA OTC Monograph) | — |
| CN (NMPA IECIC) | 辛酰甘氨酸 |
| JP (JCIA / MHLW QD) | CAPRYLOYL GLYCINE  |

## 2. Layer 1 — Global 6-Region Statutory Summary
- **KR (MFDS)**: `none`
- **EU (1223/2009)**: `none`
- **US (FDA/MoCRA)**: `none`
- **CN (NMPA IECIC)**: `allowed` (Entry: `7215`)
- **JP (MHLW)**: `none`
- **ASEAN (ACD)**: `none`



## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations
- Listed within general cosmetic GMP safety thresholds.

## 4. Layer 3 — Formulation Quartiles & Compatibility
- **Optimal pH Window**: 4 – 8
- **Max Process Temp**: ≤ 50°C
- **Synergy Pairings**: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL
- **Incompatibilities**: Verify phase compatibility under extreme pH or high electrolyte loads

## 5. Academic Monograph
■ [1. Chemical Identity & International Labeling Nomenclature]
  - INCI Name: CAPRYLOYL GLYCINE | CAS No.: 14246-53-8 | EC No.: 238-122-3
  - Origin: SYNTHETIC | Functions: , , , , 
  - Physicochemical Profile: Formula      | MW /(Polymer/Complex) | /   | Ionic Nature: non-ionic | CosIng/MFDS 
  - Official Regional Label Names: US [CAPRYLOYL GLYCINE] · EU [CAPRYLOYL GLYCINE] · CN [辛酰甘氨酸] · JP [-] · JP Quasi-Drug [-]
■ [2. Dermatological Mechanism of Action & Functional Role]
  - Capryloyl Glycine is the acylation product of glycine with caprylic acid chloride. It conforms to the formula: Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , , ,  performance and structural formulation stability.
■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)]
  - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 7215 (辛酰甘氨酸))
  - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment).
  - Official Safety & Historical Use Concentration (Layer 2): Quantum satis (QS) within standard cosmetic safety margins
■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)]
  - [emulsion_cream] Typical range: 0.8 ~ 5.0% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=7, SEPPIC 7)) — Emulsion cream & lotion structural / conditioning agent
■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)]
  - Addition Phase: Water Phase or Cool-down Phase (< 45°C)
  - Optimal pH Range: pH 4.0 ~ 8.0 | Max Process Temp: Max 50°C | Electrolyte Tolerance: MEDIUM
  - Incompatibility / Caution: Verify phase compatibility under extreme pH or high electrolyte loads
  - Synergy Pairings: GLYCERIN, CAPRYLIC/CAPRIC TRIGLYCERIDE, TOCOPHEROL | Reference Trade Names: CAPRYLOYL GLYCINE
■ [6. Peer-Reviewed Literature & Official Compendia Evidence]
  - PMID 33934471 (2021, J Cosmet Dermatol): Capryloyl glycine and soy isoflavonoids in hypertrichosis: An experimental and placebo-controlled clinical study.
  - PMID 30652324 (2019, Contact Dermatitis): Capryloyl glycine: A polyfunctional cosmetic ingredient and potential skin sensitizer.
  - PMID 33347705 (2021, J Cosmet Dermatol): Assessment of the skin efficacy and acceptability of a cosmetic product in the treatment of the forearm hypertrichosis i

## 6. Linked PubMed Literature
- [PMID: 33934471] Capryloyl glycine and soy isoflavonoids in hypertrichosis: An experimental and placebo-controlled clinical study. — *J Cosmet Dermatol* (2021)
- [PMID: 30652324] Capryloyl glycine: A polyfunctional cosmetic ingredient and potential skin sensitizer. — *Contact Dermatitis* (2019)
- [PMID: 33347705] Assessment of the skin efficacy and acceptability of a cosmetic product in the treatment of the forearm hypertrichosis in female patients. — *J Cosmet Dermatol* (2021)
- [PMID: 35460572] Allergic contact dermatitis caused by capryloyl glycine in an atopic dermatitis patient. — *Australas J Dermatol* (2022)