# CAPRYLIC/CAPRIC TRIGLYCERIDE (caprylic-capric-triglyceride) — Global Cosmetic Regulatory & Formulation Monograph - **Canonical URL**: https://www.inciname.com/en/ingredients/caprylic-capric-triglyceride - **Standard INCI**: `CAPRYLIC/CAPRIC TRIGLYCERIDE` - **KR MFDS Standard Name**: `카프릴릭/카프릭트라이글리세라이드` - **CAS No.**: `73398-61-5` - **EC / EINECS No.**: `277-452-2` - **Origin**: `synthetic` - **Functions**: 향료, 용제, 밀폐제 - **Molecular Formula / MW**: `—` (500 g/mol) ## 1. 7-Track Official Regulatory Label Names | Track | Official Label Nomenclature | | :--- | :--- | | KR (MFDS Standard) | 카프릴릭/카프릭트라이글리세라이드 | | KR (Former Names) | 카프릴릭, 카프릭트리글리세라이드 | | EU (CosIng 1223/2009) | CAPRYLIC/CAPRIC TRIGLYCERIDE | | US (PCPC / MoCRA INCI) | CAPRYLIC/CAPRIC TRIGLYCERIDE | | US (FDA OTC Monograph) | — | | CN (NMPA IECIC) | 辛酸/癸酸甘油三酯 | | JP (JCIA / MHLW QD) | トリ（カプリル酸／カプリン酸）グリセリル (QD: トリ２－エチルヘキサン酸グリセリル) | ## 2. Layer 1 — Global 6-Region Statutory Summary - **KR (MFDS)**: `none` - **EU (1223/2009)**: `none` - **US (FDA/MoCRA)**: `none` - **CN (NMPA IECIC)**: `allowed` (Entry: `7206`) - **JP (MHLW)**: `none` - **ASEAN (ACD)**: `none` ## 3. Layer 2 — Toxicological & Historical Safe Use Concentrations - **cn_iecic_max** (leave_on): ≤ 86.4% — NMPA IECIC (2025) Entry 07405 (2025) - **cn_iecic_max** (rinse_off): ≤ 50% — NMPA IECIC (2025) Entry 07405 (2025) ## 4. Layer 3 — Formulation Quartiles & Compatibility - **Optimal pH Window**: 2.5 – 10 - **Max Process Temp**: ≤ 90°C - **Synergy Pairings**: SQUALANE, RETINOL, TOCOPHEROL, CERAMIDE NP, BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE - **Incompatibilities**: Exceptional oxidative stability (iodine value < 1.0); avoid extreme alkaline heating (pH > 10) ## 5. Academic Monograph ■ [1. Chemical Identity & International Labeling Nomenclature] - INCI Name: CAPRYLIC/CAPRIC TRIGLYCERIDE | CAS No.: 73398-61-5 | EC No.: 277-452-2 - Origin: SYNTHETIC | Functions: , , - Physicochemical Profile: Formula | MW 500.0 g/mol | LogP 6.5 | Ionic Nature: non-ionic | PubChem CID 5283469 - Official Regional Label Names: US [CAPRYLIC/CAPRIC TRIGLYCERIDE] · EU [CAPRYLIC/CAPRIC TRIGLYCERIDE] · CN [辛酸/癸酸甘油三酯] · JP [トリ（カプリル酸／カプリン酸）グリセリル] · JP Quasi-Drug [トリ２－エチルヘキサン酸グリセリル] ■ [2. Dermatological Mechanism of Action & Functional Role] - Caprylic/Capric Triglyceride is the mixed triester of glycerin and caprylic and capric acids. Classified under origin 'synthetic', it acts within the cosmetic vehicle or stratum corneum to deliver , , performance and structural formulation stability. ■ [3. Global 6-Jurisdiction Regulatory Status & Safety Limits (Layer 1 & Layer 2)] - Regional Summary: KR: NONE | EU: NONE | US: NONE | CN: ALLOWED | JP: NONE | ASEAN: NONE (CN IECIC (2025) Entry No. 7206 (辛酸/癸酸甘油三酯)) - No specific Annex prohibition or numeric restriction across the 6 major jurisdictions (Permitted under general GMP safety assessment). - Official Safety & Historical Use Concentration (Layer 2): CN_IECIC_2025 (cn_iecic_max, leave_on): Max 86.4% / CN_IECIC_2025 (cn_iecic_max, rinse_off): Max 50.0% ■ [4. Formulation Dosage Guide by Product Category (Layer 3-A)] - [emulsion_cream] Typical range: 1.0 ~ 20.0% (Median 5.0%, Ref: Musim Mas MASESTER E6000 / Evonik TEGOSOFT CT TDS & CIR (n=468)) — Universal medium-chain triglyceride (MCT) emollient & active solvent - [sun_color] Typical range: 2.0 ~ 25.0% (Median 7.0%, Ref: CIR Caprylic/Capric Triglyceride Safety Assessment) — UV filter solvent & pigment wetting carrier oil - [anhydrous_balm] Typical range: 3.0 ~ 51.05% (Median 5.0%, Ref: Global Starter Formulation Library Statistical Distribution (n=15, EVONIK 7 · GRANT 5 · ELEMENTIS 2 · SEPPIC 1)) — Anhydrous balm, oil & stick structural emollient ■ [5. Formulation Engineering, Stability & Incompatibility Matrix (Layer 3-B)] - Addition Phase: Oil Phase - Optimal pH Range: pH 2.5 ~ 10.0 | Max Process Temp: Max 90°C | Electrolyte Tolerance: HIGH - Incompatibility / Caution: Exceptional oxidative stability (iodine value < 1.0); avoid extreme alkaline heating (pH > 10) - Synergy Pairings: SQUALANE, RETINOL, TOCOPHEROL, CERAMIDE NP, BIS-ETHYLHEXYLOXYPHENOL METHOXYPHENYL TRIAZINE | Reference Trade Names: Myritol® 318, TEGOSOFT® CT, MASESTER® E6000 ■ [6. Peer-Reviewed Literature & Official Compendia Evidence] - PMID 34862627 (2022, Contact Dermatitis): Facial allergic contact dermatitis caused by caprylic/capric triglyceride in a cosmetic cream. - PMID 33682031 (2022, Drug Deliv Transl Res): Preformulation and characterization of raloxifene-loaded lipid nanoparticles for transdermal administration. - PMID 38675215 (2024, Pharmaceutics): Microemulsions and Nanoemulsions for Topical Delivery of Tripeptide-3: From Design of Experiment to Anti-Sebum Efficacy ## 6. Linked PubMed Literature - [PMID: 34862627] Facial allergic contact dermatitis caused by caprylic/capric triglyceride in a cosmetic cream. — *Contact Dermatitis* (2022) - [PMID: 33682031] Preformulation and characterization of raloxifene-loaded lipid nanoparticles for transdermal administration. — *Drug Deliv Transl Res* (2022) - [PMID: 38675215] Microemulsions and Nanoemulsions for Topical Delivery of Tripeptide-3: From Design of Experiment to Anti-Sebum Efficacy on Facial Skin. — *Pharmaceutics* (2024) - [PMID: 38083900] Investigation of piroctone olamine delivery to the skin from single, binary and ternary solvent systems — *Int J Cosmet Sci* (2024) - [PMID: 34069268] Dermal Delivery of Niacinamide-In Vivo Studies — *Pharmaceutics* (2021) - [PMID: 33268665] Effect of Lipid and Oil Compositions on Physicochemical Properties and Photoprotection of Octyl Methoxycinnamate-loaded Nanostructured Lipid Carriers (NLC) — *J Oleo Sci* (2020) - [PMID: 32542693] Allergic contact dermatitis caused by caprylic/capric triglyceride from an anti-aging cosmetic cream — *Contact Dermatitis* (2020) - [PMID: 35025234] Penetration of Zinc into Human Skin after Topical Application of Nano Zinc Oxide Used in Commercial Sunscreen Formulations — *ACS Appl Bio Mater* (2020) - [PMID: 32718647] Starch nanocrystals as the particle emulsifier to stabilize caprylic/capric triglycerides-in-water emulsions. — *Carbohydr Polym* (2020) - [PMID: 41033375] The three levels of stabilization in pickering emulsions stabilized by a non-modified bentonite particle: from particle efficiency to emulsion stabilization efficiency — *Int J Pharm* (2025) - [PMID: 39835209] Full-component extract of Crithmum maritimum and its effect on epidermal regeneration — *RSC Adv* (2025) - [PMID: 37109405] Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum — *Life (Basel)* (2023) - [PMID: 33715752] Preparation and Evaluation of Nanostructured Lipid Carrier for Topical Delivery of Velutin: Synthetic Tyrosinase Inhibitor — *J Nanosci Nanotechnol* (2021)